FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057305815> ?p ?o ?g. }

• W2057305815 abstract "We examined the expression of TNF-alpha within the substantia nigra pars reticulata (SNR) following intrastriatal injection of quinolinic acid (QA) and studied the effect of rolipram, a TNF-alpha-inhibitor, on the secondary neuronal damage. QA (240 nmol in 1 microl) was injected stereotactically into the striatum of male Wistar rats. After survival of 1, 3 or 10 days, the animals were sacrificed and immunohistochemical staining with an antibody against TNF-alpha was performed. From day 1 to day 10 after striatal QA injection TNF-alpha positive cells were observed within ipsilateral substantia nigra which were neither present on the contralateral side nor in sham-operated controls. Double labeling with antibodies against TNF-alpha and NeuN, keratan sulfate proteoglycan or GFAP displayed a good overlap between TNF-alpha and NeuN, which suggests that TNF-alpha positive cells are neurons. For the pharmacological approach, three groups of QA rats were treated intraperitoneally with either solvent (n=5), the NMDA receptor antagonist MK 801 (4 mg/kg, n=6) or the TNF-alpha inhibitor rolipram (0.3 mg/kg, n=6), which was started 24 h after QA-injection and continued with daily applications for 14 days. The amount of striatal damage did not differ between the three groups. The number of intact neurons within the ipsilateral substantia nigra of the solvent treated group was reduced by approximately 30% compared to the contralateral side. Both MK 801 and rolipram ameliorated this secondary damage and reduced the number of TNF-alpha positive cells. The observed association between expression of TNF-alpha and secondary neuronal damage within the substantia nigra induced by intrastriatal QA application might hint towards an involvement of this cytokine in transneuronal degeneration." @default.
• W2057305815 created "2016-06-24" @default.
• W2057305815 creator A5018627313 @default.
• W2057305815 creator A5049623249 @default.
• W2057305815 creator A5071934016 @default.
• W2057305815 creator A5072453940 @default.
• W2057305815 date "2004-02-01" @default.
• W2057305815 modified "2023-09-27" @default.
• W2057305815 title "Association between inflammation and nigral neuronal damage following striatal excitotoxic lesion" @default.
• W2057305815 cites W1598875012 @default.
• W2057305815 cites W1950744654 @default.
• W2057305815 cites W1972475601 @default.
• W2057305815 cites W1976467696 @default.
• W2057305815 cites W1978312717 @default.
• W2057305815 cites W1984466510 @default.
• W2057305815 cites W1992844146 @default.
• W2057305815 cites W1995778722 @default.
• W2057305815 cites W1998363366 @default.
• W2057305815 cites W2000420411 @default.
• W2057305815 cites W2005101685 @default.
• W2057305815 cites W2009948864 @default.
• W2057305815 cites W2015891893 @default.
• W2057305815 cites W2018865313 @default.
• W2057305815 cites W2021415666 @default.
• W2057305815 cites W2023396428 @default.
• W2057305815 cites W2024285818 @default.
• W2057305815 cites W2025960968 @default.
• W2057305815 cites W2040957577 @default.
• W2057305815 cites W2042141510 @default.
• W2057305815 cites W2066347230 @default.
• W2057305815 cites W2079192560 @default.
• W2057305815 cites W2080324970 @default.
• W2057305815 cites W2086526475 @default.
• W2057305815 cites W2086971298 @default.
• W2057305815 cites W2087804543 @default.
• W2057305815 cites W2100994529 @default.
• W2057305815 cites W2111471304 @default.
• W2057305815 cites W2123835255 @default.
• W2057305815 doi "https://doi.org/10.1016/j.brainres.2003.10.058" @default.
• W2057305815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14725965" @default.
• W2057305815 hasPublicationYear "2004" @default.
• W2057305815 type Work @default.
• W2057305815 sameAs 2057305815 @default.
• W2057305815 citedByCount "12" @default.
• W2057305815 countsByYear W20573058152012 @default.
• W2057305815 countsByYear W20573058152016 @default.
• W2057305815 countsByYear W20573058152018 @default.
• W2057305815 crossrefType "journal-article" @default.
• W2057305815 hasAuthorship W2057305815A5018627313 @default.
• W2057305815 hasAuthorship W2057305815A5049623249 @default.
• W2057305815 hasAuthorship W2057305815A5071934016 @default.
• W2057305815 hasAuthorship W2057305815A5072453940 @default.
• W2057305815 hasConcept C126322002 @default.
• W2057305815 hasConcept C134018914 @default.
• W2057305815 hasConcept C137183658 @default.
• W2057305815 hasConcept C142724271 @default.
• W2057305815 hasConcept C185592680 @default.
• W2057305815 hasConcept C204232928 @default.
• W2057305815 hasConcept C2776706248 @default.
• W2057305815 hasConcept C2777896816 @default.
• W2057305815 hasConcept C2780062018 @default.
• W2057305815 hasConcept C2780938664 @default.
• W2057305815 hasConcept C2781100881 @default.
• W2057305815 hasConcept C2781156865 @default.
• W2057305815 hasConcept C513476851 @default.
• W2057305815 hasConcept C515207424 @default.
• W2057305815 hasConcept C55493867 @default.
• W2057305815 hasConcept C71924100 @default.
• W2057305815 hasConcept C98274493 @default.
• W2057305815 hasConceptScore W2057305815C126322002 @default.
• W2057305815 hasConceptScore W2057305815C134018914 @default.
• W2057305815 hasConceptScore W2057305815C137183658 @default.
• W2057305815 hasConceptScore W2057305815C142724271 @default.
• W2057305815 hasConceptScore W2057305815C185592680 @default.
• W2057305815 hasConceptScore W2057305815C204232928 @default.
• W2057305815 hasConceptScore W2057305815C2776706248 @default.
• W2057305815 hasConceptScore W2057305815C2777896816 @default.
• W2057305815 hasConceptScore W2057305815C2780062018 @default.
• W2057305815 hasConceptScore W2057305815C2780938664 @default.
• W2057305815 hasConceptScore W2057305815C2781100881 @default.
• W2057305815 hasConceptScore W2057305815C2781156865 @default.
• W2057305815 hasConceptScore W2057305815C513476851 @default.
• W2057305815 hasConceptScore W2057305815C515207424 @default.
• W2057305815 hasConceptScore W2057305815C55493867 @default.
• W2057305815 hasConceptScore W2057305815C71924100 @default.
• W2057305815 hasConceptScore W2057305815C98274493 @default.
• W2057305815 hasLocation W20573058151 @default.
• W2057305815 hasLocation W20573058152 @default.
• W2057305815 hasOpenAccess W2057305815 @default.
• W2057305815 hasPrimaryLocation W20573058151 @default.
• W2057305815 hasRelatedWork W1979747151 @default.
• W2057305815 hasRelatedWork W1990471595 @default.
• W2057305815 hasRelatedWork W1991152512 @default.
• W2057305815 hasRelatedWork W1996006408 @default.
• W2057305815 hasRelatedWork W2008995925 @default.
• W2057305815 hasRelatedWork W2011880654 @default.
• W2057305815 hasRelatedWork W2088863630 @default.
• W2057305815 hasRelatedWork W2093047883 @default.
• W2057305815 hasRelatedWork W2899084033 @default.
• W2057305815 hasRelatedWork W3148633927 @default.

• next