Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057423712> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2057423712 abstract "Studies were conducted to examine the contribution of adrenal 5alpha-reductase to the phenomenon of diminished adrenal responsiveness to ACTH after hypophysectomy in rats. Rats hypophysectomized for 1 week secreted small amounts of corticosterone (B), 5alpha-dihydrocorticosterone (DHB) and 3beta,5alpha-tetrahydrocorticosterone (R) acutely after ACTH. Adrenal reductase activity in vitro at that time was high. After replacement with ACTH for 24 h, B,DBH, and R secretion increased slightly. Reductase activity remained high. Treatment with ACTH for 2 days further stimulated secretion of DHB and R but not B. Reductase activity was unaffected. Enzyme activity declined at 3 days concomitant with a proportionately greater increase in B than DHB and R secretion. Only after 7 days of ACTH did B secretion exceed DHB and R output. At that time, reductase activity was still lower. The results establish the functional significance of 5alpha-reductase activity as a regulatory site for the action of ACTH in determining the composition of adrenocortical secretory products in hypophysectomized rats." @default.
- W2057423712 created "2016-06-24" @default.
- W2057423712 creator A5020757751 @default.
- W2057423712 creator A5031891304 @default.
- W2057423712 creator A5047885417 @default.
- W2057423712 creator A5073190711 @default.
- W2057423712 date "1975-05-01" @default.
- W2057423712 modified "2023-09-26" @default.
- W2057423712 title "Role of Adrenal 5a-Reductase Activity in Determining the Responsiveness of Hypophysectomized Rats to ACTH" @default.
- W2057423712 cites W632207332 @default.
- W2057423712 doi "https://doi.org/10.1210/endo-96-5-1153" @default.
- W2057423712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/164343" @default.
- W2057423712 hasPublicationYear "1975" @default.
- W2057423712 type Work @default.
- W2057423712 sameAs 2057423712 @default.
- W2057423712 citedByCount "13" @default.
- W2057423712 crossrefType "journal-article" @default.
- W2057423712 hasAuthorship W2057423712A5020757751 @default.
- W2057423712 hasAuthorship W2057423712A5031891304 @default.
- W2057423712 hasAuthorship W2057423712A5047885417 @default.
- W2057423712 hasAuthorship W2057423712A5073190711 @default.
- W2057423712 hasConcept C126322002 @default.
- W2057423712 hasConcept C134018914 @default.
- W2057423712 hasConcept C181199279 @default.
- W2057423712 hasConcept C185592680 @default.
- W2057423712 hasConcept C2780104272 @default.
- W2057423712 hasConcept C2780352252 @default.
- W2057423712 hasConcept C2780546910 @default.
- W2057423712 hasConcept C28212737 @default.
- W2057423712 hasConcept C2909643783 @default.
- W2057423712 hasConcept C49039625 @default.
- W2057423712 hasConcept C55493867 @default.
- W2057423712 hasConcept C71315377 @default.
- W2057423712 hasConcept C71924100 @default.
- W2057423712 hasConcept C86803240 @default.
- W2057423712 hasConceptScore W2057423712C126322002 @default.
- W2057423712 hasConceptScore W2057423712C134018914 @default.
- W2057423712 hasConceptScore W2057423712C181199279 @default.
- W2057423712 hasConceptScore W2057423712C185592680 @default.
- W2057423712 hasConceptScore W2057423712C2780104272 @default.
- W2057423712 hasConceptScore W2057423712C2780352252 @default.
- W2057423712 hasConceptScore W2057423712C2780546910 @default.
- W2057423712 hasConceptScore W2057423712C28212737 @default.
- W2057423712 hasConceptScore W2057423712C2909643783 @default.
- W2057423712 hasConceptScore W2057423712C49039625 @default.
- W2057423712 hasConceptScore W2057423712C55493867 @default.
- W2057423712 hasConceptScore W2057423712C71315377 @default.
- W2057423712 hasConceptScore W2057423712C71924100 @default.
- W2057423712 hasConceptScore W2057423712C86803240 @default.
- W2057423712 hasLocation W20574237121 @default.
- W2057423712 hasLocation W20574237122 @default.
- W2057423712 hasOpenAccess W2057423712 @default.
- W2057423712 hasPrimaryLocation W20574237121 @default.
- W2057423712 hasRelatedWork W1979702247 @default.
- W2057423712 hasRelatedWork W1991851414 @default.
- W2057423712 hasRelatedWork W2002320008 @default.
- W2057423712 hasRelatedWork W2033245480 @default.
- W2057423712 hasRelatedWork W2052434669 @default.
- W2057423712 hasRelatedWork W2067659929 @default.
- W2057423712 hasRelatedWork W2082031804 @default.
- W2057423712 hasRelatedWork W2103198803 @default.
- W2057423712 hasRelatedWork W2130367712 @default.
- W2057423712 hasRelatedWork W56439275 @default.
- W2057423712 isParatext "false" @default.
- W2057423712 isRetracted "false" @default.
- W2057423712 magId "2057423712" @default.
- W2057423712 workType "article" @default.