FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057246768> ?p ?o ?g. }

• W2057246768 endingPage "551" @default.
• W2057246768 startingPage "533" @default.
• W2057246768 abstract "Macrophages from animals prone to autoimmune (type 1) diabetes differ from those of diabetes-resistant animals in processing and clearing apoptotic cells. Using in vitro time-course assays of the number of engulfed apoptotic cells observed within macrophages, we quantified these differences in non-obese diabetic (NOD) versus Balb/c mice. Simple models lead to several elementary parameter estimation techniques. We used these to compute approximate rates of macrophage engulfment and digestion of apoptotic cells from basic features of the data (such as initial rise-times, phagocytic index and percent phagocytosis). Combining these estimates with full fitting of a sequence of model variants to the data, we find that macrophages from normal (Balb/c) mice engulf apoptotic cells up to four times faster than macrophages from the diabetes-prone (NOD) mice. Further, Balb/c macrophages appear to undergo an activation step before achieving their high engulfment rate. In NOD macrophages, we did not see evidence for this activation step. Rates of digestion of engulfed apoptotic cells by macrophages are similar in both types. Since macrophage clearance is an important mechanism of disposal of self-antigen, these macrophage defects could potentially be a factor in predisposition to type 1 diabetes." @default.
• W2057246768 created "2016-06-24" @default.
• W2057246768 creator A5000637278 @default.
• W2057246768 creator A5001326874 @default.
• W2057246768 creator A5010215397 @default.
• W2057246768 creator A5048414290 @default.
• W2057246768 creator A5065805531 @default.
• W2057246768 creator A5073366823 @default.
• W2057246768 date "2005-04-01" @default.
• W2057246768 modified "2023-10-18" @default.
• W2057246768 title "Quantifying macrophage defects in type 1 diabetes" @default.
• W2057246768 cites W1598813349 @default.
• W2057246768 cites W1895115148 @default.
• W2057246768 cites W1964287788 @default.
• W2057246768 cites W1968371014 @default.
• W2057246768 cites W1982258483 @default.
• W2057246768 cites W1990494705 @default.
• W2057246768 cites W1997636031 @default.
• W2057246768 cites W2001104014 @default.
• W2057246768 cites W2063797436 @default.
• W2057246768 cites W2069819213 @default.
• W2057246768 cites W2101331467 @default.
• W2057246768 cites W2115677315 @default.
• W2057246768 cites W2126643398 @default.
• W2057246768 cites W2138075076 @default.
• W2057246768 cites W2146259054 @default.
• W2057246768 cites W2150642049 @default.
• W2057246768 cites W2164081168 @default.
• W2057246768 cites W216894380 @default.
• W2057246768 cites W2256578114 @default.
• W2057246768 doi "https://doi.org/10.1016/j.jtbi.2004.10.030" @default.
• W2057246768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15748914" @default.
• W2057246768 hasPublicationYear "2005" @default.
• W2057246768 type Work @default.
• W2057246768 sameAs 2057246768 @default.
• W2057246768 citedByCount "55" @default.
• W2057246768 countsByYear W20572467682012 @default.
• W2057246768 countsByYear W20572467682013 @default.
• W2057246768 countsByYear W20572467682014 @default.
• W2057246768 countsByYear W20572467682015 @default.
• W2057246768 countsByYear W20572467682016 @default.
• W2057246768 countsByYear W20572467682017 @default.
• W2057246768 countsByYear W20572467682018 @default.
• W2057246768 countsByYear W20572467682019 @default.
• W2057246768 countsByYear W20572467682020 @default.
• W2057246768 countsByYear W20572467682022 @default.
• W2057246768 countsByYear W20572467682023 @default.
• W2057246768 crossrefType "journal-article" @default.
• W2057246768 hasAuthorship W2057246768A5000637278 @default.
• W2057246768 hasAuthorship W2057246768A5001326874 @default.
• W2057246768 hasAuthorship W2057246768A5010215397 @default.
• W2057246768 hasAuthorship W2057246768A5048414290 @default.
• W2057246768 hasAuthorship W2057246768A5065805531 @default.
• W2057246768 hasAuthorship W2057246768A5073366823 @default.
• W2057246768 hasConcept C134018914 @default.
• W2057246768 hasConcept C160448771 @default.
• W2057246768 hasConcept C190283241 @default.
• W2057246768 hasConcept C202751555 @default.
• W2057246768 hasConcept C203014093 @default.
• W2057246768 hasConcept C2778013207 @default.
• W2057246768 hasConcept C2779244956 @default.
• W2057246768 hasConcept C2781232474 @default.
• W2057246768 hasConcept C55493867 @default.
• W2057246768 hasConcept C555293320 @default.
• W2057246768 hasConcept C55851684 @default.
• W2057246768 hasConcept C86803240 @default.
• W2057246768 hasConcept C8891405 @default.
• W2057246768 hasConcept C95444343 @default.
• W2057246768 hasConceptScore W2057246768C134018914 @default.
• W2057246768 hasConceptScore W2057246768C160448771 @default.
• W2057246768 hasConceptScore W2057246768C190283241 @default.
• W2057246768 hasConceptScore W2057246768C202751555 @default.
• W2057246768 hasConceptScore W2057246768C203014093 @default.
• W2057246768 hasConceptScore W2057246768C2778013207 @default.
• W2057246768 hasConceptScore W2057246768C2779244956 @default.
• W2057246768 hasConceptScore W2057246768C2781232474 @default.
• W2057246768 hasConceptScore W2057246768C55493867 @default.
• W2057246768 hasConceptScore W2057246768C555293320 @default.
• W2057246768 hasConceptScore W2057246768C55851684 @default.
• W2057246768 hasConceptScore W2057246768C86803240 @default.
• W2057246768 hasConceptScore W2057246768C8891405 @default.
• W2057246768 hasConceptScore W2057246768C95444343 @default.
• W2057246768 hasIssue "4" @default.
• W2057246768 hasLocation W20572467681 @default.
• W2057246768 hasLocation W20572467682 @default.
• W2057246768 hasOpenAccess W2057246768 @default.
• W2057246768 hasPrimaryLocation W20572467681 @default.
• W2057246768 hasRelatedWork W11189207 @default.
• W2057246768 hasRelatedWork W1763016828 @default.
• W2057246768 hasRelatedWork W2056965678 @default.
• W2057246768 hasRelatedWork W2076513055 @default.
• W2057246768 hasRelatedWork W2076559131 @default.
• W2057246768 hasRelatedWork W2100599721 @default.
• W2057246768 hasRelatedWork W2126232873 @default.
• W2057246768 hasRelatedWork W2410457253 @default.
• W2057246768 hasRelatedWork W2434178130 @default.
• W2057246768 hasRelatedWork W2120091065 @default.
• W2057246768 hasVolume "233" @default.

• next