FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057224144> ?p ?o ?g. }

• W2057224144 endingPage "3652" @default.
• W2057224144 startingPage "3644" @default.
• W2057224144 abstract "Treatment for acromegaly patients with long-acting somatotropin release-inhibiting factor (LA-SRIF) often does not result in complete normalization of IGF-1. Addition of pegvisomant (PEGV), a GH receptor antagonist, could improve this; however, the literature has not described long-term follow-up. To assess long-term efficacy and safety of this combined treatment in the largest current single-center cohort of patients, from 2004–2013. Acromegaly patients were treated for at least 6 months with a high-dose LA-SRIF. To patients with persistently elevated IGF-1 levels (>1.2 × upper limit of normal) or poor quality of life, PEGV was added as one weekly injection. The patients (n = 141) were treated with PEGV and LA-SRIFs for a median period of 4.9 years (range, 0.5–9.2). Efficacy, defined as the lowest measured IGF-1 level during treatment, was 97.0%. The median PEGV dose to achieve this efficacy was 80 mg weekly (interquartile range, 60–120 mg). Combination treatment-related adverse events were recorded in 26 subjects (18.4%). Pituitary tumor size increase was observed in one patient. Injection-site reactions were observed in four subjects. In 19 patients (13.5%), transiently elevated liver transaminases of more than three times the upper limit of normal were observed, of which 83% occurred within the first year of combination treatment. Eight patients died, at a mean age of 71 years; none of them were considered treatment-related. The combination treatment with LA-SRIFs and PEGV was effective in 97% of the patients, it appears to be a safe medical treatment and it reduces the required dose of PEGV." @default.
• W2057224144 created "2016-06-24" @default.
• W2057224144 creator A5006066076 @default.
• W2057224144 creator A5023048333 @default.
• W2057224144 creator A5024586979 @default.
• W2057224144 creator A5026436166 @default.
• W2057224144 creator A5034448007 @default.
• W2057224144 creator A5040710891 @default.
• W2057224144 creator A5049815219 @default.
• W2057224144 creator A5059140376 @default.
• W2057224144 creator A5071394452 @default.
• W2057224144 creator A5085146317 @default.
• W2057224144 creator A5090850055 @default.
• W2057224144 date "2014-10-01" @default.
• W2057224144 modified "2023-10-02" @default.
• W2057224144 title "Long-Term Efficacy and Safety of Pegvisomant in Combination With Long-Acting Somatostatin Analogs in Acromegaly" @default.
• W2057224144 cites W123434114 @default.
• W2057224144 cites W1958294916 @default.
• W2057224144 cites W1967240999 @default.
• W2057224144 cites W1969253479 @default.
• W2057224144 cites W1969427273 @default.
• W2057224144 cites W1978089434 @default.
• W2057224144 cites W1988158211 @default.
• W2057224144 cites W1993154503 @default.
• W2057224144 cites W1994013062 @default.
• W2057224144 cites W2027626160 @default.
• W2057224144 cites W2033517727 @default.
• W2057224144 cites W2062054706 @default.
• W2057224144 cites W2068704610 @default.
• W2057224144 cites W2086782730 @default.
• W2057224144 cites W2097793173 @default.
• W2057224144 cites W2099181842 @default.
• W2057224144 cites W2107724413 @default.
• W2057224144 cites W2108583295 @default.
• W2057224144 cites W2111972036 @default.
• W2057224144 cites W2121326610 @default.
• W2057224144 cites W2131231109 @default.
• W2057224144 cites W2136266310 @default.
• W2057224144 cites W2138068788 @default.
• W2057224144 cites W2138736796 @default.
• W2057224144 cites W2139926910 @default.
• W2057224144 cites W2143791513 @default.
• W2057224144 cites W2147795491 @default.
• W2057224144 cites W2153200944 @default.
• W2057224144 cites W2169376102 @default.
• W2057224144 cites W2322536880 @default.
• W2057224144 cites W2339145711 @default.
• W2057224144 doi "https://doi.org/10.1210/jc.2014-2032" @default.
• W2057224144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24937542" @default.
• W2057224144 hasPublicationYear "2014" @default.
• W2057224144 type Work @default.
• W2057224144 sameAs 2057224144 @default.
• W2057224144 citedByCount "98" @default.
• W2057224144 countsByYear W20572241442015 @default.
• W2057224144 countsByYear W20572241442016 @default.
• W2057224144 countsByYear W20572241442017 @default.
• W2057224144 countsByYear W20572241442018 @default.
• W2057224144 countsByYear W20572241442019 @default.
• W2057224144 countsByYear W20572241442020 @default.
• W2057224144 countsByYear W20572241442021 @default.
• W2057224144 countsByYear W20572241442022 @default.
• W2057224144 countsByYear W20572241442023 @default.
• W2057224144 crossrefType "journal-article" @default.
• W2057224144 hasAuthorship W2057224144A5006066076 @default.
• W2057224144 hasAuthorship W2057224144A5023048333 @default.
• W2057224144 hasAuthorship W2057224144A5024586979 @default.
• W2057224144 hasAuthorship W2057224144A5026436166 @default.
• W2057224144 hasAuthorship W2057224144A5034448007 @default.
• W2057224144 hasAuthorship W2057224144A5040710891 @default.
• W2057224144 hasAuthorship W2057224144A5049815219 @default.
• W2057224144 hasAuthorship W2057224144A5059140376 @default.
• W2057224144 hasAuthorship W2057224144A5071394452 @default.
• W2057224144 hasAuthorship W2057224144A5085146317 @default.
• W2057224144 hasAuthorship W2057224144A5090850055 @default.
• W2057224144 hasConcept C119060515 @default.
• W2057224144 hasConcept C126322002 @default.
• W2057224144 hasConcept C134018914 @default.
• W2057224144 hasConcept C197934379 @default.
• W2057224144 hasConcept C2776297358 @default.
• W2057224144 hasConcept C2777433750 @default.
• W2057224144 hasConcept C2778375690 @default.
• W2057224144 hasConcept C2778886798 @default.
• W2057224144 hasConcept C2984496839 @default.
• W2057224144 hasConcept C71315377 @default.
• W2057224144 hasConcept C71924100 @default.
• W2057224144 hasConcept C72563966 @default.
• W2057224144 hasConcept C90924648 @default.
• W2057224144 hasConceptScore W2057224144C119060515 @default.
• W2057224144 hasConceptScore W2057224144C126322002 @default.
• W2057224144 hasConceptScore W2057224144C134018914 @default.
• W2057224144 hasConceptScore W2057224144C197934379 @default.
• W2057224144 hasConceptScore W2057224144C2776297358 @default.
• W2057224144 hasConceptScore W2057224144C2777433750 @default.
• W2057224144 hasConceptScore W2057224144C2778375690 @default.
• W2057224144 hasConceptScore W2057224144C2778886798 @default.
• W2057224144 hasConceptScore W2057224144C2984496839 @default.
• W2057224144 hasConceptScore W2057224144C71315377 @default.
• W2057224144 hasConceptScore W2057224144C71924100 @default.

• next