FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057316583> ?p ?o ?g. }

• W2057316583 endingPage "53" @default.
• W2057316583 startingPage "44" @default.
• W2057316583 abstract "We investigated the genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute (4 days) exposure to 0.1 or 1.0 μg/L of 17β-trenbolone (TB), the active metabolite of an anabolic androgenic steroid used as a growth promoter in cattle and a contaminant of concern in aquatic systems. Our objectives were to investigate the gene expression profile induced by TB, define biomarkers of exposure to TB, and increase our understanding of the mechanisms of adverse effects of TB on fish reproduction. In female gonad tissue, microarray analysis using a 22 K oligonucleotide microarray (EcoArray Inc., Gainesville, FL) showed 99 significantly upregulated genes and 741 significantly downregulated genes in response to 1 μg TB/L. In particular, hydroxysteroid (17β) dehydrogenase 12a (hsd17b12a), zona pellucida glycoprotein 2.2 (zp2.2), and protein inhibitor of activated STAT, 2 (pias2) were all downregulated in gonad. Q-PCR measurements in a larger sample set were consistent with the microarray results in the direction and magnitude of these changes in gene expression. However, several novel potential biomarkers were verified by Q-PCR in the same samples, but could not be validated in independent samples. In liver, Q-PCR measurements showed a significant decrease in vitellogenin 1 (vtg1) mRNA expression. In brain, cytochrome P450, family 19, subfamily A, polypeptide 1b (cyp19a1b, previously known as aromatase B) transcript levels were significantly reduced following TB exposure. Our study provides a candidate gene involved in mediating the action of TB, hsd17b12a, and two potential biomarkers sensitive to acute TB exposure, hepatic vtg1 and brain cyp19a1b." @default.
• W2057316583 created "2016-06-24" @default.
• W2057316583 creator A5019109097 @default.
• W2057316583 creator A5024460098 @default.
• W2057316583 creator A5028994823 @default.
• W2057316583 creator A5050149254 @default.
• W2057316583 creator A5051169764 @default.
• W2057316583 creator A5072471830 @default.
• W2057316583 date "2009-01-01" @default.
• W2057316583 modified "2023-09-26" @default.
• W2057316583 title "The genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute exposure to the androgen, 17β-trenbolone" @default.
• W2057316583 cites W1494222293 @default.
• W2057316583 cites W1579401963 @default.
• W2057316583 cites W1974506546 @default.
• W2057316583 cites W1992096727 @default.
• W2057316583 cites W2000849916 @default.
• W2057316583 cites W2002810210 @default.
• W2057316583 cites W2003119294 @default.
• W2057316583 cites W2008183439 @default.
• W2057316583 cites W2019234246 @default.
• W2057316583 cites W2024494058 @default.
• W2057316583 cites W2037001136 @default.
• W2057316583 cites W2038711150 @default.
• W2057316583 cites W2038894740 @default.
• W2057316583 cites W2042161432 @default.
• W2057316583 cites W2044112975 @default.
• W2057316583 cites W2047648686 @default.
• W2057316583 cites W2048844348 @default.
• W2057316583 cites W2055043387 @default.
• W2057316583 cites W2056106234 @default.
• W2057316583 cites W2058335420 @default.
• W2057316583 cites W2059477274 @default.
• W2057316583 cites W2059651883 @default.
• W2057316583 cites W2062465036 @default.
• W2057316583 cites W2071098268 @default.
• W2057316583 cites W2080906990 @default.
• W2057316583 cites W2087388899 @default.
• W2057316583 cites W2100623909 @default.
• W2057316583 cites W2103017472 @default.
• W2057316583 cites W2103941692 @default.
• W2057316583 cites W2106178221 @default.
• W2057316583 cites W2114090345 @default.
• W2057316583 cites W2120568877 @default.
• W2057316583 cites W2124565523 @default.
• W2057316583 cites W2128633243 @default.
• W2057316583 cites W2134034608 @default.
• W2057316583 cites W2136238203 @default.
• W2057316583 cites W2136881537 @default.
• W2057316583 cites W2139631347 @default.
• W2057316583 cites W2139685584 @default.
• W2057316583 cites W2142630077 @default.
• W2057316583 cites W2144573936 @default.
• W2057316583 cites W2146352944 @default.
• W2057316583 cites W2153895746 @default.
• W2057316583 cites W2159778518 @default.
• W2057316583 cites W21787296 @default.
• W2057316583 cites W4252724650 @default.
• W2057316583 cites W4253601422 @default.
• W2057316583 doi "https://doi.org/10.1016/j.aquatox.2008.10.002" @default.
• W2057316583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747603" @default.
• W2057316583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19019464" @default.
• W2057316583 hasPublicationYear "2009" @default.
• W2057316583 type Work @default.
• W2057316583 sameAs 2057316583 @default.
• W2057316583 citedByCount "42" @default.
• W2057316583 countsByYear W20573165832012 @default.
• W2057316583 countsByYear W20573165832013 @default.
• W2057316583 countsByYear W20573165832014 @default.
• W2057316583 countsByYear W20573165832015 @default.
• W2057316583 countsByYear W20573165832016 @default.
• W2057316583 countsByYear W20573165832017 @default.
• W2057316583 countsByYear W20573165832018 @default.
• W2057316583 countsByYear W20573165832019 @default.
• W2057316583 countsByYear W20573165832021 @default.
• W2057316583 countsByYear W20573165832022 @default.
• W2057316583 crossrefType "journal-article" @default.
• W2057316583 hasAuthorship W2057316583A5019109097 @default.
• W2057316583 hasAuthorship W2057316583A5024460098 @default.
• W2057316583 hasAuthorship W2057316583A5028994823 @default.
• W2057316583 hasAuthorship W2057316583A5050149254 @default.
• W2057316583 hasAuthorship W2057316583A5051169764 @default.
• W2057316583 hasAuthorship W2057316583A5072471830 @default.
• W2057316583 hasBestOaLocation W20573165832 @default.
• W2057316583 hasConcept C104317684 @default.
• W2057316583 hasConcept C121608353 @default.
• W2057316583 hasConcept C126322002 @default.
• W2057316583 hasConcept C134018914 @default.
• W2057316583 hasConcept C150194340 @default.
• W2057316583 hasConcept C153911025 @default.
• W2057316583 hasConcept C186836561 @default.
• W2057316583 hasConcept C2776166826 @default.
• W2057316583 hasConcept C2776451064 @default.
• W2057316583 hasConcept C2776878037 @default.
• W2057316583 hasConcept C2777911890 @default.
• W2057316583 hasConcept C2779078696 @default.
• W2057316583 hasConcept C2779279991 @default.
• W2057316583 hasConcept C2780384893 @default.
• W2057316583 hasConcept C2781471917 @default.

• next