Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057376073> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2057376073 abstract "Abstract The effects of 1 day of streptozotocin-induced diabetes in rats on glucose transport across the brush border membrane (BBM) and basolateral membrane (BLM) prepared from jejunal enterocytes has been studied. The effects on glucose transport of treatment of diabetic animals with insulin to reduce to normal the elevated blood glucose levels has also been assessed. The maximum capacity (V max ) for SGLT1-mediated glucose uptake by BBM vesicles was unaffected by diabetes or insulin treatment of diabetic rats. In contrast, V max for BLM glucose uptake was increased by 206% in diabetes, a response that could not be reversed by treatment with insulin. Western blotting of BBM for SGLT1 protein revealed a single band with a molecular weight of 73 kDa and the intensity of this band was unaffected by diabetes. However, an increased level of GLUT2 was noted in diabetic BLM and this was not a consequence of changes in glycaemic or insulin status. Diabetes hyperpolarised the BBM, implying an increased driving force for Na + -sugar co-transport but insulin treatment only partially reversed this enhanced potential difference. Benzamil (2 μ m ), an epithelial Na+ channel blocker, hyperpolarised the BBM of control but not diabetic enterocytes, implying that a reduced Na + permeability was responsible for the diabetic hyperpolarisation. It was concluded that in early diabetes, before the onset of hyperphagia, a greater driving force for Na + -dependent BBM sugar transport together with increased GLUT2 activity at the BLM promotes sugar movement across the enterocyte. Possible triggers for the transport responses are discussed. Journal of Endocrinology (1997) 154, 19–25" @default.
- W2057376073 created "2016-06-24" @default.
- W2057376073 creator A5008738366 @default.
- W2057376073 creator A5019923510 @default.
- W2057376073 creator A5030997667 @default.
- W2057376073 creator A5060916372 @default.
- W2057376073 creator A5083513543 @default.
- W2057376073 date "1997-07-01" @default.
- W2057376073 modified "2023-09-26" @default.
- W2057376073 title "Early diabetes-induced changes in rat jejunal glucose transport and the response to insulin" @default.
- W2057376073 doi "https://doi.org/10.1677/joe.0.1540019" @default.
- W2057376073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9246934" @default.
- W2057376073 hasPublicationYear "1997" @default.
- W2057376073 type Work @default.
- W2057376073 sameAs 2057376073 @default.
- W2057376073 citedByCount "8" @default.
- W2057376073 countsByYear W20573760732015 @default.
- W2057376073 countsByYear W20573760732022 @default.
- W2057376073 crossrefType "journal-article" @default.
- W2057376073 hasAuthorship W2057376073A5008738366 @default.
- W2057376073 hasAuthorship W2057376073A5019923510 @default.
- W2057376073 hasAuthorship W2057376073A5030997667 @default.
- W2057376073 hasAuthorship W2057376073A5060916372 @default.
- W2057376073 hasAuthorship W2057376073A5083513543 @default.
- W2057376073 hasConcept C126322002 @default.
- W2057376073 hasConcept C130316041 @default.
- W2057376073 hasConcept C134018914 @default.
- W2057376073 hasConcept C161573976 @default.
- W2057376073 hasConcept C185592680 @default.
- W2057376073 hasConcept C2777866211 @default.
- W2057376073 hasConcept C2777882243 @default.
- W2057376073 hasConcept C2777901630 @default.
- W2057376073 hasConcept C2779280383 @default.
- W2057376073 hasConcept C2779306644 @default.
- W2057376073 hasConcept C2779604457 @default.
- W2057376073 hasConcept C41625074 @default.
- W2057376073 hasConcept C5426402 @default.
- W2057376073 hasConcept C55493867 @default.
- W2057376073 hasConcept C555293320 @default.
- W2057376073 hasConcept C71924100 @default.
- W2057376073 hasConceptScore W2057376073C126322002 @default.
- W2057376073 hasConceptScore W2057376073C130316041 @default.
- W2057376073 hasConceptScore W2057376073C134018914 @default.
- W2057376073 hasConceptScore W2057376073C161573976 @default.
- W2057376073 hasConceptScore W2057376073C185592680 @default.
- W2057376073 hasConceptScore W2057376073C2777866211 @default.
- W2057376073 hasConceptScore W2057376073C2777882243 @default.
- W2057376073 hasConceptScore W2057376073C2777901630 @default.
- W2057376073 hasConceptScore W2057376073C2779280383 @default.
- W2057376073 hasConceptScore W2057376073C2779306644 @default.
- W2057376073 hasConceptScore W2057376073C2779604457 @default.
- W2057376073 hasConceptScore W2057376073C41625074 @default.
- W2057376073 hasConceptScore W2057376073C5426402 @default.
- W2057376073 hasConceptScore W2057376073C55493867 @default.
- W2057376073 hasConceptScore W2057376073C555293320 @default.
- W2057376073 hasConceptScore W2057376073C71924100 @default.
- W2057376073 hasLocation W20573760731 @default.
- W2057376073 hasLocation W20573760732 @default.
- W2057376073 hasOpenAccess W2057376073 @default.
- W2057376073 hasPrimaryLocation W20573760731 @default.
- W2057376073 hasRelatedWork W1970942296 @default.
- W2057376073 hasRelatedWork W1985743555 @default.
- W2057376073 hasRelatedWork W2004801687 @default.
- W2057376073 hasRelatedWork W2048770762 @default.
- W2057376073 hasRelatedWork W2057376073 @default.
- W2057376073 hasRelatedWork W2081915831 @default.
- W2057376073 hasRelatedWork W2140173719 @default.
- W2057376073 hasRelatedWork W2158234045 @default.
- W2057376073 hasRelatedWork W2170792291 @default.
- W2057376073 hasRelatedWork W2418538648 @default.
- W2057376073 isParatext "false" @default.
- W2057376073 isRetracted "false" @default.
- W2057376073 magId "2057376073" @default.
- W2057376073 workType "article" @default.