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- W2057241177 abstract "The relative sensitivity of rat tissue catalase to inhibition by intraperitoneally administered cyanamide was liver > kidney > heart > brain, whereas the activity of the erythrocyte enzyme was affected minimally. The measured ED50 values for cyanamide in these tissues were 31, 44, 107 and 680 μmoles/kg body weight for liver, kidney, heart and brain respectively. On a molar basis, cyanamide was approximately twenty times more potent than 3-amino-1,2,4-triazole (3-AT) in inhibiting hepatic catalase in vivo in the rat. Like 3-AT, cyanamide inhibited erythrocyte catalase activity in vitro in the presence of hydrogen peroxide. The apparent similarities between the inhibition of hepatic catalase by cyanamide and 3-AT in vivo suggest that cyanamide belongs to the family of 3-AT-like catalase inhibitors." @default.
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- W2057241177 date "1986-07-01" @default.
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- W2057241177 title "Differential inhibition of rat tissue catalase by cyanamide" @default.
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- W2057241177 doi "https://doi.org/10.1016/0006-2952(86)90574-5" @default.
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