Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057393174> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2057393174 abstract "Abstract To the Editor: In a recent paper we reported the synthesis and anticonvulsant properties of a series of new 2-substituted 3-aryl-4(3H)-quinazolinone analogues of 2 methyl-3-o-tolyl-4(3H)-quinazolinone (methaqualone). Preliminary screening of these compounds indicated that 4(3H)-quinazolinones ( 1 ) containing an isonicotinylmethyl group at the 2-position were the most effective in protecting against seizures induced by maximal electroshock (MES) or subcutaneous metrazol (scMet). Several compounds of this type were active in both the MES and scMet tests at doses of 100 mg/kg. In particular, two compounds ( 1 , R = CH 3 and Cl) showed good anticonvulsant activity and relatively low neurotoxicity after ip administration in mice." @default.
- W2057393174 created "2016-06-24" @default.
- W2057393174 creator A5055492279 @default.
- W2057393174 creator A5060388444 @default.
- W2057393174 creator A5088345503 @default.
- W2057393174 date "1991-07-01" @default.
- W2057393174 modified "2023-09-27" @default.
- W2057393174 title "Synthesis and Anticonvulsant Activity of Some New 3,6-Disubstituted-2-[2-oxo-2-(4-pyridyl)ethyl]-4(3H)-pyrimidinones" @default.
- W2057393174 cites W2058627275 @default.
- W2057393174 cites W2093022342 @default.
- W2057393174 cites W2125320282 @default.
- W2057393174 doi "https://doi.org/10.1002/jps.2600800719" @default.
- W2057393174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1941572" @default.
- W2057393174 hasPublicationYear "1991" @default.
- W2057393174 type Work @default.
- W2057393174 sameAs 2057393174 @default.
- W2057393174 citedByCount "3" @default.
- W2057393174 crossrefType "journal-article" @default.
- W2057393174 hasAuthorship W2057393174A5055492279 @default.
- W2057393174 hasAuthorship W2057393174A5060388444 @default.
- W2057393174 hasAuthorship W2057393174A5088345503 @default.
- W2057393174 hasConcept C118552586 @default.
- W2057393174 hasConcept C178790620 @default.
- W2057393174 hasConcept C185592680 @default.
- W2057393174 hasConcept C2775858608 @default.
- W2057393174 hasConcept C2776952961 @default.
- W2057393174 hasConcept C2777162773 @default.
- W2057393174 hasConcept C2778186239 @default.
- W2057393174 hasConcept C2779491297 @default.
- W2057393174 hasConcept C2909039623 @default.
- W2057393174 hasConcept C29730261 @default.
- W2057393174 hasConcept C43617362 @default.
- W2057393174 hasConcept C71240020 @default.
- W2057393174 hasConcept C71924100 @default.
- W2057393174 hasConcept C98274493 @default.
- W2057393174 hasConceptScore W2057393174C118552586 @default.
- W2057393174 hasConceptScore W2057393174C178790620 @default.
- W2057393174 hasConceptScore W2057393174C185592680 @default.
- W2057393174 hasConceptScore W2057393174C2775858608 @default.
- W2057393174 hasConceptScore W2057393174C2776952961 @default.
- W2057393174 hasConceptScore W2057393174C2777162773 @default.
- W2057393174 hasConceptScore W2057393174C2778186239 @default.
- W2057393174 hasConceptScore W2057393174C2779491297 @default.
- W2057393174 hasConceptScore W2057393174C2909039623 @default.
- W2057393174 hasConceptScore W2057393174C29730261 @default.
- W2057393174 hasConceptScore W2057393174C43617362 @default.
- W2057393174 hasConceptScore W2057393174C71240020 @default.
- W2057393174 hasConceptScore W2057393174C71924100 @default.
- W2057393174 hasConceptScore W2057393174C98274493 @default.
- W2057393174 hasLocation W20573931741 @default.
- W2057393174 hasLocation W20573931742 @default.
- W2057393174 hasOpenAccess W2057393174 @default.
- W2057393174 hasPrimaryLocation W20573931741 @default.
- W2057393174 hasRelatedWork W2005905138 @default.
- W2057393174 hasRelatedWork W2047237283 @default.
- W2057393174 hasRelatedWork W2057393174 @default.
- W2057393174 hasRelatedWork W2086582225 @default.
- W2057393174 hasRelatedWork W2093022342 @default.
- W2057393174 hasRelatedWork W2162760792 @default.
- W2057393174 hasRelatedWork W2186970651 @default.
- W2057393174 hasRelatedWork W2314351708 @default.
- W2057393174 hasRelatedWork W2533353513 @default.
- W2057393174 hasRelatedWork W2950759843 @default.
- W2057393174 isParatext "false" @default.
- W2057393174 isRetracted "false" @default.
- W2057393174 magId "2057393174" @default.
- W2057393174 workType "article" @default.