FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057340929> ?p ?o ?g. }

• W2057340929 endingPage "e1003594" @default.
• W2057340929 startingPage "e1003594" @default.
• W2057340929 abstract "Many disease-associated variants affect gene expression levels (expression quantitative trait loci, eQTLs) and expression profiling using next generation sequencing (NGS) technology is a powerful way to detect these eQTLs. We analyzed 94 total blood samples from healthy volunteers with DeepSAGE to gain specific insight into how genetic variants affect the expression of genes and lengths of 3'-untranslated regions (3'-UTRs). We detected previously unknown cis-eQTL effects for GWAS hits in disease- and physiology-associated traits. Apart from cis-eQTLs that are typically easily identifiable using microarrays or RNA-sequencing, DeepSAGE also revealed many cis-eQTLs for antisense and other non-coding transcripts, often in genomic regions containing retrotransposon-derived elements. We also identified and confirmed SNPs that affect the usage of alternative polyadenylation sites, thereby potentially influencing the stability of messenger RNAs (mRNA). We then combined the power of RNA-sequencing with DeepSAGE by performing a meta-analysis of three datasets, leading to the identification of many more cis-eQTLs. Our results indicate that DeepSAGE data is useful for eQTL mapping of known and unknown transcripts, and for identifying SNPs that affect alternative polyadenylation. Because of the inherent differences between DeepSAGE and RNA-sequencing, our complementary, integrative approach leads to greater insight into the molecular consequences of many disease-associated variants." @default.
• W2057340929 created "2016-06-24" @default.
• W2057340929 creator A5006321682 @default.
• W2057340929 creator A5008602701 @default.
• W2057340929 creator A5008955525 @default.
• W2057340929 creator A5019130914 @default.
• W2057340929 creator A5026121576 @default.
• W2057340929 creator A5029024758 @default.
• W2057340929 creator A5035504682 @default.
• W2057340929 creator A5038334172 @default.
• W2057340929 creator A5040120668 @default.
• W2057340929 creator A5042714049 @default.
• W2057340929 creator A5047168944 @default.
• W2057340929 creator A5052688583 @default.
• W2057340929 creator A5055183685 @default.
• W2057340929 creator A5055691889 @default.
• W2057340929 creator A5069816083 @default.
• W2057340929 creator A5070233617 @default.
• W2057340929 creator A5076062731 @default.
• W2057340929 creator A5079752137 @default.
• W2057340929 creator A5088404253 @default.
• W2057340929 date "2013-06-20" @default.
• W2057340929 modified "2023-10-14" @default.
• W2057340929 title "DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts" @default.
• W2057340929 cites W1934547378 @default.
• W2057340929 cites W1963738161 @default.
• W2057340929 cites W1964727443 @default.
• W2057340929 cites W1972698844 @default.
• W2057340929 cites W1975802043 @default.
• W2057340929 cites W1981509058 @default.
• W2057340929 cites W1999676455 @default.
• W2057340929 cites W2002382034 @default.
• W2057340929 cites W2002599289 @default.
• W2057340929 cites W2002982210 @default.
• W2057340929 cites W2008957118 @default.
• W2057340929 cites W2014606320 @default.
• W2057340929 cites W2026255377 @default.
• W2057340929 cites W2027455260 @default.
• W2057340929 cites W2030951629 @default.
• W2057340929 cites W2051541780 @default.
• W2057340929 cites W2055096484 @default.
• W2057340929 cites W2060181803 @default.
• W2057340929 cites W2060842569 @default.
• W2057340929 cites W2060845434 @default.
• W2057340929 cites W2061560627 @default.
• W2057340929 cites W2065776802 @default.
• W2057340929 cites W2067286145 @default.
• W2057340929 cites W2090808827 @default.
• W2057340929 cites W2097065948 @default.
• W2057340929 cites W2102606027 @default.
• W2057340929 cites W2102619694 @default.
• W2057340929 cites W2103336924 @default.
• W2057340929 cites W2107916366 @default.
• W2057340929 cites W2112409097 @default.
• W2057340929 cites W2113532105 @default.
• W2057340929 cites W2116166762 @default.
• W2057340929 cites W2118308505 @default.
• W2057340929 cites W2118834857 @default.
• W2057340929 cites W2124084192 @default.
• W2057340929 cites W2124985265 @default.
• W2057340929 cites W2136309995 @default.
• W2057340929 cites W2136780715 @default.
• W2057340929 cites W2149548143 @default.
• W2057340929 cites W2151562469 @default.
• W2057340929 cites W2157115023 @default.
• W2057340929 cites W2159091439 @default.
• W2057340929 cites W2169986196 @default.
• W2057340929 cites W2171777347 @default.
• W2057340929 cites W2172052253 @default.
• W2057340929 doi "https://doi.org/10.1371/journal.pgen.1003594" @default.
• W2057340929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3770784" @default.
• W2057340929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23818875" @default.
• W2057340929 hasPublicationYear "2013" @default.
• W2057340929 type Work @default.
• W2057340929 sameAs 2057340929 @default.
• W2057340929 citedByCount "38" @default.
• W2057340929 countsByYear W20573409292013 @default.
• W2057340929 countsByYear W20573409292014 @default.
• W2057340929 countsByYear W20573409292015 @default.
• W2057340929 countsByYear W20573409292016 @default.
• W2057340929 countsByYear W20573409292017 @default.
• W2057340929 countsByYear W20573409292018 @default.
• W2057340929 countsByYear W20573409292019 @default.
• W2057340929 countsByYear W20573409292020 @default.
• W2057340929 countsByYear W20573409292021 @default.
• W2057340929 countsByYear W20573409292022 @default.
• W2057340929 crossrefType "journal-article" @default.
• W2057340929 hasAuthorship W2057340929A5006321682 @default.
• W2057340929 hasAuthorship W2057340929A5008602701 @default.
• W2057340929 hasAuthorship W2057340929A5008955525 @default.
• W2057340929 hasAuthorship W2057340929A5019130914 @default.
• W2057340929 hasAuthorship W2057340929A5026121576 @default.
• W2057340929 hasAuthorship W2057340929A5029024758 @default.
• W2057340929 hasAuthorship W2057340929A5035504682 @default.
• W2057340929 hasAuthorship W2057340929A5038334172 @default.
• W2057340929 hasAuthorship W2057340929A5040120668 @default.
• W2057340929 hasAuthorship W2057340929A5042714049 @default.
• W2057340929 hasAuthorship W2057340929A5047168944 @default.

• next