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- W2057271611 abstract "A dimer of the 434 repressor bound at O(R)2 activated transcription initiation from P(RM) by contacting RNA polymerase. Although DNA-binding site mutations at either end of O(R)2 decreased the ability of the repressor to activate P(RM) transcription, mutations proximal to the promoter had a greater effect on transcription activation. Orienting a repressor subunit bearing the altered specificity Gln-28 --> Ala mutation to the halfsite of O(R)2 proximal to the P(RM) promoter decreased the repressor's ability to activate transcription initiation at 434 P(RM) to a much greater extent than if this subunit was placed in the O(R)2 half-site distal to P(RM). In addition to showing that the downstream (promoter proximal) subunit of the O(R)2-bound 434 repressor functions in activating 434 P(RM), the results indicated that DNA sequence-dependent conformational changes alter the efficiency with which the repressor activates P(RM) transcription. These unexpected findings highlight the importance of the structure of the repressor-DNA interface in activating transcription from P(RM)." @default.
- W2057271611 created "2016-06-24" @default.
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- W2057271611 date "2000-10-01" @default.
- W2057271611 modified "2023-09-27" @default.
- W2057271611 title "DNA Sequence Requirements for the Activation of 434 PRMTranscription by 434 Repressor" @default.
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- W2057271611 doi "https://doi.org/10.1089/104454900750019380" @default.
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