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• W2057221520 endingPage "1292" @default.
• W2057221520 startingPage "1285" @default.
• W2057221520 abstract "The tumor suppressor C/CAAT enhancer binding protein alpha (C/EBPalpha) is a transcription factor involved in cell cycle control and cellular differentiation. A recent study showed that C/EBPalpha is frequently downregulated in head and neck squamous cell carcinoma (HNSCC) by DNA methylation in an upstream regulatory region. Here, we investigated how DNA methylation in the upstream regulatory region disrupts the transcriptional regulation of C/EBPalpha in HNSCC. The results reveal that aberrant methylation correlates with methyl binding domain protein binding and repressive histone modifications. This methylated region contains previously uninvestigated AP2alpha binding sites. AP2alpha suppresses C/EBPalpha promoter activity and protein expression. Interestingly, silencing AP2alpha by shRNA increases the antiproliferative isoform of C/EBPalpha (p42(C/EBPalpha)). Furthermore, growth analysis revealed that these 2 isoforms yield very different proliferative properties in HNSCC." @default.
• W2057221520 created "2016-06-24" @default.
• W2057221520 creator A5020136143 @default.
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• W2057221520 date "2008-12-16" @default.
• W2057221520 modified "2023-10-01" @default.
• W2057221520 title "Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42^C/EBPα) in head and neck squamous cell carcinoma" @default.
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• W2057221520 doi "https://doi.org/10.1002/ijc.24087" @default.
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