FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057222647> ?p ?o ?g. }

• W2057222647 endingPage "570" @default.
• W2057222647 startingPage "562" @default.
• W2057222647 abstract "Calorie restriction (CR) is one of the most effective nonpharmacological interventions protecting against cardiovascular disease, such as hypertension in the systemic circulation. However, whether CR could attenuate pulmonary arterial hypertension (PAH) is largely unknown. The PAH model was developed by subjecting the rats to a single subcutaneous injection of monocrotaline. CR lowered mean pulmonary arterial pressure (mPAP) and reduced vascular remodeling and right ventricular hypertrophy in PAH rats. Meanwhile, CR attenuated endothelial dysfunction as evidenced by increased relaxation in response to acetylcholine. The beneficial effects of CR were associated with restored sirtuin-1 (SIRT1) expression and endothelial nitric oxide synthase (eNOS) phosphorylation and reduced eNOS acetylation in pulmonary arteries of PAH rats. To further clarify the role of SIRT1 in the protective effects of CR, adenoviral vectors for overexpression of SIRT1 were administered intratracheally at 1 day before monocrotaline injection. Overexpression of SIRT1 exhibited similar beneficial effects on mPAP and endothelial function, and increased eNOS phosphorylation and reduced eNOS acetylation in the absence of CR. Moreover, SIRT1 overexpression attenuated the increase in mPAP in hypoxia-induced PAH animals. Overall, the present data demonstrate that CR may serve as an effective treatment of PAH, and targeting the SIRT1/eNOS pathway may improve treatment of PAH." @default.
• W2057222647 created "2016-06-24" @default.
• W2057222647 creator A5009071140 @default.
• W2057222647 creator A5023846502 @default.
• W2057222647 creator A5024131822 @default.
• W2057222647 creator A5041433151 @default.
• W2057222647 creator A5052803448 @default.
• W2057222647 creator A5075230898 @default.
• W2057222647 creator A5078343111 @default.
• W2057222647 creator A5078843118 @default.
• W2057222647 creator A5084964383 @default.
• W2057222647 creator A5088170766 @default.
• W2057222647 date "2015-06-01" @default.
• W2057222647 modified "2023-09-28" @default.
• W2057222647 title "Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats" @default.
• W2057222647 cites W1523806395 @default.
• W2057222647 cites W1769035943 @default.
• W2057222647 cites W1901983160 @default.
• W2057222647 cites W1909145326 @default.
• W2057222647 cites W1959822942 @default.
• W2057222647 cites W1965055751 @default.
• W2057222647 cites W1974617256 @default.
• W2057222647 cites W1976735273 @default.
• W2057222647 cites W1994408786 @default.
• W2057222647 cites W1995188356 @default.
• W2057222647 cites W2001327293 @default.
• W2057222647 cites W2001738812 @default.
• W2057222647 cites W2009559340 @default.
• W2057222647 cites W2018064469 @default.
• W2057222647 cites W2018721873 @default.
• W2057222647 cites W2021000047 @default.
• W2057222647 cites W2025717255 @default.
• W2057222647 cites W2052448737 @default.
• W2057222647 cites W2052749010 @default.
• W2057222647 cites W2054025912 @default.
• W2057222647 cites W2059341870 @default.
• W2057222647 cites W2061675399 @default.
• W2057222647 cites W2073283943 @default.
• W2057222647 cites W2079785506 @default.
• W2057222647 cites W2083860193 @default.
• W2057222647 cites W2084285054 @default.
• W2057222647 cites W2091060831 @default.
• W2057222647 cites W2099470576 @default.
• W2057222647 cites W2117082349 @default.
• W2057222647 cites W2121141378 @default.
• W2057222647 cites W2121808478 @default.
• W2057222647 cites W2128737073 @default.
• W2057222647 cites W2141537184 @default.
• W2057222647 cites W2143199174 @default.
• W2057222647 cites W2144597344 @default.
• W2057222647 cites W2146966841 @default.
• W2057222647 cites W2151938215 @default.
• W2057222647 cites W2157004398 @default.
• W2057222647 cites W2166629626 @default.
• W2057222647 cites W2169220357 @default.
• W2057222647 cites W2170194742 @default.
• W2057222647 cites W2170478368 @default.
• W2057222647 cites W2171035344 @default.
• W2057222647 cites W2172186904 @default.
• W2057222647 cites W2325655716 @default.
• W2057222647 cites W2767379324 @default.
• W2057222647 cites W4243992863 @default.
• W2057222647 doi "https://doi.org/10.1097/fjc.0000000000000224" @default.
• W2057222647 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4461391" @default.
• W2057222647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25636073" @default.
• W2057222647 hasPublicationYear "2015" @default.
• W2057222647 type Work @default.
• W2057222647 sameAs 2057222647 @default.
• W2057222647 citedByCount "16" @default.
• W2057222647 countsByYear W20572226472015 @default.
• W2057222647 countsByYear W20572226472016 @default.
• W2057222647 countsByYear W20572226472017 @default.
• W2057222647 countsByYear W20572226472018 @default.
• W2057222647 countsByYear W20572226472019 @default.
• W2057222647 countsByYear W20572226472020 @default.
• W2057222647 countsByYear W20572226472021 @default.
• W2057222647 countsByYear W20572226472022 @default.
• W2057222647 crossrefType "journal-article" @default.
• W2057222647 hasAuthorship W2057222647A5009071140 @default.
• W2057222647 hasAuthorship W2057222647A5023846502 @default.
• W2057222647 hasAuthorship W2057222647A5024131822 @default.
• W2057222647 hasAuthorship W2057222647A5041433151 @default.
• W2057222647 hasAuthorship W2057222647A5052803448 @default.
• W2057222647 hasAuthorship W2057222647A5075230898 @default.
• W2057222647 hasAuthorship W2057222647A5078343111 @default.
• W2057222647 hasAuthorship W2057222647A5078843118 @default.
• W2057222647 hasAuthorship W2057222647A5084964383 @default.
• W2057222647 hasAuthorship W2057222647A5088170766 @default.
• W2057222647 hasBestOaLocation W20572226472 @default.
• W2057222647 hasConcept C104317684 @default.
• W2057222647 hasConcept C126322002 @default.
• W2057222647 hasConcept C127561419 @default.
• W2057222647 hasConcept C134018914 @default.
• W2057222647 hasConcept C178790620 @default.
• W2057222647 hasConcept C185592680 @default.
• W2057222647 hasConcept C2776536020 @default.
• W2057222647 hasConcept C2777622882 @default.
• W2057222647 hasConcept C2778326061 @default.

• next