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- W2057419786 abstract "Fractions of varying molecular size and chemical composition were isolated from glomerular basement membrane (GBM) and characterized inimunochemically. Reduction and alkylation in 8 M urea results in a fraction (GRAU) with an amino acid and carbohydrate composition similar to the whole membrane. Antiserum to this fraction (anti-GRAU) gives two precipitin lines upon immunodiffusion. Reduction and alkylation in the absence of 8 M urea results in a fraction with significantly less hydroxyproline and hydroxylysine which gives two precipitin lines of identity with GRAU when reacted against anti-GRAU. One of these precipitin lines is given by a fraction which can be obtained either after extraction with 8 M urea or as the undigested residue after treatment of GBM with collagenase. This fraction has a molecular weight of over 200,000, has low amounts of hydroxyproline and hydroxylysine and a glucose to galactose ratio of 0.25. The second precipitin line is given by a smallmolecular weight glycoprotein which is retarded on Sephadex G-200 and is obtained after digestion of GBM with collagenase. This fraction lacks hydroxyproline and hydroxylysine and has a glucose to galactose ratio of 0.08. The collagen-like protein represents a third antigenic component; it can be obtained after limited digestion of GBM with pronase or pepsin. It has a glucose to galactose ratio of 0.95. It fails to give a precipitin line with anti-GlUU; however, it is antigenic and gives rise to precipitin antibodies in rabbits. Basement membranes from various tissues contain variable proportions of these antigenic components which are responsible for the cross-reaction seen among these extracellular matrices." @default.
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- W2057419786 date "1972-01-01" @default.
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- W2057419786 title "The Chemistry of Antigenic Components Isolated From Glomerular Basement Membrane" @default.
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- W2057419786 doi "https://doi.org/10.3109/03008207209152050" @default.
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