FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057303107> ?p ?o ?g. }

• W2057303107 endingPage "1171" @default.
• W2057303107 startingPage "1161" @default.
• W2057303107 abstract "The majority of luminal type breast carcinomas are slowly growing tumors with an overall favorable prognosis. However, a proportion of cases (luminal B tumors) are characterized by coactivation of growth factor receptors or non-canonical ER signaling and a poorer clinical outcome. The aim of our study was to evaluate whether the expression of proteins that are part of the ER signaling network may be used to distinguish low-risk from high-risk luminal tumors. Unsupervised hierarchical clustering of a set of proteins either involved in estrogen receptor signaling or associated with resistance to endocrine therapy was performed in a series of 443 postmenopausal breast carcinomas. Using this approach, we were able to reproduce the established classification with two distinct groups of luminal (estrogen receptor positive) tumors, one group of HER2-associated tumors and a group of triple-negative tumors. However, neither proliferation nor the expression of one or more of the ER-co-factors or resistance-associated factors, but PR-expression was identified as the most important stratifier distinguishing between the two luminal groups. In fact, not only the four identified clusters were shown to be significantly associated with patient outcome, PR-expression alone or in combination with Ki–67-stains stratified ER-positive tumors into a low-risk and a high-risk group. Our data indicate that defining luminal B tumors by the presence of high-risk criteria (loss of PR-expression or increased proliferation) provides a robust and highly significant stratification of ER-positive breast carcinomas into luminal A and B." @default.
• W2057303107 created "2016-06-24" @default.
• W2057303107 creator A5002219591 @default.
• W2057303107 creator A5008857505 @default.
• W2057303107 creator A5025409813 @default.
• W2057303107 creator A5026134240 @default.
• W2057303107 creator A5073405532 @default.
• W2057303107 creator A5081978650 @default.
• W2057303107 creator A5082614257 @default.
• W2057303107 creator A5089392438 @default.
• W2057303107 date "2013-09-01" @default.
• W2057303107 modified "2023-09-27" @default.
• W2057303107 title "Intrinsic breast cancer subtypes defined by estrogen receptor signalling—prognostic relevance of progesterone receptor loss" @default.
• W2057303107 cites W1581336962 @default.
• W2057303107 cites W1811094195 @default.
• W2057303107 cites W1971465952 @default.
• W2057303107 cites W1972385372 @default.
• W2057303107 cites W1977856207 @default.
• W2057303107 cites W1983271078 @default.
• W2057303107 cites W1989222913 @default.
• W2057303107 cites W1997006452 @default.
• W2057303107 cites W2009132910 @default.
• W2057303107 cites W2017811424 @default.
• W2057303107 cites W2018351534 @default.
• W2057303107 cites W2027953312 @default.
• W2057303107 cites W2063874882 @default.
• W2057303107 cites W2074820139 @default.
• W2057303107 cites W2079537380 @default.
• W2057303107 cites W2085921275 @default.
• W2057303107 cites W2088864187 @default.
• W2057303107 cites W2097255042 @default.
• W2057303107 cites W2105219549 @default.
• W2057303107 cites W2105882193 @default.
• W2057303107 cites W2116937653 @default.
• W2057303107 cites W2119769325 @default.
• W2057303107 cites W2121656289 @default.
• W2057303107 cites W2123179063 @default.
• W2057303107 cites W2127057139 @default.
• W2057303107 cites W2131964282 @default.
• W2057303107 cites W2131994307 @default.
• W2057303107 cites W2132619562 @default.
• W2057303107 cites W2132893003 @default.
• W2057303107 cites W2137853125 @default.
• W2057303107 cites W2139592878 @default.
• W2057303107 cites W2142146564 @default.
• W2057303107 cites W2143186560 @default.
• W2057303107 cites W2145552137 @default.
• W2057303107 cites W2146329585 @default.
• W2057303107 cites W2150134401 @default.
• W2057303107 cites W2152121590 @default.
• W2057303107 cites W2154462701 @default.
• W2057303107 doi "https://doi.org/10.1038/modpathol.2013.60" @default.
• W2057303107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23558572" @default.
• W2057303107 hasPublicationYear "2013" @default.
• W2057303107 type Work @default.
• W2057303107 sameAs 2057303107 @default.
• W2057303107 citedByCount "42" @default.
• W2057303107 countsByYear W20573031072013 @default.
• W2057303107 countsByYear W20573031072014 @default.
• W2057303107 countsByYear W20573031072015 @default.
• W2057303107 countsByYear W20573031072016 @default.
• W2057303107 countsByYear W20573031072017 @default.
• W2057303107 countsByYear W20573031072018 @default.
• W2057303107 countsByYear W20573031072019 @default.
• W2057303107 countsByYear W20573031072020 @default.
• W2057303107 countsByYear W20573031072021 @default.
• W2057303107 countsByYear W20573031072022 @default.
• W2057303107 countsByYear W20573031072023 @default.
• W2057303107 crossrefType "journal-article" @default.
• W2057303107 hasAuthorship W2057303107A5002219591 @default.
• W2057303107 hasAuthorship W2057303107A5008857505 @default.
• W2057303107 hasAuthorship W2057303107A5025409813 @default.
• W2057303107 hasAuthorship W2057303107A5026134240 @default.
• W2057303107 hasAuthorship W2057303107A5073405532 @default.
• W2057303107 hasAuthorship W2057303107A5081978650 @default.
• W2057303107 hasAuthorship W2057303107A5082614257 @default.
• W2057303107 hasAuthorship W2057303107A5089392438 @default.
• W2057303107 hasBestOaLocation W20573031071 @default.
• W2057303107 hasConcept C121608353 @default.
• W2057303107 hasConcept C126322002 @default.
• W2057303107 hasConcept C142724271 @default.
• W2057303107 hasConcept C143998085 @default.
• W2057303107 hasConcept C170493617 @default.
• W2057303107 hasConcept C172313692 @default.
• W2057303107 hasConcept C2777164284 @default.
• W2057303107 hasConcept C502942594 @default.
• W2057303107 hasConcept C530470458 @default.
• W2057303107 hasConcept C71924100 @default.
• W2057303107 hasConcept C84606932 @default.
• W2057303107 hasConcept C86803240 @default.
• W2057303107 hasConcept C98717036 @default.
• W2057303107 hasConceptScore W2057303107C121608353 @default.
• W2057303107 hasConceptScore W2057303107C126322002 @default.
• W2057303107 hasConceptScore W2057303107C142724271 @default.
• W2057303107 hasConceptScore W2057303107C143998085 @default.
• W2057303107 hasConceptScore W2057303107C170493617 @default.
• W2057303107 hasConceptScore W2057303107C172313692 @default.
• W2057303107 hasConceptScore W2057303107C2777164284 @default.

• next