Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057382689> ?p ?o ?g. }
- W2057382689 endingPage "285" @default.
- W2057382689 startingPage "275" @default.
- W2057382689 abstract "Acute heart failure (AHF) is characterized by high morbidity and mortality and high costs. Although the treatment of AHF has not changed substantially in recent decades, it is becoming clear that treatment strategies for AHF need to address both the immediate hemodynamic abnormalities giving rise to congestion as well as prevent organ damage that can influence long-term prognosis. Serelaxin, the recombinant form of human relaxin-2, a naturally occurring peptide hormone, has been found to significantly improve symptoms and signs of AHF, prevent in-hospital worsening heart failure, as well as significantly improve 180-day cardiovascular and all-cause mortality after a 48-h infusion commenced within 16 h of presentation (RELAX-AHF study). Available data suggest that the clinical benefits may be attributable to a potential combination of multiple actions of serelaxin, including improving systemic, cardiac, and renal hemodynamics, and protecting cells and organs from damage via anti-inflammatory, anti-cell death, anti-fibrotic, anti-hypertrophic, and pro-angiogenic effects. This manuscript describes the short- and long-term effects of serelaxin in AHF patients, analyzing how these effects can be explained by taking into account the range of hemodynamic and non-hemodynamic actions of serelaxin. In addition, this paper also addresses several aspects related to the role of serelaxin in the therapy of AHF that remain to be clarified and warrant further investigation." @default.
- W2057382689 created "2016-06-24" @default.
- W2057382689 creator A5066609762 @default.
- W2057382689 date "2014-03-04" @default.
- W2057382689 modified "2023-10-07" @default.
- W2057382689 title "Serelaxin: A Novel Therapy for Acute Heart Failure with a Range of Hemodynamic and Non-Hemodynamic Actions" @default.
- W2057382689 cites W1495512620 @default.
- W2057382689 cites W1519148279 @default.
- W2057382689 cites W1598621102 @default.
- W2057382689 cites W1672966032 @default.
- W2057382689 cites W1855631616 @default.
- W2057382689 cites W1945904268 @default.
- W2057382689 cites W1965371986 @default.
- W2057382689 cites W1967348896 @default.
- W2057382689 cites W1975425984 @default.
- W2057382689 cites W1977089899 @default.
- W2057382689 cites W1978868043 @default.
- W2057382689 cites W1981758027 @default.
- W2057382689 cites W1984353641 @default.
- W2057382689 cites W1985428858 @default.
- W2057382689 cites W1988534177 @default.
- W2057382689 cites W1989036527 @default.
- W2057382689 cites W1993630991 @default.
- W2057382689 cites W1995158939 @default.
- W2057382689 cites W1997405052 @default.
- W2057382689 cites W2001391676 @default.
- W2057382689 cites W2012271024 @default.
- W2057382689 cites W2013316384 @default.
- W2057382689 cites W2015997696 @default.
- W2057382689 cites W2016059466 @default.
- W2057382689 cites W2017044085 @default.
- W2057382689 cites W2017646079 @default.
- W2057382689 cites W2018492901 @default.
- W2057382689 cites W2019525662 @default.
- W2057382689 cites W2024703048 @default.
- W2057382689 cites W2025803854 @default.
- W2057382689 cites W2026470245 @default.
- W2057382689 cites W2029159827 @default.
- W2057382689 cites W2030951934 @default.
- W2057382689 cites W2031167728 @default.
- W2057382689 cites W2031808714 @default.
- W2057382689 cites W2032430294 @default.
- W2057382689 cites W2033955551 @default.
- W2057382689 cites W2034774373 @default.
- W2057382689 cites W2036720483 @default.
- W2057382689 cites W2040200136 @default.
- W2057382689 cites W2042519430 @default.
- W2057382689 cites W2043831882 @default.
- W2057382689 cites W2045045118 @default.
- W2057382689 cites W2047495536 @default.
- W2057382689 cites W2050481558 @default.
- W2057382689 cites W2054183115 @default.
- W2057382689 cites W2058689909 @default.
- W2057382689 cites W2062633545 @default.
- W2057382689 cites W2071957250 @default.
- W2057382689 cites W2072731873 @default.
- W2057382689 cites W2075304099 @default.
- W2057382689 cites W2078472921 @default.
- W2057382689 cites W2078818919 @default.
- W2057382689 cites W2082370121 @default.
- W2057382689 cites W2085522770 @default.
- W2057382689 cites W2092085317 @default.
- W2057382689 cites W2096133307 @default.
- W2057382689 cites W2097143107 @default.
- W2057382689 cites W2098083586 @default.
- W2057382689 cites W2099339447 @default.
- W2057382689 cites W2102172333 @default.
- W2057382689 cites W2104301000 @default.
- W2057382689 cites W2105095326 @default.
- W2057382689 cites W2105225153 @default.
- W2057382689 cites W2116132816 @default.
- W2057382689 cites W2117905676 @default.
- W2057382689 cites W2118292976 @default.
- W2057382689 cites W2118552848 @default.
- W2057382689 cites W2123336269 @default.
- W2057382689 cites W2123494220 @default.
- W2057382689 cites W2126420462 @default.
- W2057382689 cites W2126617656 @default.
- W2057382689 cites W2127057614 @default.
- W2057382689 cites W2132893424 @default.
- W2057382689 cites W2133739113 @default.
- W2057382689 cites W2136728517 @default.
- W2057382689 cites W2138742410 @default.
- W2057382689 cites W2139984622 @default.
- W2057382689 cites W2148841809 @default.
- W2057382689 cites W2149917671 @default.
- W2057382689 cites W2150784397 @default.
- W2057382689 cites W2151328457 @default.
- W2057382689 cites W2153889487 @default.
- W2057382689 cites W2154370947 @default.
- W2057382689 cites W2157115574 @default.
- W2057382689 cites W2160109802 @default.
- W2057382689 cites W2160489474 @default.
- W2057382689 cites W2164705414 @default.
- W2057382689 cites W2165742125 @default.
- W2057382689 cites W2181805087 @default.
- W2057382689 cites W2331858596 @default.
- W2057382689 cites W2406367964 @default.