FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057402886> ?p ?o ?g. }

• W2057402886 endingPage "480" @default.
• W2057402886 startingPage "474" @default.
• W2057402886 abstract "Jolkinolide B (JB) and 17-hydroxy-JB (HJB) are diterpenoids from plants and it has been reported that the presence of a C-17 hydroxy group in JB significantly enhances the anti-inflammatory potency of JB. In this study, two HJB derivatives HJB-1 and HJB-2 were generated by the chemical modification of a 17-hydroxy group of HJB. HJB-1 more effectively inhibited TNF-α, IL-1β and IL-6 release in LPS-stimulated mouse peritoneal macrophages. In addition, HJB-1 reduced LPS-induced mRNA expression of TNF-α, IL-1β, IL-6, COX-2 and iNOS in a concentration-dependent manner, but did not alter IL-10 mRNA expression. LPS-induced NF-κB activation and MAPK phosphorylation were also effectively inhibited by HJB-1. These results demonstrate that HJB-1 exerts anti-inflammatory effects on LPS-activated mouse peritoneal macrophages by inhibiting NF-κB activation and MAPK phosphorylation and modification of a 17-hydroxy group of HJB may enhance the anti-inflammatory potency of HJB derivatives." @default.
• W2057402886 created "2016-06-24" @default.
• W2057402886 creator A5004389567 @default.
• W2057402886 creator A5010409371 @default.
• W2057402886 creator A5015082334 @default.
• W2057402886 creator A5042627512 @default.
• W2057402886 creator A5043176525 @default.
• W2057402886 creator A5045187929 @default.
• W2057402886 creator A5054311605 @default.
• W2057402886 creator A5056388603 @default.
• W2057402886 creator A5060239016 @default.
• W2057402886 creator A5083548222 @default.
• W2057402886 date "2014-08-01" @default.
• W2057402886 modified "2023-10-16" @default.
• W2057402886 title "HJB-1, a 17-hydroxy-jolkinolide B derivative, inhibits LPS-induced inflammation in mouse peritoneal macrophages" @default.
• W2057402886 cites W1980768491 @default.
• W2057402886 cites W1994858290 @default.
• W2057402886 cites W1998950814 @default.
• W2057402886 cites W2002145523 @default.
• W2057402886 cites W2002410294 @default.
• W2057402886 cites W2007469779 @default.
• W2057402886 cites W2019928890 @default.
• W2057402886 cites W2022025132 @default.
• W2057402886 cites W2022374442 @default.
• W2057402886 cites W2024303872 @default.
• W2057402886 cites W2036606290 @default.
• W2057402886 cites W2042433863 @default.
• W2057402886 cites W2058306389 @default.
• W2057402886 cites W2061196059 @default.
• W2057402886 cites W2062835892 @default.
• W2057402886 cites W2080366118 @default.
• W2057402886 cites W2081815828 @default.
• W2057402886 cites W2111117723 @default.
• W2057402886 cites W2118278569 @default.
• W2057402886 cites W2119691056 @default.
• W2057402886 cites W2133439754 @default.
• W2057402886 cites W2320841243 @default.
• W2057402886 cites W2335925695 @default.
• W2057402886 cites W2419100559 @default.
• W2057402886 cites W2766221641 @default.
• W2057402886 doi "https://doi.org/10.1016/j.intimp.2014.06.002" @default.
• W2057402886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24933588" @default.
• W2057402886 hasPublicationYear "2014" @default.
• W2057402886 type Work @default.
• W2057402886 sameAs 2057402886 @default.
• W2057402886 citedByCount "5" @default.
• W2057402886 countsByYear W20574028862015 @default.
• W2057402886 countsByYear W20574028862016 @default.
• W2057402886 countsByYear W20574028862017 @default.
• W2057402886 countsByYear W20574028862020 @default.
• W2057402886 crossrefType "journal-article" @default.
• W2057402886 hasAuthorship W2057402886A5004389567 @default.
• W2057402886 hasAuthorship W2057402886A5010409371 @default.
• W2057402886 hasAuthorship W2057402886A5015082334 @default.
• W2057402886 hasAuthorship W2057402886A5042627512 @default.
• W2057402886 hasAuthorship W2057402886A5043176525 @default.
• W2057402886 hasAuthorship W2057402886A5045187929 @default.
• W2057402886 hasAuthorship W2057402886A5054311605 @default.
• W2057402886 hasAuthorship W2057402886A5056388603 @default.
• W2057402886 hasAuthorship W2057402886A5060239016 @default.
• W2057402886 hasAuthorship W2057402886A5083548222 @default.
• W2057402886 hasConcept C11960822 @default.
• W2057402886 hasConcept C126255220 @default.
• W2057402886 hasConcept C126322002 @default.
• W2057402886 hasConcept C134018914 @default.
• W2057402886 hasConcept C17991360 @default.
• W2057402886 hasConcept C185592680 @default.
• W2057402886 hasConcept C196978813 @default.
• W2057402886 hasConcept C2776914184 @default.
• W2057402886 hasConcept C33923547 @default.
• W2057402886 hasConcept C55493867 @default.
• W2057402886 hasConcept C57074206 @default.
• W2057402886 hasConcept C71924100 @default.
• W2057402886 hasConcept C91575142 @default.
• W2057402886 hasConceptScore W2057402886C11960822 @default.
• W2057402886 hasConceptScore W2057402886C126255220 @default.
• W2057402886 hasConceptScore W2057402886C126322002 @default.
• W2057402886 hasConceptScore W2057402886C134018914 @default.
• W2057402886 hasConceptScore W2057402886C17991360 @default.
• W2057402886 hasConceptScore W2057402886C185592680 @default.
• W2057402886 hasConceptScore W2057402886C196978813 @default.
• W2057402886 hasConceptScore W2057402886C2776914184 @default.
• W2057402886 hasConceptScore W2057402886C33923547 @default.
• W2057402886 hasConceptScore W2057402886C55493867 @default.
• W2057402886 hasConceptScore W2057402886C57074206 @default.
• W2057402886 hasConceptScore W2057402886C71924100 @default.
• W2057402886 hasConceptScore W2057402886C91575142 @default.
• W2057402886 hasFunder F4320321001 @default.
• W2057402886 hasFunder F4320327282 @default.
• W2057402886 hasIssue "2" @default.
• W2057402886 hasLocation W20574028861 @default.
• W2057402886 hasLocation W20574028862 @default.
• W2057402886 hasOpenAccess W2057402886 @default.
• W2057402886 hasPrimaryLocation W20574028861 @default.
• W2057402886 hasRelatedWork W1966504330 @default.
• W2057402886 hasRelatedWork W1974041167 @default.
• W2057402886 hasRelatedWork W1977918131 @default.
• W2057402886 hasRelatedWork W1979139803 @default.

• next