FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057242020> ?p ?o ?g. }

• W2057242020 endingPage "323" @default.
• W2057242020 startingPage "317" @default.
• W2057242020 abstract "BackgroundA discrepancy between characteristics of patients treated with carotid angioplasty and stent placement (CAS) within and outside clinical trials, particularly characteristics with direct impact on clinical outcome, may limit generalization of clinical trial results. The objective of this study was to identify differences in demographic and clinical characteristics and outcomes related to CAS in patients treated within clinical trials and those treated outside clinical trials in a large national cohort.MethodsWe determined the frequency of CAS performed within and outside clinical trials and associated in-hospital outcomes using data from the Nationwide Inpatient Survey data files from 2005 to 2009. All the in-hospital outcomes were analyzed after adjusting for potential confounders using multivariate analysis.ResultsOf the 81,638 patients who underwent CAS, 16,078 (19.6%) underwent the procedure as part of a clinical trial. The mean age of the patients was significantly lower in patients treated with CAS as part of a clinical trial than those treated with CAS outside a clinical trial. The proportion of women and nonwhites was lower among patients treated with CAS as part of a clinical trial. The in-hospital mortality was two-fold higher among patients treated with CAS outside clinical trials (1.12% vs 0.53%; P = .0005). The rate of composite endpoint of stroke, cardiac events, and death was significantly higher among patients treated with CAS outside clinical trials (P = .02). After adjusting for age, gender, presence of renal failure, and hospital bed size, CAS performed as part of a clinical trial was associated with lower rates of in-hospital mortality (odds ratio, 0.467; 95% confidence interval, 0.290-0.751; P = .0017) and composite endpoint of stroke, cardiac events, and death (odds ratio, 0.752; 95% confidence interval, 0.594-0.952; P = .0180).ConclusionsOur results suggest that CAS procedures performed as part of clinical trials was associated with lower rates of in-hospital mortality and composite endpoint of stroke, cardiac events, and death in United States. These findings highlight the need for strategies that ensure appropriate adoption of CAS to ensure that the benefits observed in clinical trials can be replicated in general practice. A discrepancy between characteristics of patients treated with carotid angioplasty and stent placement (CAS) within and outside clinical trials, particularly characteristics with direct impact on clinical outcome, may limit generalization of clinical trial results. The objective of this study was to identify differences in demographic and clinical characteristics and outcomes related to CAS in patients treated within clinical trials and those treated outside clinical trials in a large national cohort. We determined the frequency of CAS performed within and outside clinical trials and associated in-hospital outcomes using data from the Nationwide Inpatient Survey data files from 2005 to 2009. All the in-hospital outcomes were analyzed after adjusting for potential confounders using multivariate analysis. Of the 81,638 patients who underwent CAS, 16,078 (19.6%) underwent the procedure as part of a clinical trial. The mean age of the patients was significantly lower in patients treated with CAS as part of a clinical trial than those treated with CAS outside a clinical trial. The proportion of women and nonwhites was lower among patients treated with CAS as part of a clinical trial. The in-hospital mortality was two-fold higher among patients treated with CAS outside clinical trials (1.12% vs 0.53%; P = .0005). The rate of composite endpoint of stroke, cardiac events, and death was significantly higher among patients treated with CAS outside clinical trials (P = .02). After adjusting for age, gender, presence of renal failure, and hospital bed size, CAS performed as part of a clinical trial was associated with lower rates of in-hospital mortality (odds ratio, 0.467; 95% confidence interval, 0.290-0.751; P = .0017) and composite endpoint of stroke, cardiac events, and death (odds ratio, 0.752; 95% confidence interval, 0.594-0.952; P = .0180). Our results suggest that CAS procedures performed as part of clinical trials was associated with lower rates of in-hospital mortality and composite endpoint of stroke, cardiac events, and death in United States. These findings highlight the need for strategies that ensure appropriate adoption of CAS to ensure that the benefits observed in clinical trials can be replicated in general practice." @default.
• W2057242020 created "2016-06-24" @default.
• W2057242020 creator A5001606804 @default.
• W2057242020 creator A5017649380 @default.
• W2057242020 creator A5036895407 @default.
• W2057242020 creator A5041092012 @default.
• W2057242020 creator A5041979387 @default.
• W2057242020 creator A5054796414 @default.
• W2057242020 creator A5066933773 @default.
• W2057242020 date "2012-08-01" @default.
• W2057242020 modified "2023-10-18" @default.
• W2057242020 title "A comparison of outcomes associated with carotid artery stent placement performed within and outside clinical trials in the United States" @default.
• W2057242020 cites W127266610 @default.
• W2057242020 cites W1838439429 @default.
• W2057242020 cites W1965981448 @default.
