Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057354910> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2057354910 endingPage "1628" @default.
- W2057354910 startingPage "1627" @default.
- W2057354910 abstract "The endothelins represent a family of three (ET-1, ET-2, and ET-3) isopeptides that are derived from vascular endothelial cells and function as potent vasoconstrictors 8, 11, 16. Two endothelin receptor subtypes, ETA and ETB, have been cloned and are structurally similar to the large family of guanine nucleotide-binding protein (G-protein) linked receptors 2, 13, 14. The ET receptor subtypes can also be distinguished by their different pharmacological profiles 6, 11. A novel linear peptide fragment of endothelin-1 (ET-1), N-acetyl-[Ala11,15]ET-1[6–21] (BQ3020) has been identified as a potent and ETB-selective agonist 7, 10, 12. [125I]BQ3020 binds with high affinity (Kd=31 pM) and limited capacity (Bmax=570 fmol/mg protein) to a single class of recognition sites in rat cerebellum [9]. High affinity [125I]BQ3020 binding is reduced in the presence of guanine nucleotides indicating an interaction with high and low affinity states of the ETB receptor [9]. This protocol describes the use of [125I]BQ3020 as a specific radioligand for the ETB receptor." @default.
- W2057354910 created "2016-06-24" @default.
- W2057354910 creator A5030154274 @default.
- W2057354910 creator A5090666536 @default.
- W2057354910 date "1990-07-01" @default.
- W2057354910 modified "2023-09-25" @default.
- W2057354910 title "Haemodynamic effects of NG-monomethyl-L-arginine (L-NMMA) in anaesthetized, spontaneously hypertensive (SH) rats: comparison with normotensive wistar-kyoto (WKY) controls" @default.
- W2057354910 cites W2153889396 @default.
- W2057354910 doi "https://doi.org/10.1016/0014-2999(90)91914-w" @default.
- W2057354910 hasPublicationYear "1990" @default.
- W2057354910 type Work @default.
- W2057354910 sameAs 2057354910 @default.
- W2057354910 citedByCount "1" @default.
- W2057354910 crossrefType "journal-article" @default.
- W2057354910 hasAuthorship W2057354910A5030154274 @default.
- W2057354910 hasAuthorship W2057354910A5090666536 @default.
- W2057354910 hasConcept C104317684 @default.
- W2057354910 hasConcept C126322002 @default.
- W2057354910 hasConcept C134018914 @default.
- W2057354910 hasConcept C144980905 @default.
- W2057354910 hasConcept C149601957 @default.
- W2057354910 hasConcept C170493617 @default.
- W2057354910 hasConcept C185592680 @default.
- W2057354910 hasConcept C2778301229 @default.
- W2057354910 hasConcept C2778938600 @default.
- W2057354910 hasConcept C2909649922 @default.
- W2057354910 hasConcept C2911175447 @default.
- W2057354910 hasConcept C512185932 @default.
- W2057354910 hasConcept C55493867 @default.
- W2057354910 hasConcept C67847695 @default.
- W2057354910 hasConcept C71924100 @default.
- W2057354910 hasConcept C80631254 @default.
- W2057354910 hasConcept C86803240 @default.
- W2057354910 hasConceptScore W2057354910C104317684 @default.
- W2057354910 hasConceptScore W2057354910C126322002 @default.
- W2057354910 hasConceptScore W2057354910C134018914 @default.
- W2057354910 hasConceptScore W2057354910C144980905 @default.
- W2057354910 hasConceptScore W2057354910C149601957 @default.
- W2057354910 hasConceptScore W2057354910C170493617 @default.
- W2057354910 hasConceptScore W2057354910C185592680 @default.
- W2057354910 hasConceptScore W2057354910C2778301229 @default.
- W2057354910 hasConceptScore W2057354910C2778938600 @default.
- W2057354910 hasConceptScore W2057354910C2909649922 @default.
- W2057354910 hasConceptScore W2057354910C2911175447 @default.
- W2057354910 hasConceptScore W2057354910C512185932 @default.
- W2057354910 hasConceptScore W2057354910C55493867 @default.
- W2057354910 hasConceptScore W2057354910C67847695 @default.
- W2057354910 hasConceptScore W2057354910C71924100 @default.
- W2057354910 hasConceptScore W2057354910C80631254 @default.
- W2057354910 hasConceptScore W2057354910C86803240 @default.
- W2057354910 hasIssue "5" @default.
- W2057354910 hasLocation W20573549101 @default.
- W2057354910 hasOpenAccess W2057354910 @default.
- W2057354910 hasPrimaryLocation W20573549101 @default.
- W2057354910 hasRelatedWork W1601021783 @default.
- W2057354910 hasRelatedWork W1983371938 @default.
- W2057354910 hasRelatedWork W1993143965 @default.
- W2057354910 hasRelatedWork W1996395961 @default.
- W2057354910 hasRelatedWork W2082137867 @default.
- W2057354910 hasRelatedWork W2094867358 @default.
- W2057354910 hasRelatedWork W2141307244 @default.
- W2057354910 hasRelatedWork W2160355439 @default.
- W2057354910 hasRelatedWork W2340893788 @default.
- W2057354910 hasRelatedWork W1938038024 @default.
- W2057354910 hasVolume "183" @default.
- W2057354910 isParatext "false" @default.
- W2057354910 isRetracted "false" @default.
- W2057354910 magId "2057354910" @default.
- W2057354910 workType "article" @default.