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- W2057302019 endingPage "167" @default.
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- W2057302019 abstract "M-type (Kv7) K+ channels, encoded by KCNQ2–KCNQ5 genes, play a pivotal role in controlling neuronal excitability. However, precisely how neuronal activity regulates Kv7 channel translocation has not yet been fully defined. Here we reported activity-dependent changes in Kv7 channel subunits Kv7.2 and Kv7.3 surface expression by glutamate (glu). In the present study, we found that treatment with glutamate rapidly caused a specific decrease in M-current as well as Kv7 channel surface expression in primary cultured hippocampal neurons. The glutamate effects were mimicked by NMDA and AMPA. The glutamate effects on Kv7 channels were partially attenuated by pre-treatment of NMDA receptors antagonist d,l-APV or AMPA-KA receptors antagonist CNQX. The signal required Ca2+ influx through L-type Ca2+ channel and intracellular Ca2+ elevations. PKC activation was involved in the glutamate-induced reduction of Kv7 channel surface expression. Moreover, a significant reduction of Kv7 channel surface expression occurred following glycine-induced “chem”-LTP in vitro and hippocampus-dependent behavioral learning training in vivo. These results demonstrated that activity-dependent reduction of Kv7 channel surface expression through activation of ionotropic glutamate receptors (iGluRs)/Ca2+/PKC signaling pathway might be an important molecular mechanism for regulation of neuronal excitability and synaptic plasticity." @default.
- W2057302019 created "2016-06-24" @default.
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- W2057302019 date "2015-08-01" @default.
- W2057302019 modified "2023-10-14" @default.
- W2057302019 title "Activity-dependent downregulation of M-Type (Kv7) K+ channels surface expression requires the activation of iGluRs/Ca2+/PKC signaling pathway in hippocampal neuron" @default.
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- W2057302019 doi "https://doi.org/10.1016/j.neuropharm.2015.03.004" @default.
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