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• W2057315471 abstract "Impaired electron transport chain function has been related to increases in reactive oxygen species (ROS) generation. Here we analyzed different pet mutants of Saccharomyces cerevisiae in order to determine the relative contribution of respiratory chain components in ROS generation and removal. We found that the maintenance of respiration strongly prevented mitochondrial H(2)O(2) release and increased cellular H(2)O(2) removal. Among all respiratory-deficient strains analyzed, cells lacking cytochrome c (cyc3 point mutants) presented the highest level of H(2)O(2) synthesis, indicating that the absence of functional cytochrome c in mitochondria leads to oxidative stress. This finding was supported by the presence of high levels of catalase and peroxidase activity despite the lack of respiration. Furthermore, the addition of exogenous cytochrome c to isolated yeast mitoplasts significantly reduced H(2)O(2) detection in a manner enhanced by cytochrome c reduction and the presence of a functional respiratory chain. Together, our results indicate that the maintenance of electron transport by cytochrome c prevents ROS generation by the respiratory chain." @default.
• W2057315471 created "2016-06-24" @default.
• W2057315471 creator A5049076742 @default.
• W2057315471 creator A5051359796 @default.
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• W2057315471 date "2003-07-15" @default.
• W2057315471 modified "2023-09-27" @default.
• W2057315471 title "H2O2 generation in Saccharomyces cerevisiae respiratory pet mutants: effect of cytochrome c" @default.
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• W2057315471 doi "https://doi.org/10.1016/s0891-5849(03)00307-1" @default.
• W2057315471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12853074" @default.
• W2057315471 hasPublicationYear "2003" @default.
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