FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057395611> ?p ?o ?g. }

• W2057395611 endingPage "119" @default.
• W2057395611 startingPage "109" @default.
• W2057395611 abstract "As aberrant platelet activation underlies intra-arterial thrombus formation, dual antiplatelet therapy- of aspirin and clopidogrel- has become a mainstay of treatment of acute coronary thrombosis. Two complementary yet independent mechanisms of blocking platelet activation and aggregation have proven to be clinically beneficial in preventing atherothrombotic complications, including myocardial infarction (MI), stroke, cardiovascular (CV) death, as well as stent-associated thrombosis. Nonetheless, the combination of aspirin and clopidogrel has its drawbacks, and recurrent atherothrombotic events occur in patients receiving this dual antiplatelet therapy. Of note is the phenomenon of so-called resistance, also known as hyporesponsiveness, to aspirin and/or clopidogrel, as this predisposes to recurrent cardiovascular events. Other limitations of clopidogrel include its modest level platelet inhibition, a wide variability in patient response and delayed onset of action. Prasugrel, which is a new member of the thienopyridine antiplatelet agents, is able to overcome these shortcomings of clopidogrel. It is 10 times more potent, has a rapid onset, and is not as influenced by drug interactions nor genetic polymorphisms of cytochrome enzymes; thus prasugrel results in a faster, higher and more consistent level of platelet inhibition. Clinically this translates into a reduction in thrombo-occlusive events, but also an increased bleeding risk. This paper reviews the available pharmacological and clinical data on prasugrel and clarifies the current place of prasugrel in the management of arterial coronary thrombosis." @default.
• W2057395611 created "2016-06-24" @default.
• W2057395611 date "2010-01-01" @default.
• W2057395611 modified "2023-09-26" @default.
• W2057395611 title "Prasugrel: Review of its Role in the Management of Arterial Coronary Thrombosis" @default.
• W2057395611 cites W1553345686 @default.
• W2057395611 cites W1974238774 @default.
• W2057395611 cites W1985059672 @default.
• W2057395611 cites W1985835171 @default.
• W2057395611 cites W2003593234 @default.
• W2057395611 cites W2007108997 @default.
• W2057395611 cites W2015521606 @default.
• W2057395611 cites W2034514998 @default.
• W2057395611 cites W2057681387 @default.
• W2057395611 cites W2061975208 @default.
• W2057395611 cites W2069475893 @default.
• W2057395611 cites W2070419967 @default.
• W2057395611 cites W2076517423 @default.
• W2057395611 cites W2077194058 @default.
• W2057395611 cites W2081548185 @default.
• W2057395611 cites W2086599873 @default.
• W2057395611 cites W2088308053 @default.
• W2057395611 cites W2103481781 @default.
• W2057395611 cites W2103847217 @default.
• W2057395611 cites W2104599604 @default.
• W2057395611 cites W2105005467 @default.
• W2057395611 cites W2106415586 @default.
• W2057395611 cites W2110108344 @default.
• W2057395611 cites W2112494872 @default.
• W2057395611 cites W2116457054 @default.
• W2057395611 cites W2119951798 @default.
• W2057395611 cites W2122962595 @default.
• W2057395611 cites W2129001881 @default.
• W2057395611 cites W2130350603 @default.
• W2057395611 cites W2135319342 @default.
• W2057395611 cites W2135575592 @default.
• W2057395611 cites W2140220482 @default.
• W2057395611 cites W2142851865 @default.
• W2057395611 cites W2145126811 @default.
• W2057395611 cites W2147294426 @default.
• W2057395611 cites W2147746835 @default.
• W2057395611 cites W2148633205 @default.
• W2057395611 cites W2152823642 @default.
• W2057395611 cites W2156506897 @default.
• W2057395611 cites W2159858918 @default.
• W2057395611 cites W2168795101 @default.
• W2057395611 cites W2169387542 @default.
• W2057395611 cites W23524587 @default.
• W2057395611 cites W2945126509 @default.
• W2057395611 cites W2946689568 @default.
• W2057395611 cites W906589 @default.
• W2057395611 doi "https://doi.org/10.4137/cmrvh.s4678" @default.
• W2057395611 hasPublicationYear "2010" @default.
• W2057395611 type Work @default.
• W2057395611 sameAs 2057395611 @default.
• W2057395611 citedByCount "0" @default.
• W2057395611 crossrefType "journal-article" @default.
• W2057395611 hasConcept C126322002 @default.
• W2057395611 hasConcept C164705383 @default.
• W2057395611 hasConcept C2777028646 @default.
• W2057395611 hasConcept C2777698277 @default.
• W2057395611 hasConcept C2778976402 @default.
• W2057395611 hasConcept C2780868729 @default.
• W2057395611 hasConcept C500558357 @default.
• W2057395611 hasConcept C71924100 @default.
• W2057395611 hasConceptScore W2057395611C126322002 @default.
• W2057395611 hasConceptScore W2057395611C164705383 @default.
• W2057395611 hasConceptScore W2057395611C2777028646 @default.
• W2057395611 hasConceptScore W2057395611C2777698277 @default.
• W2057395611 hasConceptScore W2057395611C2778976402 @default.
• W2057395611 hasConceptScore W2057395611C2780868729 @default.
• W2057395611 hasConceptScore W2057395611C500558357 @default.
• W2057395611 hasConceptScore W2057395611C71924100 @default.
• W2057395611 hasLocation W20573956111 @default.
• W2057395611 hasOpenAccess W2057395611 @default.
• W2057395611 hasPrimaryLocation W20573956111 @default.
• W2057395611 hasRelatedWork W1961781761 @default.
• W2057395611 hasRelatedWork W1987110899 @default.
• W2057395611 hasRelatedWork W2021022223 @default.
• W2057395611 hasRelatedWork W2022049549 @default.
• W2057395611 hasRelatedWork W2043659752 @default.
• W2057395611 hasRelatedWork W2134981635 @default.
• W2057395611 hasRelatedWork W2170095119 @default.
• W2057395611 hasRelatedWork W2411409993 @default.
• W2057395611 hasRelatedWork W2464261172 @default.
• W2057395611 hasRelatedWork W2785044089 @default.
• W2057395611 hasVolume "2" @default.
• W2057395611 isParatext "false" @default.
• W2057395611 isRetracted "false" @default.
• W2057395611 magId "2057395611" @default.
• W2057395611 workType "article" @default.