FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057324918> ?p ?o ?g. }

• W2057324918 endingPage "733" @default.
• W2057324918 startingPage "727" @default.
• W2057324918 abstract "Background Estrogen plays a major role in the delayed expression of coronary heart disease (CHD) in women, and recent data indicate that postmenopausal estrogen therapy reduces the incidence of CHD by >40%. The mechanism or mechanisms through which estrogen exerts this benefit are unknown, although effects on blood pressure, carbohydrate and lipid metabolism, and coagulation have been suggested. We hypothesized that at least part of the effect of estrogen in reducing the incidence of CHD is due to an effect on endothelial cell function. Methods and Results In the present study, we examined human aortic and umbilical vein endothelial cells and bovine aortic endothelial cells for the presence of estrogen receptors (ERs) through immunoblot and mRNA analyses. Electrophoretic mobility shift assays were also performed to determine the DNA-binding properties of the putative ERs. Nuclear extracts from all three endothelial cell types were found to contain a 67-kD protein that reacted with anti-ER monoclonal antibodies specific to different domains of the ERs. Each of these types of cells expresses proteins that bind specifically to consensus estrogen-responsive elements. Finally, Northern blots verified that endothelial cells express abundant amount of mRNA for the ER. Conclusions These data indicate that endothelial cells constitutively possess the potential for transcriptional regulation of target genes by estrogen. The evolutionary conservation of this receptor in bovine and human endothelial cells suggests a common mechanism for estrogen regulation of endothelial function." @default.
• W2057324918 created "2016-06-24" @default.
• W2057324918 creator A5039275729 @default.
• W2057324918 creator A5061728462 @default.
• W2057324918 creator A5069316598 @default.
• W2057324918 date "1996-08-15" @default.
• W2057324918 modified "2023-09-23" @default.
• W2057324918 title "Identification of Authentic Estrogen Receptor in Cultured Endothelial Cells" @default.
• W2057324918 cites W1510421758 @default.
• W2057324918 cites W1560420809 @default.
• W2057324918 cites W1585603261 @default.
• W2057324918 cites W1971529500 @default.
• W2057324918 cites W1976495127 @default.
• W2057324918 cites W1978382386 @default.
• W2057324918 cites W1982597476 @default.
• W2057324918 cites W1982925298 @default.
• W2057324918 cites W1987144846 @default.
• W2057324918 cites W1987623753 @default.
• W2057324918 cites W1988094018 @default.
• W2057324918 cites W1996455583 @default.
• W2057324918 cites W1999455210 @default.
• W2057324918 cites W1999962551 @default.
• W2057324918 cites W2010309484 @default.
• W2057324918 cites W2011210257 @default.
• W2057324918 cites W2011710396 @default.
• W2057324918 cites W2015199849 @default.
• W2057324918 cites W2015789469 @default.
• W2057324918 cites W2016054237 @default.
• W2057324918 cites W2022121555 @default.
• W2057324918 cites W2028507406 @default.
• W2057324918 cites W2030158759 @default.
• W2057324918 cites W2036246319 @default.
• W2057324918 cites W2040074029 @default.
• W2057324918 cites W2063014237 @default.
• W2057324918 cites W2063031738 @default.
• W2057324918 cites W2068113812 @default.
• W2057324918 cites W2068653484 @default.
• W2057324918 cites W2068921569 @default.
• W2057324918 cites W2081501399 @default.
• W2057324918 cites W2082603208 @default.
• W2057324918 cites W2082800134 @default.
• W2057324918 cites W2083578330 @default.
• W2057324918 cites W2087777674 @default.
• W2057324918 cites W2097246067 @default.
• W2057324918 cites W2100837269 @default.
• W2057324918 cites W2132185105 @default.
• W2057324918 cites W2139319235 @default.
• W2057324918 cites W2153550326 @default.
• W2057324918 cites W2164319707 @default.
• W2057324918 cites W2415414147 @default.
• W2057324918 cites W4255507315 @default.
• W2057324918 doi "https://doi.org/10.1161/01.cir.94.4.727" @default.
• W2057324918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8772695" @default.
• W2057324918 hasPublicationYear "1996" @default.
• W2057324918 type Work @default.
• W2057324918 sameAs 2057324918 @default.
• W2057324918 citedByCount "296" @default.
• W2057324918 countsByYear W20573249182012 @default.
• W2057324918 countsByYear W20573249182013 @default.
• W2057324918 countsByYear W20573249182014 @default.
• W2057324918 countsByYear W20573249182015 @default.
• W2057324918 countsByYear W20573249182016 @default.
• W2057324918 countsByYear W20573249182017 @default.
• W2057324918 countsByYear W20573249182018 @default.
• W2057324918 countsByYear W20573249182019 @default.
• W2057324918 countsByYear W20573249182021 @default.
• W2057324918 countsByYear W20573249182022 @default.
• W2057324918 crossrefType "journal-article" @default.
• W2057324918 hasAuthorship W2057324918A5039275729 @default.
• W2057324918 hasAuthorship W2057324918A5061728462 @default.
• W2057324918 hasAuthorship W2057324918A5069316598 @default.
• W2057324918 hasConcept C121608353 @default.
• W2057324918 hasConcept C123012128 @default.
• W2057324918 hasConcept C126322002 @default.
• W2057324918 hasConcept C134018914 @default.
• W2057324918 hasConcept C170493617 @default.
• W2057324918 hasConcept C172313692 @default.
• W2057324918 hasConcept C202751555 @default.
• W2057324918 hasConcept C2776992346 @default.
• W2057324918 hasConcept C2777164284 @default.
• W2057324918 hasConcept C2777411675 @default.
• W2057324918 hasConcept C530470458 @default.
• W2057324918 hasConcept C55493867 @default.
• W2057324918 hasConcept C71924100 @default.
• W2057324918 hasConcept C84606932 @default.
• W2057324918 hasConcept C86803240 @default.
• W2057324918 hasConcept C95444343 @default.
• W2057324918 hasConcept C96307122 @default.
• W2057324918 hasConceptScore W2057324918C121608353 @default.
• W2057324918 hasConceptScore W2057324918C123012128 @default.
• W2057324918 hasConceptScore W2057324918C126322002 @default.
• W2057324918 hasConceptScore W2057324918C134018914 @default.
• W2057324918 hasConceptScore W2057324918C170493617 @default.
• W2057324918 hasConceptScore W2057324918C172313692 @default.
• W2057324918 hasConceptScore W2057324918C202751555 @default.
• W2057324918 hasConceptScore W2057324918C2776992346 @default.
• W2057324918 hasConceptScore W2057324918C2777164284 @default.
• W2057324918 hasConceptScore W2057324918C2777411675 @default.

• next