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• W2057331139 abstract "Numerous epidemiological studies have demonstrated the atheroprotective roles of high density lipoproteins (HDL), so that HDL is established as an independent negative risk factor. The protective effect of HDL against atherosclerosis is mainly attributed to their capacity to bring peripheral excess cholesterol back to the liver for further elimination into the bile. In addition, HDL can exert other protective functions on the vascular wall, through their anti-inflammatory, antioxidant, antithrombotic and cytoprotective properties. HDL-targeted therapy is thus an innovative approach against cardiovascular risk and atherosclerosis. These pleiotropic atheroprotective properties of HDL have led experts to believe that “HDL-related therapies” represent the most promising next step in fighting against atherosclerosis. However, because of the heterogeneity of HDL functions, targeting HDL is not a simple task and HDL therapies that lower cardiovascular risk are NOT yet available. In this paper, an overview is presented about the therapeutic strategies currently under consideration to raise HDL levels and/or functions. Recently, clinical trials of drugs targeting HDL-C levels have disappointingly failed, suggesting that HDL functions through specific mechanisms should be targeted rather than increasing per se HDL levels. Le rôle athéroprotecteur des lipoprotéines de haute densité (HDL) est maintenant largement démontré par les études épidémiologiques. Cet effet bénéfique est principalement attribué à la fonction des HDL dans le transporteur retour du cholestérol, des cellules périphériques, notamment les macrophages de la paroi artérielle, vers le foie, où il est ensuite éliminé via les voies biliaires. En outre, a été démontré que les HDL possèdent de nombreux effets pléïotropes telles que des activités anti-inflammatoires, anti-oxydantes, anti-thrombotiques ou cyto-protectrices. Cibler spécifiquement les HDL pourrait constituer une approche innovante dans la lutte contre l’athérosclérose et le risque cardiovasculaire. Cependant, en raison de l’hétérogénéité de leurs fonctions, cibler les HDL n’est pas un objectif simple. Cet article vise à présenter les stratégies actuellement à l’étude, celles-ci ayant pour objectif, soit d’augmenter les concentrations circulantes de HDL-cholestérol (HDL-C), soit de moduler les fonctions de ces lipoprotéines. Des essais cliniques récents, portant sur des molécules augmentant les taux de HDL-C, n’ont pas permis de conclure de manière claire à une efficacité dans la réduction du risque cardiovasculaire. Cela semble donc suggérer que ce sont les fonctions des HDL qui devraient être ciblées plutôt que simplement l’élévation de leur concentration." @default.
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• W2057331139 date "2013-11-01" @default.
• W2057331139 modified "2023-09-30" @default.
• W2057331139 title "Targeting high-density lipoproteins: Update on a promising therapy" @default.
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• W2057331139 doi "https://doi.org/10.1016/j.acvd.2013.06.052" @default.
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