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- W2057287863 abstract "Three injections monthly of 50 μg/ml hepatitis-B-vaccine (Hevac-B-Pasteur®) and one booster injection after 12 months from the beginning of vaccination were given to 676 adult recipients. Anti-HBs was detected in 45.9 percent of persons one month after the first dose of vaccine, in 79.3 percent after the third dose and in 98.4 percent after the booster injection. A follow-up of 142 persons 3 years after the first dose of vaccine indicated that protective levels of anti-HBs were maintained in 95.1 per cent of all participants. HLA antigens were typed in 13 vaccine recipients with low anti-HBs titers (≤ 10 ImU/ml) and in 26 recipients with high anti-HBs titers (≥20 000 ImU/ml). Significant differences of antigen frequency (p < 0.05) were found for HLA A3 (decrease in high responders), and HLA DR7 (increase of in low, decrease in high responders). The results indicate genetic differences between high and low responding recipients of HBV vaccine. Es wurden 676 erwachsene Personen mit einer Hepatitis-B-Vakzine (Hevac-B-Pasteur®) dreimal im Abstand von einem Monat sowie nach insgesamt einem Jahr noch einmal geimpft (jeweils 5 (μ/ml). Nach der ersten Injektion zeigten 45,9% der Impfteilnehmer eine Serokonversion, 79,3% nach der dritten Impfung und 98,4% nach der letzten Boostervakzination. 95,1% der Impfteilnehmer wiesen drei Jahre später noch ausreichende Antikörpertiter (anti-HBs) auf. Bei 13 Impfteilnehmern mit niedrigem anti-HBs-Titer (≤ 10 ImU/ml) sowie 26 Personen mit sehr hohen Titerwerten (≥ 20 000 ImU/ml) wurde im Vergleich zu 164 gesunden, nicht vakzinierten Kontrollpersonen eine HLA-Typisierung durchgeführt: Signifikante Unterschiede (p < 0,05) ergaben sich für HLA A3 (niedrigere Frequenz bei den stark Immunen) und HLA DR7 höhere Frequenz bei den schwach, niedrigere bei den stark Immunen)." @default.
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- W2057287863 date "1986-09-01" @default.
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- W2057287863 title "Humoral Immune Response After Hepatitis-B-Vaccination: Kinetics of Anti-HBS Antibodies and Demonstration of HLA Antigens" @default.
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- W2057287863 doi "https://doi.org/10.1016/s0176-6724(86)80011-6" @default.
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