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• W2057322928 abstract "Small molecule mGluR1 enhancers, which are 9H-xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides, have been previously reported. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides with improved pharmacokinetic properties have been designed and synthesized as useful pharmacological tools for the study of the physiological roles mediated by mGlu1 receptors. The synthesis and the structure–activity relationship of this class of positive allosteric modulators of mGlu1 receptors will be discussed in detail." @default.
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• W2057322928 date "2009-03-01" @default.
• W2057322928 modified "2023-09-28" @default.
• W2057322928 title "Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers" @default.
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• W2057322928 doi "https://doi.org/10.1016/j.bmcl.2009.01.108" @default.
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