• W2057242020 cites W1973730575 @default.
• W2057242020 cites W1977340056 @default.
• W2057242020 cites W1988967245 @default.
• W2057242020 cites W1997767940 @default.
• W2057242020 cites W2011877903 @default.
• W2057242020 cites W2026670870 @default.
• W2057242020 cites W2038169486 @default.
• W2057242020 cites W2047100391 @default.
• W2057242020 cites W2065740147 @default.
• W2057242020 cites W2069243216 @default.
• W2057242020 cites W2077861519 @default.
• W2057242020 cites W2079003983 @default.
• W2057242020 cites W2100194095 @default.
• W2057242020 cites W2101344162 @default.
• W2057242020 cites W2103547980 @default.
• W2057242020 cites W2107655025 @default.
• W2057242020 cites W2107752063 @default.
• W2057242020 cites W2108438257 @default.
• W2057242020 cites W2123898975 @default.
• W2057242020 cites W2134565153 @default.
• W2057242020 cites W2146045997 @default.
• W2057242020 cites W2150415743 @default.
• W2057242020 cites W2151117182 @default.
• W2057242020 cites W2152221888 @default.
• W2057242020 cites W2154316676 @default.
• W2057242020 cites W2469958479 @default.
• W2057242020 cites W3205926832 @default.
• W2057242020 doi "https://doi.org/10.1016/j.jvs.2012.01.030" @default.
• W2057242020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22560333" @default.
• W2057242020 hasPublicationYear "2012" @default.
• W2057242020 type Work @default.
• W2057242020 sameAs 2057242020 @default.
• W2057242020 citedByCount "19" @default.
• W2057242020 countsByYear W20572420202013 @default.
• W2057242020 countsByYear W20572420202014 @default.
• W2057242020 countsByYear W20572420202015 @default.
• W2057242020 countsByYear W20572420202016 @default.
• W2057242020 countsByYear W20572420202017 @default.
• W2057242020 countsByYear W20572420202019 @default.
• W2057242020 countsByYear W20572420202022 @default.
• W2057242020 countsByYear W20572420202023 @default.
• W2057242020 crossrefType "journal-article" @default.
• W2057242020 hasAuthorship W2057242020A5001606804 @default.
• W2057242020 hasAuthorship W2057242020A5017649380 @default.
• W2057242020 hasAuthorship W2057242020A5036895407 @default.
• W2057242020 hasAuthorship W2057242020A5041092012 @default.
• W2057242020 hasAuthorship W2057242020A5041979387 @default.
• W2057242020 hasAuthorship W2057242020A5054796414 @default.
• W2057242020 hasAuthorship W2057242020A5066933773 @default.
• W2057242020 hasBestOaLocation W20572420201 @default.
• W2057242020 hasConcept C126322002 @default.
• W2057242020 hasConcept C127413603 @default.
• W2057242020 hasConcept C141071460 @default.
• W2057242020 hasConcept C2780645631 @default.
• W2057242020 hasConcept C535046627 @default.
• W2057242020 hasConcept C71924100 @default.
• W2057242020 hasConcept C72563966 @default.
• W2057242020 hasConcept C77350462 @default.
• W2057242020 hasConcept C78519656 @default.
• W2057242020 hasConceptScore W2057242020C126322002 @default.
• W2057242020 hasConceptScore W2057242020C127413603 @default.
• W2057242020 hasConceptScore W2057242020C141071460 @default.
• W2057242020 hasConceptScore W2057242020C2780645631 @default.
• W2057242020 hasConceptScore W2057242020C535046627 @default.
• W2057242020 hasConceptScore W2057242020C71924100 @default.
• W2057242020 hasConceptScore W2057242020C72563966 @default.
• W2057242020 hasConceptScore W2057242020C77350462 @default.
• W2057242020 hasConceptScore W2057242020C78519656 @default.
• W2057242020 hasIssue "2" @default.
• W2057242020 hasLocation W20572420201 @default.
• W2057242020 hasLocation W20572420202 @default.
• W2057242020 hasOpenAccess W2057242020 @default.
• W2057242020 hasPrimaryLocation W20572420201 @default.
• W2057242020 hasRelatedWork W1992228662 @default.
• W2057242020 hasRelatedWork W2188664023 @default.
• W2057242020 hasRelatedWork W2481749367 @default.
• W2057242020 hasRelatedWork W2585911331 @default.
• W2057242020 hasRelatedWork W2793477322 @default.
• W2057242020 hasRelatedWork W2994176440 @default.
• W2057242020 hasRelatedWork W4236720793 @default.
• W2057242020 hasRelatedWork W4237074691 @default.
• W2057242020 hasRelatedWork W4246786946 @default.
• W2057242020 hasRelatedWork W830718730 @default.

• next