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- W2057420912 abstract "5-alkynyl tubercidin analogues were synthesized and their biological activities were evaluated. It was found that protein kinase A could be activated by 5-alkynyl tubercidin (9a) and cAMP-binding ability to PKA-I was selectively inhibited by it. Molecular modeling showed that the interaction of 9a and PKA-I was associated with the existence of hydrophobic alkynyl group. During the synthesis of tubercidin analogues, a pair of 2'-carbonyl participating abnormal coupling products (11a, 11b) was obtained, the structure was identified by X-ray crystalline diffraction." @default.
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- W2057420912 date "2002-04-01" @default.
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- W2057420912 title "Study on the Synthesis and PKA-I Binding Activities of 5-Alkynyl Tubercidin Analogues" @default.
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- W2057420912 doi "https://doi.org/10.1016/s0968-0896(01)00341-8" @default.
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