FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057304417> ?p ?o ?g. }

• W2057304417 endingPage "200" @default.
• W2057304417 startingPage "186" @default.
• W2057304417 abstract "We investigated the potential of 4-AP (50-100 microM) to induce seizure-like events (SLEs) in combined entorhinal cortex-hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus. Slices from control rats (n=8) displayed SLEs in the entorhinal and perirhinal cortex upon application of 50 or 100 microM 4-AP. By contrast, 4-AP failed to induce SLEs in slices from chronic epileptic rats (n=13) except for one slice from one rat. This animal displayed only minor cell loss in layer III of the entorhinal cortex, in contrast to the other epileptic rats for which layer III neuronal loss was extensive. In all slices from epileptic rats, 4-AP induced recurrent epileptiform discharges similar to the interictal activity observed in control rats. Combined application of 4-AP (100 microM) and bicuculline methiodide (30 microM) induced frequent and prolonged recurrent epileptiform discharges in both control and chronic epileptic rats. 4-AP at 50-100 microM likely affects potassium channels containing Kv1.4, Kv1.5, Kv3.1 or Kv3.2 subunits. Real-time PCR revealed no significant downregulation of Kv1.4, Kv1.5, Kv3.1 or Kv3.2 in the subiculum, entorhinal and perirhinal cortex from chronic epileptic rats compared to controls. However, the expression of Kv3.4, responding to 4-AP in mM range, was significantly reduced. Using sub-unit-specific antibodies, the real-time PCR findings were confirmed by immunocytochemistry. We suggest that after chronic epilepsy, reorganization in the entorhinal cortex is accompanied by adaptations in homeostatic plasticity with anticonvulsant consequences." @default.
• W2057304417 created "2016-06-24" @default.
• W2057304417 creator A5001765166 @default.
• W2057304417 creator A5052394769 @default.
• W2057304417 creator A5079702745 @default.
• W2057304417 creator A5090031681 @default.
• W2057304417 creator A5091270897 @default.
• W2057304417 creator A5091662098 @default.
• W2057304417 date "2008-02-01" @default.
• W2057304417 modified "2023-10-02" @default.
• W2057304417 title "Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats" @default.
• W2057304417 cites W1512348246 @default.
• W2057304417 cites W1514853588 @default.
• W2057304417 cites W1520163941 @default.
• W2057304417 cites W1570612396 @default.
• W2057304417 cites W1583069828 @default.
• W2057304417 cites W174912705 @default.
• W2057304417 cites W1779991491 @default.
• W2057304417 cites W1822383484 @default.
• W2057304417 cites W1858330232 @default.
• W2057304417 cites W1963960938 @default.
• W2057304417 cites W1965688590 @default.
• W2057304417 cites W1966501910 @default.
• W2057304417 cites W1976763631 @default.
• W2057304417 cites W1978661886 @default.
• W2057304417 cites W1980828103 @default.
• W2057304417 cites W1982118871 @default.
• W2057304417 cites W1984695443 @default.
• W2057304417 cites W1986365306 @default.
• W2057304417 cites W1991558138 @default.
• W2057304417 cites W1993340311 @default.
• W2057304417 cites W1993460694 @default.
• W2057304417 cites W1997888430 @default.
• W2057304417 cites W2001233974 @default.
• W2057304417 cites W2005360876 @default.
• W2057304417 cites W2009332732 @default.
• W2057304417 cites W2011267914 @default.
• W2057304417 cites W2012958850 @default.
• W2057304417 cites W2015701831 @default.
• W2057304417 cites W2017053258 @default.
• W2057304417 cites W2021398460 @default.
• W2057304417 cites W2021599311 @default.
• W2057304417 cites W2021708054 @default.
• W2057304417 cites W2028226828 @default.
• W2057304417 cites W2034474299 @default.
• W2057304417 cites W2039200004 @default.
• W2057304417 cites W2040742860 @default.
• W2057304417 cites W2041109153 @default.
• W2057304417 cites W2055815530 @default.
• W2057304417 cites W2056571308 @default.
• W2057304417 cites W2057230367 @default.
• W2057304417 cites W2067091061 @default.
• W2057304417 cites W2067775848 @default.
• W2057304417 cites W2069917675 @default.
• W2057304417 cites W2077288667 @default.
• W2057304417 cites W2077801140 @default.
• W2057304417 cites W2078569891 @default.
• W2057304417 cites W2087199924 @default.
• W2057304417 cites W2088107588 @default.
• W2057304417 cites W2090966823 @default.
• W2057304417 cites W2092533498 @default.
• W2057304417 cites W2092700031 @default.
• W2057304417 cites W2093724234 @default.
• W2057304417 cites W2094529776 @default.
• W2057304417 cites W2099587101 @default.
• W2057304417 cites W2100784365 @default.
• W2057304417 cites W2103946141 @default.
• W2057304417 cites W2111405228 @default.
• W2057304417 cites W2114091591 @default.
• W2057304417 cites W2126468386 @default.
• W2057304417 cites W2127019545 @default.
• W2057304417 cites W2132338462 @default.
• W2057304417 cites W2135572946 @default.
• W2057304417 cites W2153110178 @default.
• W2057304417 cites W2155388215 @default.
• W2057304417 cites W2167139422 @default.
• W2057304417 cites W2171212714 @default.
• W2057304417 cites W2188438936 @default.
• W2057304417 cites W2226116716 @default.
• W2057304417 cites W2409462168 @default.
• W2057304417 cites W2415420325 @default.
• W2057304417 cites W4245660285 @default.
• W2057304417 cites W4322701228 @default.
• W2057304417 doi "https://doi.org/10.1016/j.nbd.2007.08.013" @default.
• W2057304417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17942314" @default.
• W2057304417 hasPublicationYear "2008" @default.
• W2057304417 type Work @default.
• W2057304417 sameAs 2057304417 @default.
• W2057304417 citedByCount "39" @default.
• W2057304417 countsByYear W20573044172012 @default.
• W2057304417 countsByYear W20573044172013 @default.
• W2057304417 countsByYear W20573044172014 @default.
• W2057304417 countsByYear W20573044172015 @default.
• W2057304417 countsByYear W20573044172016 @default.
• W2057304417 countsByYear W20573044172017 @default.
• W2057304417 countsByYear W20573044172018 @default.
• W2057304417 countsByYear W20573044172019 @default.
• W2057304417 countsByYear W20573044172020 @default.

• next