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- W2057412056 abstract "A serum (Tö) from a patient with asymptotic Waldenström macroglobulinemia contained two γMκ M-components which differed from each other with respect to combining specificity, individual antigenic specificity and electrophoretic mobility. The predominant M-component precipitated with an acid polysaccharide from Klebsiella ozaenae and with an unidentified component of agar. The precipitation was completely inhibited by 0·0.4 M dinitrophenol, but the M-component did not precipitate with hemocyanine heavily conjugated with trinitrophenyl groups (TNP-HCy). By analytical ultracentrifugation, the Fab fragment of the γM molecule was found to contain the active site. The specificity of the reaction was high, since the M-component discriminated between two acid polysaccharides produced by a homogeneous bacterial type and failed to precipitate with many acid polysaccharides from various sources. The other M-component precipitated weakly with TNP-HCy but not with the bacterial polysaccharide or agar. Antisera against each M-component defined individually specific antigenic determinants, some of which were present on both M-components, while others were unique for each individual M-component. The individually specific determinants of the predominant M-component were located on the Fab fragments. The slight net charge difference between the M-components was also found on the Fab fragments." @default.
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- W2057412056 date "1970-11-01" @default.
- W2057412056 modified "2023-09-25" @default.
- W2057412056 title "Multiple M-components in a single individual—I" @default.
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- W2057412056 doi "https://doi.org/10.1016/0019-2791(70)90052-2" @default.
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