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- W2057293378 abstract "To study the protective effect of resveratrol on endotoxemia-induced neurotoxicity.Rats were pre-treated during 7 days with 20 mg kg(-1) body weight (b.w.) resveratrol and challenged with a single dose of lipopolysaccharide (LPS: 8 mg kg(-1) b.w.) for 24 hours. Brains were harvested to determine LPS-induced lipoperoxidation level, antioxidant enzyme activities, nitric monoxide (NO) and iron distribution as well as the impact of resveratrol on these parameters.Resveratrol counteracted LPS-induced brain malondialdehyde (MDA) level and antioxidant enzyme activities depletion as superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD). Resveratrol also reversed LPS-induced brain and plasma NO elevation as well as iron sequestration from plasma to brain compartment.The data suggest that resveratrol is capable of alleviating LPS-induced neurotoxicity by a mechanism that may involve iron shuttling proteins." @default.
- W2057293378 created "2016-06-24" @default.
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- W2057293378 date "2009-01-01" @default.
- W2057293378 modified "2023-10-13" @default.
- W2057293378 title "Protective effect of resveratrol against lipopolysaccharide-induced oxidative stress in rat brain" @default.
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- W2057293378 doi "https://doi.org/10.3109/02699050903379370" @default.
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