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- W2057396913 endingPage "66" @default.
- W2057396913 startingPage "57" @default.
- W2057396913 abstract "Tolerance to self‐antigens within the adaptive immune system is safeguarded, at least in part, through deletion of autoreactive T and B lymphocytes. This deletion can occur during the development of these cells in primary lymphoid organs, the thymus or bone marrow, respectively, or at the mature stage in peripheral lymphoid tissues. Deletion of autoreactive lymphocytes is achieved to a large extent through apoptotic cell death. This review describes current understanding of the mechanisms that mediate apoptosis of autoreactive lymphocytes during their development in primary lymphoid organs and during their activation in the periphery. In particular, we discuss the roles of the proapoptotic Bcl‐2 family member Bim and the small family of Nur77‐related transcriptional regulators in lymphocyte negative selection. Finally, we speculate on the processes that may lead to the activation of Bim when antigen receptors are activated on autoreactive T or B cells." @default.
- W2057396913 created "2016-06-24" @default.
- W2057396913 creator A5011828915 @default.
- W2057396913 creator A5046532595 @default.
- W2057396913 creator A5055609597 @default.
- W2057396913 creator A5066769237 @default.
- W2057396913 date "2007-11-20" @default.
- W2057396913 modified "2023-09-26" @default.
- W2057396913 title "What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain" @default.
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