FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057281808> ?p ?o ?g. }

• W2057281808 endingPage "1019" @default.
• W2057281808 startingPage "1014" @default.
• W2057281808 abstract "This study was undertaken to characterize the serum levels of GH-binding protein (GHBP) before and during GH treatment in prepubertal short children born small for gestational age (SGA) and their relationship with growth parameters. Sixty-seven prepubertal short children (49 boys and 18 girls; height SD score, -5.4 to -2.0; age, 2.0-12.8 yr) born SGA, 8 of whom (6 boys and 2 girls) had signs of Silver-Russell syndrome, participated in the study. Total GHBP was measured by a ligand-mediated immunofunctional assay. The mean (SD) change in height SD score during the year before the start of GH treatment (0.1 IU/kg.day) was 0.11 (0.20) SD score, and this value increased to a 0.84 (0.43) SD score during the first year (P < 0.001) and to a 1.27 (0.63) SD score during the 2-yr period of therapy (P < 0.001). The baseline GHBP values ranged from 49-392 pmol/L, and no relationships were found among sex, chronological age, and maximal GH response to an arginine-insulin tolerance test. A positive correlation between GHBP and body composition, expressed as weight for height SD score, was found in the whole group (r = 0.28; P < 0.05) and in boys (r = 0.44; P < 0.01). No relationship was found between GHBP and spontaneous 24-h GH secretion, in terms of either GH secretion rate or pulsatile pattern, whereas GHBP was positively correlated with insulin-like growth factor I (IGF-I) SD score (r = 0.28; P < 0.05) and IGF-binding protein-3 SD score (r = 0.39; P < 0.01). Using a multiple stepwise linear regression analysis, the model using the IGF-binding protein-3 SD score and the weight for height SD score at the start of GH therapy accounted for 33% of the variance in the baseline GHBP values. A mean increase of 27 (51)% in GHBP levels was found after 1 yr of therapy. However, a high degree of variability in the response of individuals to GH treatment in terms of GHBP levels was observed: in some children GHBP levels increased, whereas in others they decreased. In conclusion, GHBP levels in short prepubertal children born SGA were mostly within the normal range previously reported and correlated directly with body composition. An increase in GHBP levels was observed during GH treatment in some SGA children. No correlation was found between pretreatment GHBP levels and growth response to GH treatment." @default.
• W2057281808 created "2016-06-24" @default.
• W2057281808 creator A5003306663 @default.
• W2057281808 creator A5012284318 @default.
• W2057281808 creator A5024377807 @default.
• W2057281808 creator A5051110265 @default.
• W2057281808 creator A5090194433 @default.
• W2057281808 date "1997-04-01" @default.
• W2057281808 modified "2023-09-23" @default.
• W2057281808 title "Growth Hormone (GH)-Binding Protein in Prepubertal Short Children Born Small for Gestational Age: Effects of Growth Hormone Treatment1" @default.
• W2057281808 cites W116867690 @default.
• W2057281808 cites W1869004865 @default.
• W2057281808 cites W192408054 @default.
• W2057281808 cites W1971352823 @default.
• W2057281808 cites W1978682854 @default.
• W2057281808 cites W1983374840 @default.
• W2057281808 cites W1986739790 @default.
• W2057281808 cites W1993776398 @default.
• W2057281808 cites W1995289334 @default.
• W2057281808 cites W1996657340 @default.
• W2057281808 cites W1998976611 @default.
• W2057281808 cites W2003116337 @default.
• W2057281808 cites W2006057791 @default.
• W2057281808 cites W2013014315 @default.
• W2057281808 cites W2016473857 @default.
• W2057281808 cites W2016539713 @default.
• W2057281808 cites W2019920503 @default.
• W2057281808 cites W2021868940 @default.
• W2057281808 cites W2024901631 @default.
• W2057281808 cites W2034960978 @default.
• W2057281808 cites W2037816029 @default.
• W2057281808 cites W2041882984 @default.
