FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057392690> ?p ?o ?g. }

• W2057392690 endingPage "369" @default.
• W2057392690 startingPage "365" @default.
• W2057392690 abstract "To compare the outcome of treatment of mediastinoscopy-verified N2 non-small-cell lung cancer treated with induction chemotherapy followed by either surgery or radiotherapy (RT), with both options followed by consolidation chemotherapy.A randomized Phase III trial for Stage IIIA (T1-T3N2M0) non-small cell lung cancer was conducted by the Radiation Therapy Oncology Group (RTOG) and Eastern Cooperative Oncology Group between April 1990 and April 1994. After documentation of N2 disease by mediastinoscopy or anterior mediastinotomy, patients received induction chemotherapy with cisplatin, vinblastine, and mitomycin-C. Mitomycin-C was later dropped from the induction regimen. Patients were then randomized to surgery or RT (64 Gy in 7 weeks) followed by cisplatin and vinblastine.RTOG 89-01 accrued 75 patients, of whom 73 were eligible and analyzable. Twelve patients received induction chemotherapy but were not randomized to RT or surgery thereafter. Forty-five patients were randomized to postinduction RT or surgery. Of the analyzable patients, 90% had a Karnofsky performance score of 90-100, 18% had weight loss >5%, 37% had squamous cell histologic features, and 54% had bulky N2 disease. The distribution of bulky N2 disease was uniform among the treatment arms. The incidence of Grade 4 toxicity was 56% in patients receiving mitomycin-C and 29% in those who did not. Only 1 patient in each group had acute nonhematologic toxicity greater than Grade 3 (nausea and vomiting). No acute Grade 4 radiation toxicity developed. The incidences of long-term toxicity were equivalent across the arms. Three treatment-related deaths occurred: 2 patients in the surgical arms (one late pulmonary toxicity and one pulmonary embolus), and 1 patient in the radiation arm (radiation pneumonitis). Induction chemotherapy was completed in 78% of the patients. Complete resection was performed in 73% of 26 patients undergoing thoracotomy. Consolidation chemotherapy was completed in 75% of the patients. No statistically significant difference was found among the treatment arms. The overall progression-free survival rate was 53% at 1 year and 17% at 3 years. The median progression-free survival was 14 months. No difference in the 1-year survival rate (70% vs. 66%) or median survival time (19.4 vs. 17.4 months) between the surgery and RT arms. The median survival in the patients receiving induction chemotherapy only was 8.9 months. Mitomycin-C had no impact on survival (p = 0.75). No statistically significant difference was noted in the time to local failure between the surgical and RT arms.The patient accrual to this trial made its results inconclusive, but several observations are notable. In this trial, histologic confirmation of N2 disease in the surgical and nonsurgical arms eliminated the usual biases from clinical staging. In this setting, local control and survival were essentially equal between the surgical and RT arms. The 3- and 5-year survival rates of nonsurgical therapy were comparable to published surgical trials of N2 disease." @default.
• W2057392690 created "2016-06-24" @default.
• W2057392690 creator A5008508128 @default.
• W2057392690 creator A5019357584 @default.
• W2057392690 creator A5030653008 @default.
• W2057392690 creator A5085643126 @default.
• W2057392690 date "2002-10-01" @default.
• W2057392690 modified "2023-09-24" @default.
• W2057392690 title "Phase III study comparing chemotherapy and radiotherapy with preoperative chemotherapy and surgical resection in patients with non-small-cell lung cancer with spread to mediastinal lymph nodes (N2); final report of RTOG 89-01" @default.
• W2057392690 cites W1817196311 @default.
• W2057392690 cites W1969375032 @default.
• W2057392690 cites W2040211532 @default.
• W2057392690 cites W2053018286 @default.
• W2057392690 cites W2072100134 @default.
• W2057392690 cites W2104325484 @default.
• W2057392690 cites W2108215214 @default.
• W2057392690 cites W2131928292 @default.
• W2057392690 cites W2226077283 @default.
• W2057392690 cites W4293241248 @default.
• W2057392690 cites W4293873735 @default.
