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- W2057379898 abstract "Treatment of N-phenyl-iododifluoroacetamide (1) with terminal alkenes (2) in the presence of Na2S2O4 and NaHCO3 in CH3CN/H2O gave good yields of N-phenyl-2,2-difluoro-4-iodoalkanamide (3), which cyclized under strong basic conditions to afford N-phenyl-α,α-difluoro-γ-lactams (4). Or simply, these lactams 4 can be directly prepared in one-pot from 1 and 2 in the presence of Na2S2O4 and NaOH." @default.
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- W2057379898 date "2012-01-01" @default.
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- W2057379898 title "Rational and practical synthesis of α,α-difluoro-γ-lactams" @default.
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- W2057379898 doi "https://doi.org/10.1016/j.jfluchem.2011.10.013" @default.
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