Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057254893> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2057254893 endingPage "174" @default.
- W2057254893 startingPage "171" @default.
- W2057254893 abstract "Diphenhydramine is one of the first effective antihistamine agents to have been discovered. The compound is also used for its sedative and antiemetic effects. The first case involving repetitive sedation linked to the use of diphenhydramine as a drug-facilitated crime and subsequent impairment of a 9-year-old female victim is reported. Due to the long delay between the alleged crime and clinical examination, collection of blood or urine was of little value. Hence, the laboratory developed an original approach based on hair testing by LC-MS/MS. A single strand of hair from the victim was sampled about 7 weeks after the last suspected administration and was cut into small segments. After cutting into small pieces, about 20 mg of hair per segment was incubated overnight in a phosphate buffer (pH 8.4). The aqueous phase was extracted with 5 ml of a mixture of methylene chloride/diethyl ether (80/20), in presence of diazepam-d5, used as internal standard (IS). The hair extract was separated on an XTerra MS C18 column using a gradient of acetonitrile and formate buffer. Detection was based on two daughter ions: transitions m/z 256.2-152.1 and 167.1 and m/z 289.9-154.0 for diphenhydramine and the IS, respectively. In the hair of the child, diphenhydramine was detected at concentrations in the range 33-39 pg/mg, depending on the segment." @default.
- W2057254893 created "2016-06-24" @default.
- W2057254893 creator A5025381036 @default.
- W2057254893 creator A5028698750 @default.
- W2057254893 creator A5069667547 @default.
- W2057254893 creator A5080538122 @default.
- W2057254893 creator A5082201903 @default.
- W2057254893 date "2007-12-01" @default.
- W2057254893 modified "2023-10-16" @default.
- W2057254893 title "Hair analysis for diphenhydramine after surreptitious administration to a child" @default.
- W2057254893 cites W1484553115 @default.
- W2057254893 cites W1576374727 @default.
- W2057254893 cites W1975156050 @default.
- W2057254893 cites W2000827232 @default.
- W2057254893 cites W2020706113 @default.
- W2057254893 cites W2033799376 @default.
- W2057254893 cites W2046490553 @default.
- W2057254893 cites W2063955162 @default.
- W2057254893 cites W2100133070 @default.
- W2057254893 cites W2115685034 @default.
- W2057254893 cites W2123657713 @default.
- W2057254893 cites W2169624047 @default.
- W2057254893 doi "https://doi.org/10.1016/j.forsciint.2006.12.006" @default.
- W2057254893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17208400" @default.
- W2057254893 hasPublicationYear "2007" @default.
- W2057254893 type Work @default.
- W2057254893 sameAs 2057254893 @default.
- W2057254893 citedByCount "28" @default.
- W2057254893 countsByYear W20572548932012 @default.
- W2057254893 countsByYear W20572548932013 @default.
- W2057254893 countsByYear W20572548932014 @default.
- W2057254893 countsByYear W20572548932015 @default.
- W2057254893 countsByYear W20572548932016 @default.
- W2057254893 countsByYear W20572548932018 @default.
- W2057254893 countsByYear W20572548932023 @default.
- W2057254893 crossrefType "journal-article" @default.
- W2057254893 hasAuthorship W2057254893A5025381036 @default.
- W2057254893 hasAuthorship W2057254893A5028698750 @default.
- W2057254893 hasAuthorship W2057254893A5069667547 @default.
- W2057254893 hasAuthorship W2057254893A5080538122 @default.
- W2057254893 hasAuthorship W2057254893A5082201903 @default.
- W2057254893 hasConcept C1122143 @default.
- W2057254893 hasConcept C142724271 @default.
- W2057254893 hasConcept C185592680 @default.
- W2057254893 hasConcept C204787440 @default.
- W2057254893 hasConcept C2776814716 @default.
- W2057254893 hasConcept C2776880894 @default.
- W2057254893 hasConcept C2778000748 @default.
- W2057254893 hasConcept C2780852908 @default.
- W2057254893 hasConcept C2780884295 @default.
- W2057254893 hasConcept C2781292560 @default.
- W2057254893 hasConcept C2781400828 @default.
- W2057254893 hasConcept C42219234 @default.
- W2057254893 hasConcept C43617362 @default.
- W2057254893 hasConcept C71924100 @default.
- W2057254893 hasConcept C98274493 @default.
- W2057254893 hasConceptScore W2057254893C1122143 @default.
- W2057254893 hasConceptScore W2057254893C142724271 @default.
- W2057254893 hasConceptScore W2057254893C185592680 @default.
- W2057254893 hasConceptScore W2057254893C204787440 @default.
- W2057254893 hasConceptScore W2057254893C2776814716 @default.
- W2057254893 hasConceptScore W2057254893C2776880894 @default.
- W2057254893 hasConceptScore W2057254893C2778000748 @default.
- W2057254893 hasConceptScore W2057254893C2780852908 @default.
- W2057254893 hasConceptScore W2057254893C2780884295 @default.
- W2057254893 hasConceptScore W2057254893C2781292560 @default.
- W2057254893 hasConceptScore W2057254893C2781400828 @default.
- W2057254893 hasConceptScore W2057254893C42219234 @default.
- W2057254893 hasConceptScore W2057254893C43617362 @default.
- W2057254893 hasConceptScore W2057254893C71924100 @default.
- W2057254893 hasConceptScore W2057254893C98274493 @default.
- W2057254893 hasIssue "2-3" @default.
- W2057254893 hasLocation W20572548931 @default.
- W2057254893 hasLocation W20572548932 @default.
- W2057254893 hasOpenAccess W2057254893 @default.
- W2057254893 hasPrimaryLocation W20572548931 @default.
- W2057254893 hasRelatedWork W1972761954 @default.
- W2057254893 hasRelatedWork W1984568013 @default.
- W2057254893 hasRelatedWork W2271293499 @default.
- W2057254893 hasRelatedWork W2313963844 @default.
- W2057254893 hasRelatedWork W2335911900 @default.
- W2057254893 hasRelatedWork W2399653274 @default.
- W2057254893 hasRelatedWork W2412632302 @default.
- W2057254893 hasRelatedWork W2607419334 @default.
- W2057254893 hasRelatedWork W2993939901 @default.
- W2057254893 hasRelatedWork W4292805295 @default.
- W2057254893 hasVolume "173" @default.
- W2057254893 isParatext "false" @default.
- W2057254893 isRetracted "false" @default.
- W2057254893 magId "2057254893" @default.
- W2057254893 workType "article" @default.