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• W2057323930 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Dec 2001A COMPARISON OF 1.5% GLYCINE AND 2.7% SORBITOL-0.5% MANNITOL IRRIGANTS DURING TRANSURETHRAL PROSTATE RESECTION R.D. INMAN, Z. HUSSAIN, A.W.S. ELVES, M.J. HALLWORTH, P.W. JONES, and S.W. V. COPPINGER R.D. INMANR.D. INMAN Financial interest and/or other relationship with Sanofi Synthelabo and Fresenius Kabi, Ltd. More articles by this author , Z. HUSSAINZ. HUSSAIN Financial interest and/or other relationship with Gyrus Medical, Ltd., Sanofi Synthelabo, Fresenius Kabi, Ltd., Wyeth Laboratories and Zeneca Pharmaceutical. More articles by this author , A.W.S. ELVESA.W.S. ELVES Financial interest and/or other relationship with Zeneca Pharmaceutical and Glaxo. More articles by this author , M.J. HALLWORTHM.J. HALLWORTH Financial interest and/or other relationship with Abbott Diagnostics. More articles by this author , P.W. JONESP.W. JONES More articles by this author , and S.W. V. COPPINGERS.W. V. COPPINGER More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65537-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We performed a prospective randomized trial comparing glycine 1.5% with 2.7% sorbitol-0.5% mannitol irrigating solution. We evaluated blood loss, fluid absorption, temperature change, cardiac effects and postoperative symptoms. Materials and Methods: Between April 1998 and July 1999, 205 treated patients were included in the statistical analysis. Intraoperative irrigating fluid absorption was measured with the patient on the operating table. Serum cardiac troponin I was used as a marker of perioperative myocardial damage. Operative details were recorded, including the type of anesthesia, resection time and the weight of resected tissue. Postoperative symptoms were documented prospectively. Results: Mean patient age was not significantly different in the glycine and sorbitol-mannitol groups. (72.1 versus 73.7 years). American Society of Anesthesiologists grade was also comparable. Median resection time was 27 minutes and resected tissue weighed a mean of 21 gm. The median resection rate was 0.8 gm. per minute. Blood loss and temperature changes during resection were similar in the 2 groups. Overall median blood loss was 216 ml. and irrigant absorption was 140 ml. In the sorbitol-mannitol group significantly less fluid was apparently absorbed during resection (median 88.2 versus 184.4 ml.). Analysis of the incidence of symptoms of the transurethral prostate resection syndrome did not show any differences in the irrigant groups. Cardiac damage measured using troponin I also showed no significant difference in the 2 groups, although there was a high overall incidence of 7.5%. Conclusions: We noted no significant differences in 1.5% glycine and 2.7% sorbitol-0.5% mannitol as an irrigating solution for transurethral prostate resection. References 1 : Symptoms of the transurethral resection syndrome using glycine as the irrigant. J Urol1995; 154: 123. Link, Google Scholar 2 : Double blind randomized study of symptoms associated with absorption of glycine 1.5% or mannitol 3% during transurethral resection of the prostate. J Urol1998; 160: 397. Link, Google Scholar 3 : Intravenous infusion of irrigating fluids containing glycine or mannitol with and without ethanol. J Urol1989; 142: 1102. Link, Google Scholar 4 : Effect of irrigating fluids and prostate tissue extracts on isolated cardiomyocytes. Urology1995; 46: 821. Google Scholar 5 : ‘Double toxicity’ of glycine solution in the mouse. Br J Urol1996; 77: 203. Google Scholar 6 : The use of glycine solution as an irrigating solution during transurethral resection. J Urol1948; 59: 1212. 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Google Scholar From the Departments of Urology and Clinical Biochemistry, Royal Shrewsbury Hospital, Shrewsbury and Department of Mathematics, Keele University, Keele, United Kingdom© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByCollins J, MacDermott S, Bradbrook R, Drake B, Keeley F and Timoney A (2018) The Effect of the Choice of Irrigation Fluid on Cardiac Stress During Transurethral Resection of the Prostate: A Comparison Between 1.5% Glycine and 5% GlucoseJournal of Urology, VOL. 177, NO. 4, (1369-1373), Online publication date: 1-Apr-2007.MANIKANDAN R, NATHANIEL C, LEWIS P, BROUGH R, ADEYOJU A, BROWN S, O’REILLY P and COLLINS G (2018) TROPONIN T AND N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE CHANGES IN PATIENTS UNDERGOING TRANSURETHRAL RESECTION OF THE PROSTATEJournal of Urology, VOL. 174, NO. 5, (1892-1895), Online publication date: 1-Nov-2005.SHIOZAWA H, AIZAWA T, ITO T and MIKI M (2018) A New Transurethral Resection System: Operating in Saline Environment Precludes Obturator Nerve ReflexesJournal of Urology, VOL. 168, NO. 6, (2665-2667), Online publication date: 1-Dec-2002. Volume 166Issue 6December 2001Page: 2216-2220 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordstransurethral resection of prostatesorbitolmannitolglycineprostateMetricsAuthor Information R.D. INMAN Financial interest and/or other relationship with Sanofi Synthelabo and Fresenius Kabi, Ltd. More articles by this author Z. HUSSAIN Financial interest and/or other relationship with Gyrus Medical, Ltd., Sanofi Synthelabo, Fresenius Kabi, Ltd., Wyeth Laboratories and Zeneca Pharmaceutical. More articles by this author A.W.S. ELVES Financial interest and/or other relationship with Zeneca Pharmaceutical and Glaxo. More articles by this author M.J. HALLWORTH Financial interest and/or other relationship with Abbott Diagnostics. More articles by this author P.W. JONES More articles by this author S.W. V. COPPINGER More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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