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• W2057226112 endingPage "3682" @default.
• W2057226112 startingPage "3677" @default.
• W2057226112 abstract "A novel class of CMV protease inhibitors based on a benzothiopyran-S,S-dioxide nucleus has been discovered. Enzyme kinetic data supports a reversible mode of inhibition for a representative member of this class, 2-(3-pyridyl-N-oxide)benzothiopyran-4-one-S,S-dioxide, 1. Experiments in the presence and absence of the disulfide reducing agent DTT suggest that the inhibition by 1 is not due to oxidative inactivation of the enzyme. Also presented are results of some SAR studies of the benzothiopyranone ring system." @default.
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• W2057226112 date "1998-12-01" @default.
• W2057226112 modified "2023-09-23" @default.
• W2057226112 title "Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease" @default.
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• W2057226112 doi "https://doi.org/10.1016/s0960-894x(98)00666-0" @default.
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