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- W2057227460 abstract "K[Pt(NH3)Cl3], a valuable precursor for the preparation of platinum complexes with cytostatic activity, e.g. satraplatin, picoplatin, LA-12 and cycloplatam, is currently prepared from cis-[Pt(NH3)2Cl2] or K2[PtCl4] and these are the usual impurities in the final product. A simple, selective and sensitive HPLC-UV analytical method for the determination of the purity of K[Pt(NH3)Cl3] and the quantification of the impurities has been developed and validated. The platinum complexes present in the final product were separated on a strong base ion exchange column by the gradient elution with detection at 213 nm. Intra-assay precisions for the platinum complexes respective to their ions ([PtCl4]2−, [Pt(NH3)Cl3]− and cis-[Pt(NH3)2Cl2]) were between 0.1 and 2.0% (relative standard deviation); intermediate precisions were between 1.4 and 2.0% and accuracies were between 98.6 and 101.4%. Limits of detection of [PtCl4]2−, [Pt(NH3)Cl3]− and cis-[Pt(NH3)2Cl2] were 6 µg · ml−1, 13 mg · ml−1 and 5 µg · ml−1 respectively, limits of quantification of [PtCl4]2−, [Pt(NH3)Cl3]− and cis-[Pt(NH3)2Cl2] were 51 µg · ml−1, 55 mg · ml−1 and 20 µg · ml−1 respectively." @default.
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- W2057227460 date "2011-08-01" @default.
- W2057227460 modified "2023-09-23" @default.
- W2057227460 title "HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity" @default.
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- W2057227460 doi "https://doi.org/10.1080/00032719.2010.546027" @default.
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