Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057389622> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2057389622 abstract "Abstract Mercaptopicolinic acid inhibited 14 CO 2 uptake and phosphoenolpyruvate carboxykinase activity in intact fluke. Studies with enzyme preparations showed that the inhibition was mixed-competitive with phosphoenolpyruvate and non-competitive with GTP. Inhibition was not reversed by Mn 2+ . Pyruvate kinase was not inhibited by mercaptopicolinic acid, although under certain circumstances, mercaptopicolinic acid interfered with the pyruvate kinase assay system. Intact flukes incubated with mercaptopicolinic acid showed depressed adenylate energy charge, increased lactic acid production and reduced flow of carbon from phosphoenolpyruvate to the mitochondrial substrate, malate. Additions of glutamate, alanine or aspartate did not reverse these effects even though, in each case, the amino acid was metabolised and considerably more acid end products were formed than in the absence of mercaptopicolinic acid. The changes in the concentrations of metabolites and end products are consistent with the view that, in flukes whose energy metabolism is impaired by mercaptopicolinic acid, pyruvate enters the mitochondrion and is converted to acetic and propionic acids." @default.
- W2057389622 created "2016-06-24" @default.
- W2057389622 creator A5005599222 @default.
- W2057389622 creator A5040306372 @default.
- W2057389622 date "1984-08-01" @default.
- W2057389622 modified "2023-09-26" @default.
- W2057389622 title "3-mercaptopicolinic acid and energy metabolism in the liver fluke, Fasciola hepatica" @default.
- W2057389622 cites W104465665 @default.
- W2057389622 cites W1538807883 @default.
- W2057389622 cites W1978492018 @default.
- W2057389622 cites W1979510095 @default.
- W2057389622 cites W1983458339 @default.
- W2057389622 cites W1997306864 @default.
- W2057389622 cites W2018222192 @default.
- W2057389622 cites W2020693612 @default.
- W2057389622 cites W2070504819 @default.
- W2057389622 cites W2075792127 @default.
- W2057389622 cites W2090895962 @default.
- W2057389622 cites W2104088449 @default.
- W2057389622 cites W2145762852 @default.
- W2057389622 cites W2300522002 @default.
- W2057389622 cites W2397861637 @default.
- W2057389622 cites W34540660 @default.
- W2057389622 doi "https://doi.org/10.1016/0020-7519(84)90093-6" @default.
- W2057389622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6469453" @default.
- W2057389622 hasPublicationYear "1984" @default.
- W2057389622 type Work @default.
- W2057389622 sameAs 2057389622 @default.
- W2057389622 citedByCount "4" @default.
- W2057389622 crossrefType "journal-article" @default.
- W2057389622 hasAuthorship W2057389622A5005599222 @default.
- W2057389622 hasAuthorship W2057389622A5040306372 @default.
- W2057389622 hasConcept C118716 @default.
- W2057389622 hasConcept C143937172 @default.
- W2057389622 hasConcept C165901193 @default.
- W2057389622 hasConcept C180526460 @default.
- W2057389622 hasConcept C181199279 @default.
- W2057389622 hasConcept C20251656 @default.
- W2057389622 hasConcept C20904676 @default.
- W2057389622 hasConcept C2775920511 @default.
- W2057389622 hasConcept C2777856171 @default.
- W2057389622 hasConcept C2779856020 @default.
- W2057389622 hasConcept C2780854706 @default.
- W2057389622 hasConcept C28859421 @default.
- W2057389622 hasConcept C3075310 @default.
- W2057389622 hasConcept C515207424 @default.
- W2057389622 hasConcept C523546767 @default.
- W2057389622 hasConcept C54355233 @default.
- W2057389622 hasConcept C55493867 @default.
- W2057389622 hasConcept C62231903 @default.
- W2057389622 hasConcept C86803240 @default.
- W2057389622 hasConcept C90856448 @default.
- W2057389622 hasConceptScore W2057389622C118716 @default.
- W2057389622 hasConceptScore W2057389622C143937172 @default.
- W2057389622 hasConceptScore W2057389622C165901193 @default.
- W2057389622 hasConceptScore W2057389622C180526460 @default.
- W2057389622 hasConceptScore W2057389622C181199279 @default.
- W2057389622 hasConceptScore W2057389622C20251656 @default.
- W2057389622 hasConceptScore W2057389622C20904676 @default.
- W2057389622 hasConceptScore W2057389622C2775920511 @default.
- W2057389622 hasConceptScore W2057389622C2777856171 @default.
- W2057389622 hasConceptScore W2057389622C2779856020 @default.
- W2057389622 hasConceptScore W2057389622C2780854706 @default.
- W2057389622 hasConceptScore W2057389622C28859421 @default.
- W2057389622 hasConceptScore W2057389622C3075310 @default.
- W2057389622 hasConceptScore W2057389622C515207424 @default.
- W2057389622 hasConceptScore W2057389622C523546767 @default.
- W2057389622 hasConceptScore W2057389622C54355233 @default.
- W2057389622 hasConceptScore W2057389622C55493867 @default.
- W2057389622 hasConceptScore W2057389622C62231903 @default.
- W2057389622 hasConceptScore W2057389622C86803240 @default.
- W2057389622 hasConceptScore W2057389622C90856448 @default.
- W2057389622 hasLocation W20573896221 @default.
- W2057389622 hasLocation W20573896222 @default.
- W2057389622 hasOpenAccess W2057389622 @default.
- W2057389622 hasPrimaryLocation W20573896221 @default.
- W2057389622 hasRelatedWork W1981641157 @default.
- W2057389622 hasRelatedWork W2031412667 @default.
- W2057389622 hasRelatedWork W2046651105 @default.
- W2057389622 hasRelatedWork W2046931968 @default.
- W2057389622 hasRelatedWork W2153627342 @default.
- W2057389622 hasRelatedWork W2165713701 @default.
- W2057389622 hasRelatedWork W2521213933 @default.
- W2057389622 hasRelatedWork W2672047022 @default.
- W2057389622 hasRelatedWork W2804007869 @default.
- W2057389622 hasRelatedWork W4241905898 @default.
- W2057389622 isParatext "false" @default.
- W2057389622 isRetracted "false" @default.
- W2057389622 magId "2057389622" @default.
- W2057389622 workType "article" @default.