FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057352224> ?p ?o ?g. }

• W2057352224 endingPage "377" @default.
• W2057352224 startingPage "371" @default.
• W2057352224 abstract "Genes in the HLA complex are by far the most important in determining genetic predisposition or resistance to Type 1 (insulin-dependent) diabetes mellitus. In this review evidence is presented that the HLA genes mainly involved are those encoding some particular HLA-DQ molecules. Both among Black, Caucasian and Japanese subjects particular cis or trans encoded DQ molecules are significantly associated with susceptibility, while others are associated with resistance. A varying degree of susceptibility or resistance seems to be conferred by these DQ molecules, where those determining resistance are dominant over those determining susceptibility. The degree of genetic predisposition to develop Type 1 diabetes carried by an individual would therefore be the result of his or her particular combination of DQ molecules. A primary association to particular DQ molecules explains previously found associations to other HLA complex genes by linkage disequilibrium. Some mechanisms by which particular DQ molecules may determine susceptibility or resistance are also discussed. Potential islet beta-cell reactive CD4+ T-cells may escape negative selection (deletion) in the thymus, but normally become anergized or remain ignorant extra-thymically. However, under particular circumstances they may be triggered. The DQ molecules associated with Type 1 diabetes susceptibility may preferentially bind and present triggering and/or beta-cell derived peptides to such T cells, causing beta-cell destruction. The finding that particular DQ molecules determine susceptibility may lead to new methods of preventing development of Type 1 diabetes in susceptible individuals." @default.
• W2057352224 created "2016-06-24" @default.
• W2057352224 creator A5008943002 @default.
• W2057352224 creator A5036154593 @default.
• W2057352224 date "1993-05-01" @default.
• W2057352224 modified "2023-10-02" @default.
• W2057352224 title "Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to Type 1 (insulin-dependent) diabetes mellitus" @default.
• W2057352224 cites W142855006 @default.
• W2057352224 cites W1491849748 @default.
• W2057352224 cites W1554746088 @default.
• W2057352224 cites W1976866100 @default.
• W2057352224 cites W1978816002 @default.
• W2057352224 cites W1982205284 @default.
• W2057352224 cites W1986854804 @default.
• W2057352224 cites W1994425461 @default.
• W2057352224 cites W1995572182 @default.
• W2057352224 cites W2004319046 @default.
• W2057352224 cites W2008858451 @default.
• W2057352224 cites W2032358441 @default.
• W2057352224 cites W2037626742 @default.
• W2057352224 cites W2037919740 @default.
• W2057352224 cites W2043367286 @default.
• W2057352224 cites W2049884195 @default.
• W2057352224 cites W2056191911 @default.
• W2057352224 cites W2070721279 @default.
• W2057352224 cites W2079490247 @default.
• W2057352224 cites W2083009935 @default.
• W2057352224 cites W2083478840 @default.
• W2057352224 cites W2088227163 @default.
• W2057352224 cites W2089965324 @default.
• W2057352224 cites W2090046118 @default.
• W2057352224 cites W2092245783 @default.
• W2057352224 cites W2098129465 @default.
• W2057352224 cites W2099000356 @default.
• W2057352224 cites W2105423805 @default.
• W2057352224 cites W2111441225 @default.
• W2057352224 cites W2119763855 @default.
• W2057352224 cites W2121202724 @default.
• W2057352224 cites W2122085345 @default.
• W2057352224 cites W2124100144 @default.
• W2057352224 cites W2137136842 @default.
• W2057352224 cites W2137408395 @default.
• W2057352224 cites W2142153046 @default.
• W2057352224 cites W2146816378 @default.
• W2057352224 cites W2166099695 @default.
• W2057352224 cites W2316713837 @default.
• W2057352224 cites W2319802323 @default.
• W2057352224 cites W2336106483 @default.
• W2057352224 cites W2416821939 @default.
• W2057352224 cites W2443214182 @default.
• W2057352224 cites W2784027154 @default.
• W2057352224 cites W4211098139 @default.
• W2057352224 cites W4376849554 @default.
• W2057352224 doi "https://doi.org/10.1007/bf00402270" @default.
• W2057352224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8314439" @default.
• W2057352224 hasPublicationYear "1993" @default.
• W2057352224 type Work @default.
• W2057352224 sameAs 2057352224 @default.
• W2057352224 citedByCount "200" @default.
• W2057352224 countsByYear W20573522242012 @default.
• W2057352224 countsByYear W20573522242013 @default.
• W2057352224 countsByYear W20573522242014 @default.
• W2057352224 countsByYear W20573522242015 @default.
• W2057352224 countsByYear W20573522242019 @default.
• W2057352224 countsByYear W20573522242021 @default.
• W2057352224 countsByYear W20573522242022 @default.
• W2057352224 countsByYear W20573522242023 @default.
• W2057352224 crossrefType "journal-article" @default.
• W2057352224 hasAuthorship W2057352224A5008943002 @default.
• W2057352224 hasAuthorship W2057352224A5036154593 @default.
• W2057352224 hasBestOaLocation W20573522241 @default.
• W2057352224 hasConcept C104317684 @default.
• W2057352224 hasConcept C134018914 @default.
• W2057352224 hasConcept C147483822 @default.
• W2057352224 hasConcept C180754005 @default.
• W2057352224 hasConcept C188280979 @default.
• W2057352224 hasConcept C197754878 @default.
• W2057352224 hasConcept C203014093 @default.
• W2057352224 hasConcept C2777391703 @default.
• W2057352224 hasConcept C2779910283 @default.
• W2057352224 hasConcept C35605836 @default.
• W2057352224 hasConcept C54355233 @default.
• W2057352224 hasConcept C555293320 @default.
• W2057352224 hasConcept C67636389 @default.
• W2057352224 hasConcept C86803240 @default.
• W2057352224 hasConceptScore W2057352224C104317684 @default.
• W2057352224 hasConceptScore W2057352224C134018914 @default.
• W2057352224 hasConceptScore W2057352224C147483822 @default.
• W2057352224 hasConceptScore W2057352224C180754005 @default.
• W2057352224 hasConceptScore W2057352224C188280979 @default.
• W2057352224 hasConceptScore W2057352224C197754878 @default.
• W2057352224 hasConceptScore W2057352224C203014093 @default.
• W2057352224 hasConceptScore W2057352224C2777391703 @default.
• W2057352224 hasConceptScore W2057352224C2779910283 @default.
• W2057352224 hasConceptScore W2057352224C35605836 @default.
• W2057352224 hasConceptScore W2057352224C54355233 @default.
• W2057352224 hasConceptScore W2057352224C555293320 @default.
• W2057352224 hasConceptScore W2057352224C67636389 @default.

• next