Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057433840> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2057433840 endingPage "215" @default.
- W2057433840 startingPage "211" @default.
- W2057433840 abstract "Neutrophils contain two renaturable p21-activated protein kinases (Paks) with molecular masses of ca. 69 and 63 kDa that undergo rapid activation upon stimulation of these cells with the chemoattractant fMet-Leu-Phe. We now report that these kinases undergo a massive, ATP-dependent activation in lysates of unstimulated neutrophils during immunoprecipitation with an antibody generated to residues 2-21 of the N-terminal region of Pak1. This activation was specific as it was completely blocked by a peptide that corresponds to residues 2-21 of Pak1 and was not observed with an antibody generated to the C-terminal region of Pak 1. The properties of the Paks activated with the antibody were virtually identical to those observed for these kinases from stimulated neutrophils, or activated in vitro with Rac-GTPgammaS plus ATP. These data indicate that perturbation of the N-terminal region of Pak can trigger activation of this enzyme, and that both the 69 and 63 kDa kinases may represent forms of Pak 1 that differ in their content of phosphate." @default.
- W2057433840 created "2016-06-24" @default.
- W2057433840 creator A5014684415 @default.
- W2057433840 creator A5024114565 @default.
- W2057433840 date "1997-03-10" @default.
- W2057433840 modified "2023-09-26" @default.
- W2057433840 title "Activation of the p21-activated protein kinases from neutrophils with an antibody that reacts with the N-terminal region of Pak 1" @default.
- W2057433840 cites W1196959594 @default.
- W2057433840 cites W1481746756 @default.
- W2057433840 cites W1498993468 @default.
- W2057433840 cites W1503573288 @default.
- W2057433840 cites W1510096420 @default.
- W2057433840 cites W1548377812 @default.
- W2057433840 cites W1555692789 @default.
- W2057433840 cites W1594845404 @default.
- W2057433840 cites W1595120221 @default.
- W2057433840 cites W1611906974 @default.
- W2057433840 cites W1662447390 @default.
- W2057433840 cites W1665730372 @default.
- W2057433840 cites W1941092842 @default.
- W2057433840 cites W1980148334 @default.
- W2057433840 cites W1986404782 @default.
- W2057433840 cites W1989987282 @default.
- W2057433840 cites W1992000164 @default.
- W2057433840 cites W2010234097 @default.
- W2057433840 cites W2011756230 @default.
- W2057433840 cites W2019753526 @default.
- W2057433840 cites W2021289405 @default.
- W2057433840 cites W2036123452 @default.
- W2057433840 cites W2041977269 @default.
- W2057433840 cites W2044368298 @default.
- W2057433840 cites W2047363555 @default.
- W2057433840 cites W2057069307 @default.
- W2057433840 cites W2064785971 @default.
- W2057433840 cites W2085950174 @default.
- W2057433840 doi "https://doi.org/10.1016/s0014-5793(97)00134-8" @default.
- W2057433840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9119066" @default.
- W2057433840 hasPublicationYear "1997" @default.
- W2057433840 type Work @default.
- W2057433840 sameAs 2057433840 @default.
- W2057433840 citedByCount "6" @default.
- W2057433840 countsByYear W20574338402014 @default.
- W2057433840 crossrefType "journal-article" @default.
- W2057433840 hasAuthorship W2057433840A5014684415 @default.
- W2057433840 hasAuthorship W2057433840A5024114565 @default.
- W2057433840 hasBestOaLocation W20574338401 @default.
- W2057433840 hasConcept C104317684 @default.
- W2057433840 hasConcept C11960822 @default.
- W2057433840 hasConcept C153911025 @default.
- W2057433840 hasConcept C159654299 @default.
- W2057433840 hasConcept C184235292 @default.
- W2057433840 hasConcept C185592680 @default.
- W2057433840 hasConcept C203014093 @default.
- W2057433840 hasConcept C24901178 @default.
- W2057433840 hasConcept C55493867 @default.
- W2057433840 hasConcept C71829478 @default.
- W2057433840 hasConcept C86803240 @default.
- W2057433840 hasConcept C95444343 @default.
- W2057433840 hasConceptScore W2057433840C104317684 @default.
- W2057433840 hasConceptScore W2057433840C11960822 @default.
- W2057433840 hasConceptScore W2057433840C153911025 @default.
- W2057433840 hasConceptScore W2057433840C159654299 @default.
- W2057433840 hasConceptScore W2057433840C184235292 @default.
- W2057433840 hasConceptScore W2057433840C185592680 @default.
- W2057433840 hasConceptScore W2057433840C203014093 @default.
- W2057433840 hasConceptScore W2057433840C24901178 @default.
- W2057433840 hasConceptScore W2057433840C55493867 @default.
- W2057433840 hasConceptScore W2057433840C71829478 @default.
- W2057433840 hasConceptScore W2057433840C86803240 @default.
- W2057433840 hasConceptScore W2057433840C95444343 @default.
- W2057433840 hasIssue "2-3" @default.
- W2057433840 hasLocation W20574338401 @default.
- W2057433840 hasLocation W20574338402 @default.
- W2057433840 hasOpenAccess W2057433840 @default.
- W2057433840 hasPrimaryLocation W20574338401 @default.
- W2057433840 hasRelatedWork W1831001883 @default.
- W2057433840 hasRelatedWork W1990341003 @default.
- W2057433840 hasRelatedWork W2029295729 @default.
- W2057433840 hasRelatedWork W2057967888 @default.
- W2057433840 hasRelatedWork W2065356248 @default.
- W2057433840 hasRelatedWork W2098882468 @default.
- W2057433840 hasRelatedWork W2110242189 @default.
- W2057433840 hasRelatedWork W2319033582 @default.
- W2057433840 hasRelatedWork W2805781019 @default.
- W2057433840 hasRelatedWork W2136545008 @default.
- W2057433840 hasVolume "404" @default.
- W2057433840 isParatext "false" @default.
- W2057433840 isRetracted "false" @default.
- W2057433840 magId "2057433840" @default.
- W2057433840 workType "article" @default.