FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057434505> ?p ?o ?g. }

• W2057434505 endingPage "338" @default.
• W2057434505 startingPage "334" @default.
• W2057434505 abstract "Numerous mechanisms relating to lipopolysaccharide- (LPS) induced gastroprotection have been proposed. The prostaglandin (PG) system is a promising candidate that has received considerable attention. However, the role of prostacyclin (PGI2) remains unclear. Adult, male Sprague-Dawley rats were divided into four groups: (1) control, n = 6; (2) LPS (LPS, 10 mg/kg, i.v.), n = 7; (3) LPS + indomethacin (Indo) (LPS, 10 mg/kg and indomethacin 5 mg/kg, i.v.), n = 7; and (4) Indo (indomethacin 5 mg/kg, i.v.), n = 7. Additionally, gastric microcirculation was investigated using in vivo microscopy. Tissue malondialdehyde (MDA) and glutathione levels were measured at the conclusion of the experiment. Specifically, microdialysis was used to measure the 6-keto-PGF1alpha, a stable metabolite of PGI2, while flow cytometry was used to measure the CD11b/CD18 expression of circulating neutrophils. Compared with LPS alone, LPS with Indo significantly impaired gastric microcirculation and systemic hemodynamics. LPS-induced gastroprotection was lost, as evidenced by the increased adherent leukocyte count, decreased flow velocity in the post-capillary venules, and increased tissue MDA production. Meanwhile, the luminal glucose and protein contents that comprised the gastric mucosa injury index were significantly increased. These effects of Indo are directly associated with the levels of PGI2 in gastric tissue, which increased with LPS alone and significantly decreased with a combination of LPS and Indo. This work demonstrates that PGI2 contributes to LPS-induced gastroprotection." @default.
• W2057434505 created "2016-06-24" @default.
• W2057434505 creator A5060025004 @default.
• W2057434505 creator A5064571126 @default.
• W2057434505 creator A5080094505 @default.
• W2057434505 creator A5089179940 @default.
• W2057434505 creator A5091096533 @default.
• W2057434505 date "2002-04-01" @default.
• W2057434505 modified "2023-09-23" @default.
• W2057434505 title "Role of Prostacyclin on Microcirculation in Endotoxin-Induced Gastroprotection in Rats: A Microdialysis Study" @default.
• W2057434505 cites W1574945736 @default.
• W2057434505 cites W162447880 @default.
• W2057434505 cites W1982802103 @default.
• W2057434505 cites W1993910296 @default.
• W2057434505 cites W1996074682 @default.
• W2057434505 cites W2002338458 @default.
• W2057434505 cites W2002540320 @default.
• W2057434505 cites W2020888951 @default.
• W2057434505 cites W2021855226 @default.
• W2057434505 cites W2022792869 @default.
• W2057434505 cites W2030979666 @default.
• W2057434505 cites W2036316303 @default.
• W2057434505 cites W2047930977 @default.
• W2057434505 cites W2051400136 @default.
• W2057434505 cites W2059154584 @default.
• W2057434505 cites W2070805549 @default.
• W2057434505 cites W2074158660 @default.
• W2057434505 cites W2074795563 @default.
• W2057434505 cites W2083740192 @default.
• W2057434505 cites W2086170643 @default.
• W2057434505 cites W2414475801 @default.
• W2057434505 cites W4214589643 @default.
• W2057434505 cites W2050498413 @default.
• W2057434505 doi "https://doi.org/10.1097/00024382-200204000-00017" @default.
• W2057434505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11954837" @default.
• W2057434505 hasPublicationYear "2002" @default.
• W2057434505 type Work @default.
• W2057434505 sameAs 2057434505 @default.
• W2057434505 citedByCount "6" @default.
• W2057434505 countsByYear W20574345052014 @default.
• W2057434505 countsByYear W20574345052019 @default.
• W2057434505 crossrefType "journal-article" @default.
• W2057434505 hasAuthorship W2057434505A5060025004 @default.
• W2057434505 hasAuthorship W2057434505A5064571126 @default.
• W2057434505 hasAuthorship W2057434505A5080094505 @default.
• W2057434505 hasAuthorship W2057434505A5089179940 @default.
• W2057434505 hasAuthorship W2057434505A5091096533 @default.
• W2057434505 hasBestOaLocation W20574345051 @default.
• W2057434505 hasConcept C126322002 @default.
• W2057434505 hasConcept C12722491 @default.
• W2057434505 hasConcept C134018914 @default.
• W2057434505 hasConcept C146957229 @default.
• W2057434505 hasConcept C150903083 @default.
• W2057434505 hasConcept C185592680 @default.
• W2057434505 hasConcept C207001950 @default.
• W2057434505 hasConcept C2776151105 @default.
• W2057434505 hasConcept C2778401633 @default.
• W2057434505 hasConcept C2778754761 @default.
• W2057434505 hasConcept C2779422922 @default.
• W2057434505 hasConcept C2780664492 @default.
• W2057434505 hasConcept C2781128415 @default.
• W2057434505 hasConcept C2781443798 @default.
• W2057434505 hasConcept C28406088 @default.
• W2057434505 hasConcept C2859252 @default.
• W2057434505 hasConcept C50156730 @default.
• W2057434505 hasConcept C55493867 @default.
• W2057434505 hasConcept C71924100 @default.
• W2057434505 hasConcept C86803240 @default.
• W2057434505 hasConcept C98274493 @default.
• W2057434505 hasConceptScore W2057434505C126322002 @default.
• W2057434505 hasConceptScore W2057434505C12722491 @default.
• W2057434505 hasConceptScore W2057434505C134018914 @default.
• W2057434505 hasConceptScore W2057434505C146957229 @default.
• W2057434505 hasConceptScore W2057434505C150903083 @default.
• W2057434505 hasConceptScore W2057434505C185592680 @default.
• W2057434505 hasConceptScore W2057434505C207001950 @default.
• W2057434505 hasConceptScore W2057434505C2776151105 @default.
• W2057434505 hasConceptScore W2057434505C2778401633 @default.
• W2057434505 hasConceptScore W2057434505C2778754761 @default.
• W2057434505 hasConceptScore W2057434505C2779422922 @default.
• W2057434505 hasConceptScore W2057434505C2780664492 @default.
• W2057434505 hasConceptScore W2057434505C2781128415 @default.
• W2057434505 hasConceptScore W2057434505C2781443798 @default.
• W2057434505 hasConceptScore W2057434505C28406088 @default.
• W2057434505 hasConceptScore W2057434505C2859252 @default.
• W2057434505 hasConceptScore W2057434505C50156730 @default.
• W2057434505 hasConceptScore W2057434505C55493867 @default.
• W2057434505 hasConceptScore W2057434505C71924100 @default.
• W2057434505 hasConceptScore W2057434505C86803240 @default.
• W2057434505 hasConceptScore W2057434505C98274493 @default.
• W2057434505 hasIssue "4" @default.
• W2057434505 hasLocation W20574345051 @default.
• W2057434505 hasLocation W20574345052 @default.
• W2057434505 hasLocation W20574345053 @default.
• W2057434505 hasOpenAccess W2057434505 @default.
• W2057434505 hasPrimaryLocation W20574345051 @default.
• W2057434505 hasRelatedWork W1608573208 @default.
• W2057434505 hasRelatedWork W1969640580 @default.

• next