Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057377575> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2057377575 endingPage "312" @default.
- W2057377575 startingPage "309" @default.
- W2057377575 abstract "Several recent observations suggest that positive feedback may play a role in neurotrophic interactions between afferent basal forebrain cholinergic neurons and their cortical target neurons. NGF up-regulates the expression of its own receptors in these cholinergic neurons, and NGF and BDNF increase the production of the acetylcholine synthesizing enzyme, choline acetyltransferase. In a principle target area of these cholinergic neurons, the hippocampus, cholinergic activity up-regulates the expression of NGF and BDNF. Combination of these various effects could allow positive feedback interactions to develop between afferent and target neurons, such that neurons which compete successfully for trophic support become able to increase the production of trophic support available to them. Further investigations will be required to demonstrate the existence and importance of such a positive feedback interaction, but such interactions could provide novel insights into the role of neurotrophic interactions between afferent and target neurons in both normal function and disease. For example, initially small disturbances in access to trophic support might lead to a gradually spiralling decline in which neurons become progressively less functionally competent which in turn further reduces levels of available trophic support, culminating in progressive atrophy and degeneration." @default.
- W2057377575 created "2016-06-24" @default.
- W2057377575 creator A5009879178 @default.
- W2057377575 creator A5011858801 @default.
- W2057377575 date "1993-08-01" @default.
- W2057377575 modified "2023-09-27" @default.
- W2057377575 title "On the possibility of positive-feedback in trophic interactions between afferent and target neurons" @default.
- W2057377575 cites W1647925169 @default.
- W2057377575 cites W1816072488 @default.
- W2057377575 cites W1965129663 @default.
- W2057377575 cites W1980487073 @default.
- W2057377575 cites W1994721743 @default.
- W2057377575 cites W2013305718 @default.
- W2057377575 cites W2021280501 @default.
- W2057377575 cites W2025089255 @default.
- W2057377575 cites W2027795892 @default.
- W2057377575 cites W2027988197 @default.
- W2057377575 cites W2034258686 @default.
- W2057377575 cites W2039943037 @default.
- W2057377575 cites W2041789591 @default.
- W2057377575 cites W2042759696 @default.
- W2057377575 cites W2052850418 @default.
- W2057377575 cites W2055979394 @default.
- W2057377575 cites W2058199689 @default.
- W2057377575 cites W2060907356 @default.
- W2057377575 cites W2063050981 @default.
- W2057377575 cites W2076193941 @default.
- W2057377575 cites W2090592798 @default.
- W2057377575 cites W2092176884 @default.
- W2057377575 cites W2092683047 @default.
- W2057377575 cites W2409335393 @default.
- W2057377575 cites W2081246312 @default.
- W2057377575 doi "https://doi.org/10.1016/s1044-5765(05)80036-3" @default.
- W2057377575 hasPublicationYear "1993" @default.
- W2057377575 type Work @default.
- W2057377575 sameAs 2057377575 @default.
- W2057377575 citedByCount "6" @default.
- W2057377575 crossrefType "journal-article" @default.
- W2057377575 hasAuthorship W2057377575A5009879178 @default.
- W2057377575 hasAuthorship W2057377575A5011858801 @default.
- W2057377575 hasConcept C104966671 @default.
- W2057377575 hasConcept C160539049 @default.
- W2057377575 hasConcept C169760540 @default.
- W2057377575 hasConcept C170493617 @default.
- W2057377575 hasConcept C198399640 @default.
- W2057377575 hasConcept C22885893 @default.
- W2057377575 hasConcept C2776287375 @default.
- W2057377575 hasConcept C2778423431 @default.
- W2057377575 hasConcept C2781161787 @default.
- W2057377575 hasConcept C55493867 @default.
- W2057377575 hasConcept C86803240 @default.
- W2057377575 hasConcept C92020748 @default.
- W2057377575 hasConceptScore W2057377575C104966671 @default.
- W2057377575 hasConceptScore W2057377575C160539049 @default.
- W2057377575 hasConceptScore W2057377575C169760540 @default.
- W2057377575 hasConceptScore W2057377575C170493617 @default.
- W2057377575 hasConceptScore W2057377575C198399640 @default.
- W2057377575 hasConceptScore W2057377575C22885893 @default.
- W2057377575 hasConceptScore W2057377575C2776287375 @default.
- W2057377575 hasConceptScore W2057377575C2778423431 @default.
- W2057377575 hasConceptScore W2057377575C2781161787 @default.
- W2057377575 hasConceptScore W2057377575C55493867 @default.
- W2057377575 hasConceptScore W2057377575C86803240 @default.
- W2057377575 hasConceptScore W2057377575C92020748 @default.
- W2057377575 hasIssue "4" @default.
- W2057377575 hasLocation W20573775751 @default.
- W2057377575 hasOpenAccess W2057377575 @default.
- W2057377575 hasPrimaryLocation W20573775751 @default.
- W2057377575 hasRelatedWork W1192140695 @default.
- W2057377575 hasRelatedWork W1965912928 @default.
- W2057377575 hasRelatedWork W1967761338 @default.
- W2057377575 hasRelatedWork W1970017552 @default.
- W2057377575 hasRelatedWork W1996760996 @default.
- W2057377575 hasRelatedWork W2058304569 @default.
- W2057377575 hasRelatedWork W2069852703 @default.
- W2057377575 hasRelatedWork W2084861924 @default.
- W2057377575 hasRelatedWork W2088479689 @default.
- W2057377575 hasRelatedWork W2114907654 @default.
- W2057377575 hasVolume "5" @default.
- W2057377575 isParatext "false" @default.
- W2057377575 isRetracted "false" @default.
- W2057377575 magId "2057377575" @default.
- W2057377575 workType "article" @default.