FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057387637> ?p ?o ?g. }

• W2057387637 endingPage "36" @default.
• W2057387637 startingPage "26" @default.
• W2057387637 abstract "Tumor necrosis factor-alpha (TNF-α) plays a central role in the pathogenesis of inflammatory bowel disease (IBD). Anti-TNF-α therapies have shown protective effects against colitis, but an efficient tool for target suppression of its secretion - ideally via oral administration - remains in urgent demand. In the colon tissue, TNF-α is mainly secreted by the colonic macrophages. Here, we report an orally-administrated microspheric vehicle that can target the colonic macrophages and suppress the local expression of TNF-α for IBD treatment. This vehicle is formed by cationic konjac glucomannan (cKGM), phytagel and an antisense oligonucleotide against TNF-α. It was given to dextran sodium sulfate (DSS) colitic mice via gastric perfusion. The unique swelling properties of cKGM enabled the spontaneous release of cKGM& antisense nucleotide (ASO) nano-complex from the phytagel scaffold into the colon lumen, where the ASO was transferred into colonic macrophages via receptor-mediated phagocytosis. The treatment significantly decreased the local level of TNF-α and alleviated the symptoms of colitis in the mice. In summary, our study demonstrates a convenient, orally-administrated drug delivery system that effectively targets colonic macrophages for suppression of TNF-α expression. It may represent a promising therapeutic approach in the treatment of IBD." @default.
• W2057387637 created "2016-06-24" @default.
• W2057387637 creator A5055985568 @default.
• W2057387637 creator A5057165108 @default.
• W2057387637 creator A5061361369 @default.
• W2057387637 creator A5064432881 @default.
• W2057387637 creator A5067937579 @default.
• W2057387637 creator A5074415258 @default.
• W2057387637 creator A5079512323 @default.
• W2057387637 creator A5083423037 @default.
• W2057387637 creator A5083881537 @default.
• W2057387637 creator A5030043887 @default.
• W2057387637 date "2015-04-01" @default.
• W2057387637 modified "2023-10-16" @default.
• W2057387637 title "An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease" @default.
• W2057387637 cites W1511118087 @default.
• W2057387637 cites W1768049875 @default.
• W2057387637 cites W1975088956 @default.
• W2057387637 cites W1983690361 @default.
• W2057387637 cites W1988357566 @default.
• W2057387637 cites W1992118657 @default.
• W2057387637 cites W1992529637 @default.
• W2057387637 cites W1993239608 @default.
• W2057387637 cites W1994720283 @default.
• W2057387637 cites W2002785080 @default.
• W2057387637 cites W2009943067 @default.
• W2057387637 cites W2030452459 @default.
• W2057387637 cites W2040488764 @default.
• W2057387637 cites W2047677325 @default.
• W2057387637 cites W2061502186 @default.
• W2057387637 cites W2062142897 @default.
• W2057387637 cites W2063418390 @default.
• W2057387637 cites W2071244487 @default.
• W2057387637 cites W2090581051 @default.
• W2057387637 cites W2104909111 @default.
• W2057387637 cites W2107531246 @default.
• W2057387637 cites W2125568721 @default.
• W2057387637 cites W2152429732 @default.
• W2057387637 cites W2159635467 @default.
• W2057387637 cites W2321453230 @default.
• W2057387637 cites W4244626580 @default.
• W2057387637 doi "https://doi.org/10.1016/j.biomaterials.2015.01.013" @default.
• W2057387637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25701029" @default.
• W2057387637 hasPublicationYear "2015" @default.
• W2057387637 type Work @default.
• W2057387637 sameAs 2057387637 @default.
• W2057387637 citedByCount "64" @default.
• W2057387637 countsByYear W20573876372015 @default.
• W2057387637 countsByYear W20573876372016 @default.
• W2057387637 countsByYear W20573876372017 @default.
• W2057387637 countsByYear W20573876372018 @default.
• W2057387637 countsByYear W20573876372019 @default.
• W2057387637 countsByYear W20573876372020 @default.
• W2057387637 countsByYear W20573876372021 @default.
• W2057387637 countsByYear W20573876372022 @default.
• W2057387637 countsByYear W20573876372023 @default.
• W2057387637 crossrefType "journal-article" @default.
• W2057387637 hasAuthorship W2057387637A5030043887 @default.
• W2057387637 hasAuthorship W2057387637A5055985568 @default.
• W2057387637 hasAuthorship W2057387637A5057165108 @default.
• W2057387637 hasAuthorship W2057387637A5061361369 @default.
• W2057387637 hasAuthorship W2057387637A5064432881 @default.
• W2057387637 hasAuthorship W2057387637A5067937579 @default.
• W2057387637 hasAuthorship W2057387637A5074415258 @default.
• W2057387637 hasAuthorship W2057387637A5079512323 @default.
• W2057387637 hasAuthorship W2057387637A5083423037 @default.
• W2057387637 hasAuthorship W2057387637A5083881537 @default.
• W2057387637 hasConcept C142724271 @default.
• W2057387637 hasConcept C17991360 @default.
• W2057387637 hasConcept C203014093 @default.
• W2057387637 hasConcept C2775862500 @default.
• W2057387637 hasConcept C2776914184 @default.
• W2057387637 hasConcept C2778260677 @default.
• W2057387637 hasConcept C2779134260 @default.
• W2057387637 hasConcept C2780479503 @default.
• W2057387637 hasConcept C2780942790 @default.
• W2057387637 hasConcept C502942594 @default.
• W2057387637 hasConcept C71924100 @default.
• W2057387637 hasConcept C98274493 @default.
• W2057387637 hasConceptScore W2057387637C142724271 @default.
• W2057387637 hasConceptScore W2057387637C17991360 @default.
• W2057387637 hasConceptScore W2057387637C203014093 @default.
• W2057387637 hasConceptScore W2057387637C2775862500 @default.
• W2057387637 hasConceptScore W2057387637C2776914184 @default.
• W2057387637 hasConceptScore W2057387637C2778260677 @default.
• W2057387637 hasConceptScore W2057387637C2779134260 @default.
• W2057387637 hasConceptScore W2057387637C2780479503 @default.
• W2057387637 hasConceptScore W2057387637C2780942790 @default.
• W2057387637 hasConceptScore W2057387637C502942594 @default.
• W2057387637 hasConceptScore W2057387637C71924100 @default.
• W2057387637 hasConceptScore W2057387637C98274493 @default.
• W2057387637 hasFunder F4320321001 @default.
• W2057387637 hasFunder F4320321106 @default.
• W2057387637 hasFunder F4320322841 @default.
• W2057387637 hasFunder F4320323893 @default.
• W2057387637 hasFunder F4320334924 @default.
• W2057387637 hasFunder F4320335471 @default.
• W2057387637 hasFunder F4320335777 @default.

• next