• W2057392690 cites W4323238358 @default.
• W2057392690 doi "https://doi.org/10.1016/s0360-3016(02)02943-7" @default.
• W2057392690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12243809" @default.
• W2057392690 hasPublicationYear "2002" @default.
• W2057392690 type Work @default.
• W2057392690 sameAs 2057392690 @default.
• W2057392690 citedByCount "121" @default.
• W2057392690 countsByYear W20573926902012 @default.
• W2057392690 countsByYear W20573926902013 @default.
• W2057392690 countsByYear W20573926902014 @default.
• W2057392690 countsByYear W20573926902015 @default.
• W2057392690 countsByYear W20573926902016 @default.
• W2057392690 countsByYear W20573926902017 @default.
• W2057392690 countsByYear W20573926902018 @default.
• W2057392690 countsByYear W20573926902019 @default.
• W2057392690 countsByYear W20573926902020 @default.
• W2057392690 countsByYear W20573926902021 @default.
• W2057392690 countsByYear W20573926902022 @default.
• W2057392690 crossrefType "journal-article" @default.
• W2057392690 hasAuthorship W2057392690A5008508128 @default.
• W2057392690 hasAuthorship W2057392690A5019357584 @default.
• W2057392690 hasAuthorship W2057392690A5030653008 @default.
• W2057392690 hasAuthorship W2057392690A5085643126 @default.
• W2057392690 hasBestOaLocation W20573926901 @default.
• W2057392690 hasConcept C126322002 @default.
• W2057392690 hasConcept C141071460 @default.
• W2057392690 hasConcept C143998085 @default.
• W2057392690 hasConcept C2776256026 @default.
• W2057392690 hasConcept C2776611710 @default.
• W2057392690 hasConcept C2776694085 @default.
• W2057392690 hasConcept C2777132456 @default.
• W2057392690 hasConcept C2779338040 @default.
• W2057392690 hasConcept C2779961022 @default.
• W2057392690 hasConcept C2781413609 @default.
• W2057392690 hasConcept C509974204 @default.
• W2057392690 hasConcept C71924100 @default.
• W2057392690 hasConceptScore W2057392690C126322002 @default.
• W2057392690 hasConceptScore W2057392690C141071460 @default.
• W2057392690 hasConceptScore W2057392690C143998085 @default.
• W2057392690 hasConceptScore W2057392690C2776256026 @default.
• W2057392690 hasConceptScore W2057392690C2776611710 @default.
• W2057392690 hasConceptScore W2057392690C2776694085 @default.
• W2057392690 hasConceptScore W2057392690C2777132456 @default.
• W2057392690 hasConceptScore W2057392690C2779338040 @default.
• W2057392690 hasConceptScore W2057392690C2779961022 @default.
• W2057392690 hasConceptScore W2057392690C2781413609 @default.
• W2057392690 hasConceptScore W2057392690C509974204 @default.
• W2057392690 hasConceptScore W2057392690C71924100 @default.
• W2057392690 hasIssue "2" @default.
• W2057392690 hasLocation W20573926901 @default.
• W2057392690 hasLocation W20573926902 @default.
• W2057392690 hasOpenAccess W2057392690 @default.
• W2057392690 hasPrimaryLocation W20573926901 @default.
• W2057392690 hasRelatedWork W1956400930 @default.
• W2057392690 hasRelatedWork W2053018286 @default.
• W2057392690 hasRelatedWork W2084022711 @default.
• W2057392690 hasRelatedWork W2163567381 @default.
• W2057392690 hasRelatedWork W2357406576 @default.
• W2057392690 hasRelatedWork W2392262560 @default.
• W2057392690 hasRelatedWork W2417697013 @default.
• W2057392690 hasRelatedWork W2997709950 @default.
• W2057392690 hasRelatedWork W4382279650 @default.
• W2057392690 hasRelatedWork W1899415052 @default.
• W2057392690 hasVolume "54" @default.
• W2057392690 isParatext "false" @default.
• W2057392690 isRetracted "false" @default.
• W2057392690 magId "2057392690" @default.
• W2057392690 workType "article" @default.