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- W2057226795 endingPage "599" @default.
- W2057226795 startingPage "577" @default.
- W2057226795 abstract "The past decade has seen substantial developments in our understanding of the physiology, pathology, and pharmacology of heme oxygenases (HO), to the point that investigators in the field are beginning to contemplate therapies based on administration of HO agonists or HO inhibitors. A significant amount of our current knowledge is based on the judicious application of metalloporphyrin inhibitors of HO, despite their limitations of selectivity. Recently, imidazole-based compounds have been identified as potent and more selective HO inhibitors. This ‘next generation’ of HO inhibitors offers a number of desirable characteristics, including isozyme selectivity, negligible effects on HO protein expression, and physicochemical properties favourable for in vivo distribution. Some of the applications of HO inhibitors that have been suggested are treatment of hyperbilirubinemia, neurodegenerative disorders, certain types of cancer, and bacterial and fungal infections. In this review, we address various approaches to altering HO activity with a focus on the potential applications of second-generation inhibitors of HO." @default.
- W2057226795 created "2016-06-24" @default.
- W2057226795 creator A5080203290 @default.
- W2057226795 creator A5085185958 @default.
- W2057226795 creator A5089555217 @default.
- W2057226795 date "2008-09-01" @default.
- W2057226795 modified "2023-10-17" @default.
- W2057226795 title "Inhibitors of the heme oxygenase – carbon monoxide system: on the doorstep of the clinic?" @default.
- W2057226795 cites W101745106 @default.
- W2057226795 cites W1482578950 @default.
- W2057226795 cites W1483926031 @default.
- W2057226795 cites W1508318473 @default.
- W2057226795 cites W1512339474 @default.
- W2057226795 cites W1517026994 @default.
- W2057226795 cites W1529948332 @default.
- W2057226795 cites W1533177616 @default.
- W2057226795 cites W1536484729 @default.
- W2057226795 cites W1559821198 @default.
- W2057226795 cites W1566780076 @default.
- W2057226795 cites W1572334445 @default.
- W2057226795 cites W1586487499 @default.
- W2057226795 cites W1591240009 @default.
- W2057226795 cites W1592939002 @default.
- W2057226795 cites W1596892984 @default.
- W2057226795 cites W1600338077 @default.
- W2057226795 cites W1600690434 @default.
- W2057226795 cites W1607642615 @default.
- W2057226795 cites W1611419331 @default.
- W2057226795 cites W1623210390 @default.
- W2057226795 cites W1655162787 @default.
- W2057226795 cites W176337846 @default.
- W2057226795 cites W1807201726 @default.
- W2057226795 cites W1819471220 @default.
- W2057226795 cites W182074725 @default.
- W2057226795 cites W1829187584 @default.
- W2057226795 cites W1865602869 @default.
- W2057226795 cites W1869396256 @default.
- W2057226795 cites W193854047 @default.
- W2057226795 cites W1939358434 @default.
- W2057226795 cites W1963723754 @default.
- W2057226795 cites W1964320031 @default.
- W2057226795 cites W1965187409 @default.
- W2057226795 cites W1965787226 @default.
- W2057226795 cites W1966443605 @default.
- W2057226795 cites W1966582616 @default.
- W2057226795 cites W1966884476 @default.
- W2057226795 cites W1969211911 @default.
- W2057226795 cites W1970787316 @default.
- W2057226795 cites W1972252836 @default.
- W2057226795 cites W1972526878 @default.
- W2057226795 cites W1973185752 @default.
- W2057226795 cites W1973272666 @default.
- W2057226795 cites W1973466019 @default.
- W2057226795 cites W1974037978 @default.
- W2057226795 cites W1974297472 @default.
- W2057226795 cites W1975554304 @default.
- W2057226795 cites W1976866228 @default.
- W2057226795 cites W1976916629 @default.
- W2057226795 cites W1977427732 @default.
- W2057226795 cites W1978444132 @default.
- W2057226795 cites W1978765308 @default.
- W2057226795 cites W1979190686 @default.
- W2057226795 cites W1979672764 @default.
- W2057226795 cites W1980090453 @default.
- W2057226795 cites W1980351331 @default.
- W2057226795 cites W1980987756 @default.
- W2057226795 cites W1981628197 @default.
- W2057226795 cites W1981860537 @default.
- W2057226795 cites W1982669384 @default.
- W2057226795 cites W1983339726 @default.
- W2057226795 cites W1983526553 @default.
- W2057226795 cites W1983895879 @default.
- W2057226795 cites W1984660216 @default.
- W2057226795 cites W1985096908 @default.
- W2057226795 cites W1986251869 @default.
- W2057226795 cites W1986829301 @default.
- W2057226795 cites W1987718013 @default.
- W2057226795 cites W1987777210 @default.
- W2057226795 cites W1987991824 @default.
- W2057226795 cites W1989327883 @default.
- W2057226795 cites W1989791059 @default.
- W2057226795 cites W1990314210 @default.
- W2057226795 cites W1990465549 @default.
- W2057226795 cites W1990618897 @default.
- W2057226795 cites W1991303210 @default.
- W2057226795 cites W1993157288 @default.
- W2057226795 cites W1993596487 @default.
- W2057226795 cites W1994197049 @default.
- W2057226795 cites W1995633773 @default.
- W2057226795 cites W1995726976 @default.
- W2057226795 cites W1995756309 @default.
- W2057226795 cites W1996181493 @default.
- W2057226795 cites W1997507706 @default.
- W2057226795 cites W1998262397 @default.
- W2057226795 cites W2000312541 @default.
- W2057226795 cites W2000370758 @default.
- W2057226795 cites W2000495014 @default.
- W2057226795 cites W2000933654 @default.