Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057386289> ?p ?o ?g. }
- W2057386289 endingPage "1680" @default.
- W2057386289 startingPage "1675" @default.
- W2057386289 abstract "Abstract : Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent tissue repair program. During connective tissue repair, “activated” fibroblasts migrate into the wound area, where they synthesize and remodel newly created extracellular matrix. The specialized type of fibroblast responsible for this action is the α-smooth muscle actin (α-SMA)–expressing myofibroblast. Abnormal persistence of the myofibroblast is a hallmark of fibrotic diseases. Proteins such as transforming growth factor (TGF)β, endothelin-1, angiotensin II (Ang II), connective tissue growth factor (CCN2/CTGF), and platelet-derived growth factor (PDGF) appear to act in a network that contributes to myofibroblast differentiation and persistence. Drugs targeting these proteins are currently under consideration as antifibrotic treatments. This review summarizes recent observations concerning the contribution of TGFβ, endothelin-1, Ang II, CCN2, and PDGF and to fibroblast activation in tissue repair and fibrosis and the potential utility of agents blocking these proteins in affecting the outcome of cardiac fibrosis." @default.
- W2057386289 created "2016-06-24" @default.
- W2057386289 creator A5085867011 @default.
- W2057386289 date "2010-06-11" @default.
- W2057386289 modified "2023-10-16" @default.
- W2057386289 title "Potential Therapeutic Targets for Cardiac Fibrosis" @default.
- W2057386289 cites W1487581481 @default.
- W2057386289 cites W1505584712 @default.
- W2057386289 cites W1931924547 @default.
- W2057386289 cites W1963681955 @default.
- W2057386289 cites W1966100929 @default.
- W2057386289 cites W1967087287 @default.
- W2057386289 cites W1967227370 @default.
- W2057386289 cites W1972917598 @default.
- W2057386289 cites W1976162585 @default.
- W2057386289 cites W1983031935 @default.
- W2057386289 cites W1986698876 @default.
- W2057386289 cites W1993108215 @default.
- W2057386289 cites W1993929076 @default.
- W2057386289 cites W1994252128 @default.
- W2057386289 cites W2002999999 @default.
- W2057386289 cites W2005629438 @default.
- W2057386289 cites W2007175840 @default.
- W2057386289 cites W2010587847 @default.
- W2057386289 cites W2014244822 @default.
- W2057386289 cites W2029144169 @default.
- W2057386289 cites W2030619805 @default.
- W2057386289 cites W2037381436 @default.
- W2057386289 cites W2037749195 @default.
- W2057386289 cites W2042411282 @default.
- W2057386289 cites W2045282478 @default.
- W2057386289 cites W2051696368 @default.
- W2057386289 cites W2053837765 @default.
- W2057386289 cites W2057167681 @default.
- W2057386289 cites W2065407763 @default.
- W2057386289 cites W2067418860 @default.
- W2057386289 cites W2067754406 @default.
- W2057386289 cites W2071038507 @default.
- W2057386289 cites W2074225734 @default.
- W2057386289 cites W2078840238 @default.
- W2057386289 cites W2081557597 @default.
- W2057386289 cites W2086474709 @default.
- W2057386289 cites W2087027548 @default.
- W2057386289 cites W2087920840 @default.
- W2057386289 cites W2092441433 @default.
- W2057386289 cites W2094286678 @default.
- W2057386289 cites W2095946347 @default.
- W2057386289 cites W2099368049 @default.
- W2057386289 cites W2103031848 @default.
- W2057386289 cites W2105502622 @default.
- W2057386289 cites W2108806591 @default.
- W2057386289 cites W2110121929 @default.
- W2057386289 cites W2122808924 @default.
- W2057386289 cites W2122892151 @default.
- W2057386289 cites W2123179863 @default.
- W2057386289 cites W2124887937 @default.
- W2057386289 cites W2125736097 @default.
- W2057386289 cites W2127730885 @default.
- W2057386289 cites W2129280785 @default.
- W2057386289 cites W2132572082 @default.
- W2057386289 cites W2134024560 @default.
- W2057386289 cites W2138898099 @default.
- W2057386289 cites W2142070428 @default.
- W2057386289 cites W2142522073 @default.
- W2057386289 cites W2151079160 @default.
- W2057386289 cites W2153324184 @default.
- W2057386289 cites W2158987422 @default.
- W2057386289 cites W2163821775 @default.
- W2057386289 cites W2165209993 @default.
- W2057386289 cites W2169004918 @default.
- W2057386289 cites W4249341602 @default.
- W2057386289 doi "https://doi.org/10.1161/circresaha.110.217737" @default.
- W2057386289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20538689" @default.
- W2057386289 hasPublicationYear "2010" @default.
- W2057386289 type Work @default.
- W2057386289 sameAs 2057386289 @default.
- W2057386289 citedByCount "600" @default.
- W2057386289 countsByYear W20573862892012 @default.
- W2057386289 countsByYear W20573862892013 @default.
- W2057386289 countsByYear W20573862892014 @default.
- W2057386289 countsByYear W20573862892015 @default.
- W2057386289 countsByYear W20573862892016 @default.
- W2057386289 countsByYear W20573862892017 @default.
- W2057386289 countsByYear W20573862892018 @default.
- W2057386289 countsByYear W20573862892019 @default.
- W2057386289 countsByYear W20573862892020 @default.
- W2057386289 countsByYear W20573862892021 @default.
- W2057386289 countsByYear W20573862892022 @default.
- W2057386289 countsByYear W20573862892023 @default.
- W2057386289 crossrefType "journal-article" @default.
- W2057386289 hasAuthorship W2057386289A5085867011 @default.
- W2057386289 hasConcept C118131993 @default.
- W2057386289 hasConcept C126322002 @default.
- W2057386289 hasConcept C142724271 @default.
- W2057386289 hasConcept C170493617 @default.
- W2057386289 hasConcept C180361614 @default.
- W2057386289 hasConcept C189165786 @default.
- W2057386289 hasConcept C207865475 @default.