FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057285188> ?p ?o ?g. }

• W2057285188 endingPage "103" @default.
• W2057285188 startingPage "95" @default.
• W2057285188 abstract "Sabeluzole was described to have antiischemic, antiepileptic, and cognitive-enhancing properties, and is currently under development for Alzheimer's disease. Recently, it was reported that repeated treatments with sabeluzole protect cultured rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity. We evaluated the possibility that sabeluzole elicits neuroprotection by acting, either directly or indirectly, on tau proteins. We found that repeated treatments during development of primary cultures of cerebellar granule cells with nanomolar concentrations of sabeluzole resulted in mature cells that were resistant to the excitotoxicity induced by glutamate. Also, sabeluzole treatment specifically prevented the glutamate-induced increase of tau expression without modifying the basal pattern of expression of tau proteins, as shown by measurement of mRNA and protein levels. In human neuroblastoma cell line SH-SY5Y, differentiated by treatment with retinoic acid, doxorubicin increased tau immunoreactivity, and later induced cell death. Both effects were prevented by sabeluzole. Our data indicate that increased tau expression is a common response to different types of cells to neurotoxic agents, and that sabeluzole-induced neuroprotection is functionally associated with the prevention of the injury-mediated increase of tau expression." @default.
• W2057285188 created "2016-06-24" @default.
• W2057285188 creator A5023788664 @default.
• W2057285188 creator A5023874849 @default.
• W2057285188 creator A5037562311 @default.
• W2057285188 creator A5038684976 @default.
• W2057285188 creator A5042067785 @default.
• W2057285188 creator A5065628209 @default.
• W2057285188 creator A5074986039 @default.
• W2057285188 creator A5079505297 @default.
• W2057285188 date "1997-06-01" @default.
• W2057285188 modified "2023-09-24" @default.
• W2057285188 title "Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death" @default.
• W2057285188 cites W1514525963 @default.
• W2057285188 cites W1964562899 @default.
• W2057285188 cites W1966341306 @default.
• W2057285188 cites W1984827962 @default.
• W2057285188 cites W1994030229 @default.
• W2057285188 cites W1997197588 @default.
• W2057285188 cites W2000303735 @default.
• W2057285188 cites W2008675281 @default.
• W2057285188 cites W2013475161 @default.
• W2057285188 cites W2019246034 @default.
• W2057285188 cites W2023321924 @default.
• W2057285188 cites W2032568537 @default.
• W2057285188 cites W2046103490 @default.
• W2057285188 cites W2054092467 @default.
• W2057285188 cites W2060333964 @default.
• W2057285188 cites W2073046696 @default.
• W2057285188 cites W2085310707 @default.
• W2057285188 cites W2086716398 @default.
• W2057285188 cites W2090547876 @default.
• W2057285188 cites W2144136652 @default.
• W2057285188 cites W2144925005 @default.
• W2057285188 cites W2158060338 @default.
• W2057285188 cites W4294216491 @default.
• W2057285188 doi "https://doi.org/10.1002/(sici)1098-2396(199706)26:2<95::aid-syn1>3.0.co;2-8" @default.
• W2057285188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9131769" @default.
• W2057285188 hasPublicationYear "1997" @default.
• W2057285188 type Work @default.
• W2057285188 sameAs 2057285188 @default.
• W2057285188 citedByCount "12" @default.
• W2057285188 countsByYear W20572851882017 @default.
• W2057285188 countsByYear W20572851882019 @default.
• W2057285188 crossrefType "journal-article" @default.
• W2057285188 hasAuthorship W2057285188A5023788664 @default.
• W2057285188 hasAuthorship W2057285188A5023874849 @default.
• W2057285188 hasAuthorship W2057285188A5037562311 @default.
• W2057285188 hasAuthorship W2057285188A5038684976 @default.
• W2057285188 hasAuthorship W2057285188A5042067785 @default.
• W2057285188 hasAuthorship W2057285188A5065628209 @default.
• W2057285188 hasAuthorship W2057285188A5074986039 @default.
• W2057285188 hasAuthorship W2057285188A5079505297 @default.
• W2057285188 hasBestOaLocation W20572851882 @default.
• W2057285188 hasConcept C126322002 @default.
• W2057285188 hasConcept C148762608 @default.
• W2057285188 hasConcept C169760540 @default.
• W2057285188 hasConcept C170493617 @default.
• W2057285188 hasConcept C181199279 @default.
• W2057285188 hasConcept C185592680 @default.
• W2057285188 hasConcept C190283241 @default.
• W2057285188 hasConcept C25498285 @default.
• W2057285188 hasConcept C2776925932 @default.
• W2057285188 hasConcept C2778670691 @default.
• W2057285188 hasConcept C2779134260 @default.
• W2057285188 hasConcept C2779491297 @default.
• W2057285188 hasConcept C2780358027 @default.
• W2057285188 hasConcept C2781012912 @default.
• W2057285188 hasConcept C29730261 @default.
• W2057285188 hasConcept C31573885 @default.
• W2057285188 hasConcept C502032728 @default.
• W2057285188 hasConcept C54355233 @default.
• W2057285188 hasConcept C55493867 @default.
• W2057285188 hasConcept C61174792 @default.
• W2057285188 hasConcept C67018056 @default.
• W2057285188 hasConcept C71924100 @default.
• W2057285188 hasConcept C81885089 @default.
• W2057285188 hasConcept C86803240 @default.
• W2057285188 hasConcept C9497952 @default.
• W2057285188 hasConcept C95444343 @default.
• W2057285188 hasConcept C98274493 @default.
• W2057285188 hasConceptScore W2057285188C126322002 @default.
• W2057285188 hasConceptScore W2057285188C148762608 @default.
• W2057285188 hasConceptScore W2057285188C169760540 @default.
• W2057285188 hasConceptScore W2057285188C170493617 @default.
• W2057285188 hasConceptScore W2057285188C181199279 @default.
• W2057285188 hasConceptScore W2057285188C185592680 @default.
• W2057285188 hasConceptScore W2057285188C190283241 @default.
• W2057285188 hasConceptScore W2057285188C25498285 @default.
• W2057285188 hasConceptScore W2057285188C2776925932 @default.
• W2057285188 hasConceptScore W2057285188C2778670691 @default.
• W2057285188 hasConceptScore W2057285188C2779134260 @default.
• W2057285188 hasConceptScore W2057285188C2779491297 @default.
• W2057285188 hasConceptScore W2057285188C2780358027 @default.
• W2057285188 hasConceptScore W2057285188C2781012912 @default.
• W2057285188 hasConceptScore W2057285188C29730261 @default.
• W2057285188 hasConceptScore W2057285188C31573885 @default.
• W2057285188 hasConceptScore W2057285188C502032728 @default.

• next