• W2057281808 cites W2059206304 @default.
• W2057281808 cites W2073178148 @default.
• W2057281808 cites W2077704944 @default.
• W2057281808 cites W2081972160 @default.
• W2057281808 cites W2086445805 @default.
• W2057281808 cites W2086683758 @default.
• W2057281808 cites W2089728262 @default.
• W2057281808 cites W2092221037 @default.
• W2057281808 cites W2098349892 @default.
• W2057281808 cites W2121383450 @default.
• W2057281808 cites W2133204828 @default.
• W2057281808 cites W2137194103 @default.
• W2057281808 cites W2169382158 @default.
• W2057281808 cites W2418053672 @default.
• W2057281808 doi "https://doi.org/10.1210/jcem.82.4.3902" @default.
• W2057281808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9100566" @default.
• W2057281808 hasPublicationYear "1997" @default.
• W2057281808 type Work @default.
• W2057281808 sameAs 2057281808 @default.
• W2057281808 citedByCount "3" @default.
• W2057281808 crossrefType "journal-article" @default.
• W2057281808 hasAuthorship W2057281808A5003306663 @default.
• W2057281808 hasAuthorship W2057281808A5012284318 @default.
• W2057281808 hasAuthorship W2057281808A5024377807 @default.
• W2057281808 hasAuthorship W2057281808A5051110265 @default.
• W2057281808 hasAuthorship W2057281808A5090194433 @default.
• W2057281808 hasBestOaLocation W20572818081 @default.
• W2057281808 hasConcept C113675107 @default.
• W2057281808 hasConcept C126322002 @default.
• W2057281808 hasConcept C134018914 @default.
• W2057281808 hasConcept C170493617 @default.
• W2057281808 hasConcept C2775960820 @default.
• W2057281808 hasConcept C2778135454 @default.
• W2057281808 hasConcept C2778328710 @default.
• W2057281808 hasConcept C2778376644 @default.
• W2057281808 hasConcept C2779234561 @default.
• W2057281808 hasConcept C2780378035 @default.
• W2057281808 hasConcept C2780689927 @default.
• W2057281808 hasConcept C2780938740 @default.
• W2057281808 hasConcept C2984496839 @default.
• W2057281808 hasConcept C54355233 @default.
• W2057281808 hasConcept C71315377 @default.
• W2057281808 hasConcept C71924100 @default.
• W2057281808 hasConcept C86803240 @default.
• W2057281808 hasConcept C89551170 @default.
• W2057281808 hasConceptScore W2057281808C113675107 @default.
• W2057281808 hasConceptScore W2057281808C126322002 @default.
• W2057281808 hasConceptScore W2057281808C134018914 @default.
• W2057281808 hasConceptScore W2057281808C170493617 @default.
• W2057281808 hasConceptScore W2057281808C2775960820 @default.
• W2057281808 hasConceptScore W2057281808C2778135454 @default.
• W2057281808 hasConceptScore W2057281808C2778328710 @default.
• W2057281808 hasConceptScore W2057281808C2778376644 @default.
• W2057281808 hasConceptScore W2057281808C2779234561 @default.
• W2057281808 hasConceptScore W2057281808C2780378035 @default.
• W2057281808 hasConceptScore W2057281808C2780689927 @default.
• W2057281808 hasConceptScore W2057281808C2780938740 @default.
• W2057281808 hasConceptScore W2057281808C2984496839 @default.
• W2057281808 hasConceptScore W2057281808C54355233 @default.
• W2057281808 hasConceptScore W2057281808C71315377 @default.
• W2057281808 hasConceptScore W2057281808C71924100 @default.
• W2057281808 hasConceptScore W2057281808C86803240 @default.
• W2057281808 hasConceptScore W2057281808C89551170 @default.
• W2057281808 hasIssue "4" @default.
• W2057281808 hasLocation W20572818081 @default.
• W2057281808 hasLocation W20572818082 @default.

• next