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• W2057221421 endingPage "1798" @default.
• W2057221421 startingPage "1786" @default.
• W2057221421 abstract "Acute treatment with subanesthetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely utilized as a translational model for schizophrenia. However, how acute NMDA receptor blockade impacts on brain functioning at a systems level, to elicit translationally relevant symptomatology and behavioral deficits, has not yet been determined. Here, for the first time, we apply established and recently validated topological measures from network science to brain imaging data gained from ketamine-treated mice to elucidate how acute NMDA receptor blockade impacts on the properties of functional brain networks. We show that the effects of acute ketamine treatment on the global properties of these networks are divergent from those widely reported in schizophrenia. Where acute NMDA receptor blockade promotes hyperconnectivity in functional brain networks, pronounced dysconnectivity is found in schizophrenia. We also show that acute ketamine treatment increases the connectivity and importance of prefrontal and thalamic brain regions in brain networks, a finding also divergent to alterations seen in schizophrenia. In addition, we characterize how ketamine impacts on bipartite functional interactions between neural subsystems. A key feature includes the enhancement of prefrontal cortex (PFC)-neuromodulatory subsystem connectivity in ketamine-treated animals, a finding consistent with the known effects of ketamine on PFC neurotransmitter levels. Overall, our data suggest that, at a systems level, acute ketamine-induced alterations in brain network connectivity do not parallel those seen in chronic schizophrenia. Hence, the mechanisms through which acute ketamine treatment induces translationally relevant symptomatology may differ from those in chronic schizophrenia. Future effort should therefore be dedicated to resolve the conflicting observations between this putative translational model and schizophrenia." @default.
• W2057221421 created "2016-06-24" @default.
• W2057221421 creator A5010638836 @default.
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• W2057221421 creator A5048212348 @default.
• W2057221421 creator A5058486589 @default.
• W2057221421 creator A5075073348 @default.
• W2057221421 date "2014-02-04" @default.
• W2057221421 modified "2023-09-27" @default.
• W2057221421 title "Subanesthetic Ketamine Treatment Promotes Abnormal Interactions between Neural Subsystems and Alters the Properties of Functional Brain Networks" @default.
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• W2057221421 doi "https://doi.org/10.1038/npp.2014.26" @default.
• W2057221421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4023152" @default.
• W2057221421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24492765" @default.
• W2057221421 hasPublicationYear "2014" @default.
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