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• W2057371320 abstract "Vascular dysfunction contributes to the pathogenesis of various cardiovascular diseases. Dietary supplements, including fish oil, dietary fibers, and various natural products, and exercise training exert vasoprotective effects. However, the mechanisms underlying the vasoprotective benefits of dietary supplements and physical activity demand extensive investigation. Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNF α ) plays a pivotal role in the dysregulation of macrovascular and microvascular function. TNF α induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through multiple signaling pathways involving NF κ B, Sp1, activator protein 1, JNK, p38, STAT3, and so forth. Dietary supplements and exercise training decrease TNF α production and ameliorate TNF α -mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements and physical exercise on TNF α production and TNF α signaling may contribute to their vasoprotective properties." @default.
• W2057371320 created "2016-06-24" @default.
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• W2057371320 date "2012-01-01" @default.
• W2057371320 modified "2023-10-16" @default.
• W2057371320 title "Vasoprotection by Dietary Supplements and Exercise: Role of TNF<i>α</i>Signaling" @default.
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• W2057371320 doi "https://doi.org/10.1155/2012/972679" @default.
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