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• W2057373485 abstract "The aim of this study was to investigate the expression of caveolin-1 (Cav-1) in cancer-associated fibroblasts (CAFs) and to explore its correlation with clinicopathologic parameters and prognosis.Cav-1 expression was detected in the stroma of 143 patients with breast cancer, 10 patients with ductal carcinoma in situ (DCIS), and 10 normal breast tissue samples.Overexpression of stromal Cav-1 in breast cancer was associated with histological type, low histological grade, estrogen receptor (ER) negativity, and molecular subtypes. The expression rate of stromal Cav-1 in breast cancer (65.7%, 94/143) was significantly higher than that of DCIS (0%, 0/10) and normal breast tissue (0%, 0/10) (p = 0.000). A positive correlation was found between stromal Cav-1 and ER (p = 0.046, rs = 0.218). Stromal Cav-1 expression in luminal B was significantly higher than in basal-like type (p = 0.048). Furthermore, stromal expression of Cav-1 was significantly correlated with the 5-year survival rate (p = 0.029), and it was an independent prognostic factor (p = 0.009).Cav-1 expression in CAFs was correlated with histological type, histological grade, ER status, and molecular subtypes in breast cancer. Stromal Cav-1 expression was an independent prognostic factor, and the absence or reduction of Cav-1 expression in stromal CAFs of invasive breast cancer predicts poor prognostic outcome.Ziel dieser Studie war es, die Expression von Caveolin-1 (Cav-1) in karzinomassoziierten Fibroblasten (CAFs) und ihre Korrelation mit klinisch-pathologischen Parametern und Prognose zu untersuchen.Die Cav-1-Expression wurde im Stroma von 143 Mammakarzinompatientinnen, 10 Patientinnen mit duktalem Carcinoma in situ (DCIS) und 10 normalen Brustgewebeproben bestimmt.Überexpression von Cav-1 im Stroma von Mammakarzinomen war mit dem histologischen Typ, einem niedrigen histologischen Grad, Östrogenrezeptor (ER)-Negativität und molekularem Subtyp assoziiert. Die Expressionsrate von stromalem Cav-1 beim Mammakarzinom (65,7%, 94/143) war signifikant höher als beim DCIS (0%, 0/10) und im normalen Brustgewebe (0%, 0/10) (p = 0,000). Zwischen stromalem Cav-1 und ER bestand eine positive Korrelation (p = 0,046, rs = 0,218). Die Expression von stromalem Cav-1 im Luminal-B-Subtyp war signifikant höher als im Basal-like-Subtyp (p = 0,048). Desweiteren war die stromale Expression von Cav-1 signifikant mit dem 5-Jahresüberleben korreliert (p = 0,029) und wurde als ein unabhängiger Prognosefaktor identifiziert (p = 0,009).Die Cav-1-Expression in CAFs beim Mammakarzinom war mit dem histologischen Typ und Grad, dem ER-Status sowie dem molekularen Subtyp korreliert. Die stromale Cav-1-Expression war ein unabhängiger Prognosefaktor, und fehlende bzw. reduzierte Cav-1-Expression in stromalen CAFs beim invasiven Mammakarzinom ist indikativ für ein schlechtes Outcome." @default.
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• W2057373485 date "2012-01-01" @default.
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• W2057373485 title "Overexpression of Caveolin-1 in Cancer-Associated Fibroblasts Predicts Good Outcome in Breast Cancer" @default.
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• W2057373485 doi "https://doi.org/10.1159/000345464" @default.
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