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- W2057368026 abstract "1. Summary of findings Recent studies of the anterior cingulate cortex in postmortem schizophrenic (SZ) brain have suggested that there may be several diAerent alterations in layer II of this region (ACCx-II). These include: (a) an increase in the density of vertical glutamatergic axons, (b) a decreased density of nonpyramidal neurons (NPs), (c) an upregulation of the GABAA receptor and (d) an increase of tyrosine hydroxylase-immunoreactive (TH-IR) varicosities in apposition with NPs. Taken together, these findings are consistent with a model in which a hyperinnervation of GABAergic cells by dopamine fibers occurs in ACCx-II of SZs. An excess amount of incoming excitatory activity from other cortical or subcortical regions that project to superficial laminae may also play a role in the generation of subtle structural and/or functional anomalies. The vertical axons that are increased in density in ACCx may originate in the basolateral nucleus (Bln) of the amygdala (AMYG) which is known to send a massive projection to layer II of this region." @default.
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- W2057368026 date "1999-11-01" @default.
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- W2057368026 title "Alterations of neural circuitry within layer II of anterior cingulate cortex in schizophrenia" @default.
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- W2057368026 doi "https://doi.org/10.1016/s0022-3956(99)00035-7" @default.
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